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Review

Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway

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Pages 357-365 | Published online: 15 Nov 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Kuan-Wei Huang & Tiao-Lai Huang. (2023) Association between programmed death-1 pathway and major depression. The World Journal of Biological Psychiatry 24:9, pages 822-828.
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Zhiqiang Yang & Fan He. (2023) An immune cell infiltration landscape classification to predict prognosis and immunotherapy effect in oral squamous cell carcinoma. Computer Methods in Biomechanics and Biomedical Engineering 0:0, pages 1-13.
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Yutong He, Jin Shi, Bernd Schmidt, Qingyi Liu, Gaofeng Shi, Xiaoli Xu, Congmin Liu, Zhaoyu Gao, Tiantian Guo & Baoen Shan. (2020) Circulating Tumor Cells as a Biomarker to Assist Molecular Diagnosis for Early Stage Non-Small Cell Lung Cancer. Cancer Management and Research 12, pages 841-854.
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Omar Abdel-Rahman, Hani Oweira & Anwar Giryes. (2018) Health-related quality of life in cancer patients treated with PD-(L)1 inhibitors: a systematic review. Expert Review of Anticancer Therapy 18:12, pages 1231-1239.
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Peng-Fei Cui, Jun-Xun Ma, Fei-Xue Wang, Jing Zhang, Hai-Tao Tao & Yi Hu. (2017) Pneumonitis and pneumonitis-related death in cancer patients treated with programmed cell death-1 inhibitors: a systematic review and meta-analysis. Therapeutics and Clinical Risk Management 13, pages 1259-1271.
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Xiangyi Kong & Yanguo Kong. (2017) Evidence from a meta-analysis: is nivolumabneurotoxic in cancer patients?. OncoTargets and Therapy 10, pages 1335-1344.
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Yi Zheng, Yicheng Yang, Shu Wu, Yongqiang Zhu, Xiaolong Tang & Xiaopeng Liu. (2017) Combining MPDL3280A with adoptive cell immunotherapy exerts better antitumor effects against cervical cancer. Bioengineered 8:4, pages 367-373.
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Mostafa Eltobgy, Hani Oweira, Ulf Petrausch, Daniel Helbling, Jan Schmidt, Arianeb Mehrabi, Othmar Schöb, Anwar Giryes, Michael Decker & Omar Abdel-Rahman. (2017) Immune-related neurological toxicities among solid tumor patients treated with immune checkpoint inhibitors: a systematic review. Expert Review of Neurotherapeutics 17:7, pages 725-736.
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Jan Trøst Jørgensen. (2016) Companion diagnostic assays for PD-1/PD-L1 checkpoint inhibitors in NSCLC. Expert Review of Molecular Diagnostics 16:2, pages 131-133.
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Thanashan Rajakulendran & David N Adam. (2015) Spotlight on pembrolizumab in the treatment of advanced melanoma. Drug Design, Development and Therapy 9, pages 2883-2886.
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Tania Crombet Ramos, Pedro Camilo Rodríguez, Elia Neninger Vinageras, Beatriz Garcia Verdecia & Agustin Lage Davila. (2015) CIMAvax EGF (EGF-P64K) vaccine for the treatment of non-small-cell lung cancer. Expert Review of Vaccines 14:10, pages 1303-1311.
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Omar Abdel-Rahman, Hesham ElHalawani & Mona Fouad. (2015) Risk of elevated transaminases in cancer patients treated with immune checkpoint inhibitors: a meta-analysis. Expert Opinion on Drug Safety 14:10, pages 1507-1518.
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Peter Norman. (2015) Orphan drug approvals of 2014: Europe and the United States. Expert Opinion on Orphan Drugs 3:4, pages 445-455.
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Articles from other publishers (11)

Xin Guo, Yuelin Zhang, Hengxing Jiao & Xingyu Miao. (2022) The prognostic significance of PD-L1 expression in patients with glioblastoma: A meta-analysis. Frontiers in Oncology 12.
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Giandomenico Roviello, Martina Catalano, Raffaella Santi, Valeria Emma Palmieri, Gianmarco Vannini, Ilaria Camilla Galli, Eleonora Buttitta, Donata Villari, Virginia Rossi & Gabriella Nesi. (2021) Immune Checkpoint Inhibitors in Urothelial Bladder Cancer: State of the Art and Future Perspectives. Cancers 13:17, pages 4411.
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Yujia Zhai, Reza Moosavi & Mingnan Chen. (2021) Immune Checkpoints, a Novel Class of Therapeutic Targets for Autoimmune Diseases. Frontiers in Immunology 12.
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Chengyi Mao, Xiaoxi Zeng, Chao Zhang, Yushang Yang, Xin Xiao, Siyuan Luan, Yonggang Zhang & Yong Yuan. (2021) Mechanisms of Pharmaceutical Therapy and Drug Resistance in Esophageal Cancer. Frontiers in Cell and Developmental Biology 9.
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Tsvetelina Velikova, Boris Krastev, Stefan Lozenov, Radostina Gencheva, Monika Peshevska-Sekulovska, Georgi Nikolaev & Milena Peruhova. (2021) Antibiotic-Related Changes in Microbiome: The Hidden Villain behind Colorectal Carcinoma Immunotherapy Failure. International Journal of Molecular Sciences 22:4, pages 1754.
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Vincent Wuidar, Lionel Gillot, Isabelle Dias Da Silva, Alizée Lebeau, Anne Gallez & Christel Pequeux. 2021. Tumor Microenvironment. Tumor Microenvironment 499 533 .
Nayson L Fernandes, Soujanya Sodavarapu, Sukhmine Nedopil, Nikita Mohapatra & Dinesh Vyas. (2020) Checkpoint Inhibitor in a Melanoma Patient With Polyendocrinopathy and Gangrenous Gall Bladder With a Mass. Cureus.
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Florian Guisier, Mateus Camargo Barros-Filho, Leigha D. Rock, Megan Strachan-Whaley, Erin A. Marshall, Graham Dellaire & Wan L. Lam. 2020. Tumor Microenvironment. Tumor Microenvironment 35 51 .
Yinan Dong, Qian Sun & Xinwei Zhang. (2016) PD-1 and its ligands are important immune checkpoints in cancer. Oncotarget 8:2, pages 2171-2186.
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Qing Li, Nathan Johnston, Xiufen Zheng, Hongmei Wang, Xusheng Zhang, Dian Gao & Weiping Min. (2016) miR-28 modulates exhaustive differentiation of T cells through silencing programmed cell death-1 and regulating cytokine secretion. Oncotarget 7:33, pages 53735-53750.
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Jing Zeng, Xin-Ke Zhang, Hua-Dong Chen, Zhi-Hai Zhong, Qiu-Liang Wu & Su-Xia Lin. (2016) Expression of programmed cell death-ligand 1 and its correlation with clinical outcomes in gliomas. Oncotarget 7:8, pages 8944-8955.
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