Pharmacogenomics and Personalized Medicine, Volume 7, Issue (2014)

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Pharmacogenomics and Personalized Medicine, Volume 7, Issue (2014)

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Review

Review Article
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients
Anna Tessari, Dario Palmieri & Serena Di Cosimo
Pages: 1-19
Published online: 22 Dec 2022
AbstractforOverview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients | Full Text | References | PDF (658.7 KB)
  • 123 Views
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Review Article
Dabrafenib for treatment of BRAF-mutant melanoma
Radhika Kainthla, Kevin B Kim & Gerald S Falchook
Pages: 21-29
Published online: 22 Dec 2022
AbstractforDabrafenib for treatment of BRAF-mutant melanoma | Full Text | References | PDF (316.8 KB)
  • 105 Views
  • 3 CrossRef citations
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Review Article
Targeted treatment of folate receptor-positive platinum-resistant ovarian cancer and companion diagnostics, with specific focus on vintafolide and etarfolatide
Loredana Serpe, Margherita Gallicchio, Roberto Canaparo & Franco Dosio
Pages: 31-42
Published online: 22 Dec 2022
AbstractforTargeted treatment of folate receptor-positive platinum-resistant ovarian cancer and companion diagnostics, with specific focus on vintafolide and etarfolatide | Full Text | References | PDF (553 KB)
  • 87 Views
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Review Article
Molecular variants and mutations in medulloblastoma
Kristin Schroeder & Sri Gururangan
Pages: 43-51
Published online: 22 Dec 2022
AbstractforMolecular variants and mutations in medulloblastoma | Full Text | References | PDF (245.3 KB)
  • 133 Views
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Review Article
Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics
Kohji Noguchi, Kazuhiro Katayama & Yoshikazu Sugimoto
Pages: 53-64
Published online: 05 Feb 2014
AbstractforHuman ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics | Full Text | References | PDF (811.3 KB)
  • 183 Views
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Open Access
Review Article
Glioblastoma extracellular vesicles: reservoirs of potential biomarkers
Jasmina S Redzic, Timothy H Ung & Michael W Graner
Pages: 65-77
Published online: 22 Dec 2022
AbstractforGlioblastoma extracellular vesicles: reservoirs of potential biomarkers | Full Text | References | PDF (1.2 MB)
  • 164 Views
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Review Article
Role of brentuximab vedotin in the treatment of relapsed or refractory Hodgkin lymphoma
Tanya Siddiqi, Sandra H Thomas & Robert Chen
Pages: 79-85
Published online: 20 Feb 2014
AbstractforRole of brentuximab vedotin in the treatment of relapsed or refractory Hodgkin lymphoma | Full Text | References | PDF (413.8 KB)
  • 101 Views
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Open Access
Review Article
ALK-driven tumors and targeted therapy: focus on crizotinib
Carlos Murga-Zamalloa & Megan S Lim
Pages: 87-94
Published online: 20 Mar 2014
AbstractforALK-driven tumors and targeted therapy: focus on crizotinib | Full Text | References | PDF (208.7 KB)
  • 82 Views
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Open Access
Review Article
Precision medicine and personalized breast cancer: combination pertuzumab therapy
Kerry Reynolds, Sasmit Sarangi, Aditya Bardia & Don S Dizon
Pages: 95-105
Published online: 20 Mar 2014
AbstractforPrecision medicine and personalized breast cancer: combination pertuzumab therapy | Full Text | References | PDF (774.3 KB)
  • 142 Views
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Review Article
Targeted treatments in advanced renal cell carcinoma: focus on axitinib
Elena Verzoni, Paolo Grassi, Isabella Testa, Roberto Iacovelli, Pamela Biondani, Enrico Garanzini, Filippo De Braud & Giuseppe Procopio
Pages: 107-116
Published online: 27 Mar 2014
AbstractforTargeted treatments in advanced renal cell carcinoma: focus on axitinib | Full Text | References | PDF (552.5 KB)
  • 55 Views
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Original Research

Article
Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients
Antonietta Caruso, Chiara Bellia, Alessia Pivetti, Luisa Agnello, Federica Bazza, Concetta Scazzone, Giulia Bivona, Bruna Lo Sasso & Marcello Ciaccio
Pages: 117-120
Published online: 02 Apr 2014
AbstractforEffects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients | Full Text | References | PDF (167.8 KB)
  • 87 Views
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Rapid Communication

Article
Possible impact of the CYP2D6*10 polymorphism on the nonlinear pharmacokinetic parameter estimates of paroxetine in Japanese patients with major depressive disorders
Junji Saruwatari, Hiroo Nakashima, Shoko Tsuchimine, Miki Nishimura, Naoki Ogusu & Norio Yasui-Furukori
Pages: 121-127
Published online: 28 Apr 2014
AbstractforPossible impact of the CYP2D6*10 polymorphism on the nonlinear pharmacokinetic parameter estimates of paroxetine in Japanese patients with major depressive disorders | Full Text | References | PDF (627.3 KB)
  • 75 Views
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Review

Review Article
Personalized therapy algorithms for type 2 diabetes: a phenotype-based approach
Antonio Ceriello, Marco Gallo, Riccardo Candido, Alberto De Micheli, Katherine Esposito, Sandro Gentile & Gerardo Medea
Pages: 129-136
Published online: 22 Dec 2022
AbstractforPersonalized therapy algorithms for type 2 diabetes: a phenotype-based approach | Full Text | References | PDF (1.1 MB)
  • 167 Views
  • 7 CrossRef citations
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Open Access
Review Article
Targeting metastatic colorectal cancer – present and emerging treatment options
Kristen K Ciombor & Jordan Berlin
Pages: 137-144
Published online: 22 Dec 2022
AbstractforTargeting metastatic colorectal cancer – present and emerging treatment options | Full Text | References | PDF (251.8 KB)
  • 72 Views
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Original Research

Article
Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties
Katherine A Johansen Taber & Barry D Dickinson
Pages: 145-162
Published online: 22 Dec 2022
AbstractforPharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties | Full Text | References | PDF (586 KB)
  • 211 Views
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Open Access
Article
CYP19A1 single nucleotide polymorphism associations with CYP19A1, NFκB1, and IL6 gene expression in human normal colon and normal liver samples
Rosalind B Penney, Abbie Lundgreen, Aiwei Yao-Borengasser, Vineetha K Edavana, Suzanne Williams, Ishwori Dhakal, Roger K Wolff, Susan Kadlubar & Martha L Slattery
Pages: 163-171
Published online: 14 Jul 2014
AbstractforCYP19A1 single nucleotide polymorphism associations with CYP19A1, NFκB1, and IL6 gene expression in human normal colon and normal liver samples | Full Text | References | PDF (289.1 KB)
  • 59 Views
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Review

Review Article
MicroRNA binding site polymorphisms as biomarkers in cancer management and research
Monica Cipollini & Federica Gemignani
Pages: 173-191
Published online: 23 Jul 2014
AbstractforMicroRNA binding site polymorphisms as biomarkers in cancer management and research | Full Text | References | PDF (468.4 KB)
  • 96 Views
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Review Article
Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer
Brennan Decker & Elaine A Ostrander
Pages: 193-201
Published online: 22 Dec 2022
AbstractforDysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer | Full Text | References | PDF (428.9 KB)
  • 113 Views
  • 3 CrossRef citations
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Open Access
Review Article
Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways
Sarah R Hosford & Todd W Miller
Pages: 203-215
Published online: 22 Dec 2022
AbstractforClinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways | Full Text | References | PDF (8.3 MB)
  • 318 Views
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Open Access

Expert Opinion

Editorial
Analytical strategies for discovery and replication of genetic effects in pharmacogenomic studies
Jared R Kohler, Tobias Guennel & Scott L Marshall
Pages: 217-225
Published online: 22 Dec 2022
AbstractforAnalytical strategies for discovery and replication of genetic effects in pharmacogenomic studies | Full Text | References | PDF (1.1 MB)
  • 47 Views
  • 1 CrossRef citations
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Review

Review Article
Implementation and utilization of genetic testing in personalized medicine
Noura S Abul-Husn, Aniwaa Owusu Obeng, Saskia C Sanderson, Omri Gottesman & Stuart A Scott
Pages: 227-240
Published online: 22 Dec 2022
AbstractforImplementation and utilization of genetic testing in personalized medicine | Full Text | References | PDF (314.7 KB)
  • 718 Views
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Open Access
Review Article
Simeprevir for the treatment of hepatitis C virus infection
Laure Izquierdo, François Helle, Catherine François, Sandrine Castelain, Gilles Duverlie & Etienne Brochot
Pages: 241-249
Published online: 22 Dec 2022
AbstractforSimeprevir for the treatment of hepatitis C virus infection | Full Text | References | PDF (290.4 KB)
  • 140 Views
  • 14 CrossRef citations
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Open Access
Review Article
Developments in renal pharmacogenomics and applications in chronic kidney disease
Ariadna Padullés, Inés Rama, Inés Llaudó & Núria Lloberas
Pages: 251-266
Published online: 22 Dec 2022
AbstractforDevelopments in renal pharmacogenomics and applications in chronic kidney disease | Full Text | References | PDF (377.2 KB)
  • 163 Views
  • 1 CrossRef citations
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Open Access
Review Article
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling
Grazia Daniela Femminella, Vincenzo Barrese, Nicola Ferrara & Giuseppe Rengo
Pages: 267-273
Published online: 22 Dec 2022
AbstractforTailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling | Full Text | References | PDF (225.6 KB)
  • 47 Views
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Open Access
Review Article
Developing genomic knowledge bases and databases to support clinical management: current perspectives
Vojtech Huser, Murat Sincan & James J Cimino
Pages: 275-283
Published online: 22 Dec 2022
AbstractforDeveloping genomic knowledge bases and databases to support clinical management: current perspectives | Full Text | References | PDF (626.1 KB)
  • 90 Views
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Review Article
Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer
Timothy A Yap & Sanjay Popat
Pages: 285-295
Published online: 22 Dec 2022
AbstractforToward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer | Full Text | References | PDF (581.4 KB)
  • 89 Views
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Original Research

Article
Pharmacogenetic information for patients on drug labels
Susanne B Haga, Rachel Mills & Jivan Moaddeb
Pages: 297-305
Published online: 22 Dec 2022
AbstractforPharmacogenetic information for patients on drug labels | Full Text | References | PDF (302.7 KB)
  • 69 Views
  • 1 CrossRef citations
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Review

Review Article
Novel treatment strategies in triple-negative breast cancer: specific role of poly(adenosine diphosphate-ribose) polymerase inhibition
M William Audeh
Pages: 307-316
Published online: 22 Dec 2022
AbstractforNovel treatment strategies in triple-negative breast cancer: specific role of poly(adenosine diphosphate-ribose) polymerase inhibition | Full Text | References | PDF (264.5 KB)
  • 61 Views
  • 13 CrossRef citations
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Open Access
Review Article
Clinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders
Florence CF Chang & Victor SC Fung
Pages: 317-328
Published online: 22 Dec 2022
AbstractforClinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders | Full Text | References | PDF (290.7 KB)
  • 71 Views
  • 2 CrossRef citations
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Open Access
Review Article
Profiling and targeting HER2-positive breast cancer using trastuzumab emtansine
Saeed Sadeghi, Olga Olevsky & Sara A Hurvitz
Pages: 329-338
Published online: 22 Dec 2022
AbstractforProfiling and targeting HER2-positive breast cancer using trastuzumab emtansine | Full Text | References | PDF (925.9 KB)
  • 189 Views
  • 8 CrossRef citations
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Open Access
Review Article
Clinical utility of pharmacogenomics in the management of hepatitis C
Julieta Trinks, María Laura Hulaniuk, María Ana Redal & Diego Flichman
Pages: 339-347
Published online: 22 Dec 2022
AbstractforClinical utility of pharmacogenomics in the management of hepatitis C | Full Text | References | PDF (1.5 MB)
  • 51 Views
  • 1 CrossRef citations
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Open Access
Review Article
Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder
Florence Levy
Pages: 349-356
Published online: 22 Dec 2022
AbstractforApplications of pharmacogenetics in children with attention-deficit/hyperactivity disorder | Full Text | References | PDF (247.6 KB)
  • 75 Views
  • 3 CrossRef citations
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Open Access
Review Article
Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway
Parisa Momtaz & Michael A Postow
Pages: 357-365
Published online: 22 Dec 2022
AbstractforImmunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway | Full Text | References | PDF (630 KB)
  • 162 Views
  • 24 CrossRef citations
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Open Access
Review Article
Patient profiling in diabetes and role of canagliflozin
Ambika Amblee
Pages: 367-377
Published online: 22 Dec 2022
AbstractforPatient profiling in diabetes and role of canagliflozin | Full Text | References | PDF (287.8 KB)
  • 72 Views
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Original Research

Article
Mycophenolic acid AUC in Thai kidney transplant recipients receiving low dose mycophenolate and its association with UGT2B7 polymorphisms
Manop Pithukpakorn, Tiwat Tiwawanwong, Yupaporn Lalerd, Anunchai Assawamakin, Nalinee Premasathian, Adis Tasanarong, Wanna Thongnoppakhun & Attapong Vongwiwatana
Pages: 379-385
Published online: 22 Dec 2022
AbstractforMycophenolic acid AUC in Thai kidney transplant recipients receiving low dose mycophenolate and its association with UGT2B7 polymorphisms | Full Text | References | PDF (481.3 KB)
  • 69 Views
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Review

Review Article
Finally sofosbuvir: an oral anti-HCV drug with wide performance capability
Zeid Kayali & Warren N Schmidt
Pages: 387-398
Published online: 22 Dec 2022
AbstractforFinally sofosbuvir: an oral anti-HCV drug with wide performance capability | Full Text | References | PDF (773 KB)
  • 133 Views
  • 10 CrossRef citations
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Review Article
Diabetic retinopathy: variations in patient therapeutic outcomes and pharmacogenomics
Aniruddha Agarwal, Mohamed K Soliman, Yasir J Sepah, Diana V Do & Quan Dong Nguyen
Pages: 399-409
Published online: 22 Dec 2022
AbstractforDiabetic retinopathy: variations in patient therapeutic outcomes and pharmacogenomics | Full Text | References | PDF (741.9 KB)
  • 99 Views
  • 6 CrossRef citations
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