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Review

Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson’s disease

Pages 57-64 | Published online: 20 Jan 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Ahmed Elkamhawy, Sora Paik, Hyeon Jeong Kim, Jong-Hyun Park, Ashwini M. Londhe, Kyeong Lee, Ae Nim Pae, Ki Duk Park & Eun Joo Roh. (2020) Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1568-1580.
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Wonsuk Shin, Kyoung Soo Lim, Min-Kyoung Kim, Hyun Sook Kim, Jihwa Hong, Stanford Jhee, Joseph Kim, Sungeun Yoo, Yeon-Tae Chung, Jae Moon Lee & Doo-Yeoun Cho. (2019) A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy volunteers. Drug Design, Development and Therapy 13, pages 1011-1022.
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Bin Liu, Chaonan Lv, Jinxia Zhang, Ying Liu, Jing Sun, Xiaohua Cheng, Wenjing Mao, Yuanyuan Ma & Shiying Li. (2017) Effects of eldepryl on glial cell proliferation and activation in the substantia nigra and striatum in a rat model of Parkinson’s disease. Neurological Research 39:5, pages 459-467.
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Articles from other publishers (17)

Ashraf K. El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim & Gyochang Keum. (2023) Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors. Pharmaceuticals 16:1, pages 83.
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Ahmed Elkamhawy, Hyeon Jeong Kim, Mohamed H. Elsherbeny, Sora Paik, Jong-Hyun Park, Lizaveta Gotina, Magda H. Abdellattif, Noha A. Gouda, Jungsook Cho, Kyeong Lee, Ae Nim Pae, Ki Duk Park & Eun Joo Roh. (2021) Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action. Bioorganic Chemistry 116, pages 105352.
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Min-Ho Nam, Jong-Hyun Park, Hyo Jung Song, Ji Won Choi, Siwon Kim, Bo Ko Jang, Hyung Ho Yoon, Jun Young Heo, Hyowon Lee, Heeyoung An, Hyeon Jeong Kim, Sun Jun Park, Doo-Wan Cho, Young-Su Yang, Su-Cheol Han, Sangwook Kim, Soo-Jin Oh, Sang Ryong Jeon, Ki Duk Park & C. Justin Lee. (2021) KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson’s Disease. Neurotherapeutics 18:3, pages 1729-1747.
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Sri Jayanti, Rita Moretti, Claudio Tiribelli & Silvia Gazzin. (2021) Bilirubin: A Promising Therapy for Parkinson’s Disease. International Journal of Molecular Sciences 22:12, pages 6223.
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Marco Gallazzi, Marco Mauri, Maria Laura Bianchi, Giulio Riboldazzi, Lucia Princiotta Cariddi, Federico Carimati, Valentina Rebecchi & Maurizio Versino. (2021) Selegiline reduces daytime sleepiness in patients with Parkinson's disease. Brain and Behavior 11:5.
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Ariana Q. Farrand, Ryan S. Verner, Ryan M. McGuire, Kristi L. Helke, Vanessa K. Hinson & Heather A. Boger. (2020) Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s disease. Brain Stimulation 13:5, pages 1323-1332.
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Min-Ho Nam, Moosung Park, Hyeri Park, Youngjae Kim, Seulki Yoon, Vikram Shahaji Sawant, Ji Won Choi, Jong-Hyun Park, Ki Duk Park, Sun-Joon Min, C. Justin Lee & Hyunah Choo. (2017) Indole-Substituted Benzothiazoles and Benzoxazoles as Selective and Reversible MAO-B Inhibitors for Treatment of Parkinson’s Disease. ACS Chemical Neuroscience 8:7, pages 1519-1529.
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Zhaofei Yang, Xuan Wang, Jian Yang, Min Sun, Yong Wang & Xiaomin Wang. (2016) Aberrant CpG Methylation Mediates Abnormal Transcription of MAO-A Induced by Acute and Chronic l-3,4-Dihydroxyphenylalanine Administration in SH-SY5Y Neuronal Cells. Neurotoxicity Research 31:3, pages 334-347.
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Dan-dan Yang, Riu Wang, Jin-long Zhu, Qi-yue Cao, Jie Qin, Hai-liang Zhu & Shao-song Qian. (2017) Synthesis, crystal structures, molecular docking, in vitro monoamine oxidase-B inhibitory activity of transition metal complexes with 2-{4-[bis (4-fluorophenyl)methyl]piperazin-1-yl} acetic acid. Journal of Molecular Structure 1128, pages 493-498.
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Alexey Moskalev, Elizaveta Chernyagina, Vasily Tsvetkov, Alexander Fedintsev, Mikhail Shaposhnikov, Vyacheslav Krut'ko, Alex Zhavoronkov & Brian K. Kennedy. (2016) Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging Cell 15:3, pages 407-415.
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Bin Liu, Jing Sun, Jinxia Zhang, Wenjing Mao, Yuanyuan Ma, Shiying Li, Xiaohua Cheng & Chaonan Lv. (2015) Autophagy-related protein expression in the substantia nigra and eldepryl intervention in rat models of Parkinson׳s disease. Brain Research 1625, pages 180-188.
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Daphne Robakis & Stanley Fahn. (2015) Defining the Role of the Monoamine Oxidase-B Inhibitors for Parkinson’s Disease. CNS Drugs 29:6, pages 433-441.
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Yong-Xin Sun, Xiao-Hong Wang, Ai-Hua Xu & Jiu-Han Zhao. (2014) Functional polymorphisms of the MAO gene with Parkinson disease susceptibility: A meta-analysis. Journal of the Neurological Sciences 345:1-2, pages 97-105.
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Ildikó Miklya. (2014) Essential difference between the pharmacological spectrum of (−)-deprenyl and rasagiline. Pharmacological Reports 66:3, pages 453-458.
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Anupom Borah, Rajib Paul, Sabanum Choudhury, Amarendranath Choudhury, Bornalee Bhuyan, Anupam Das Talukdar, Manabendra Dutta Choudhury & Kochupurackal P Mohanakumar. (2013) Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action. CNS Neuroscience & Therapeutics 19:11, pages 847-853.
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Lina Zhang, Zhiqin Zhang, Yangmei Chen, Xinyue Qin, Huadong Zhou, Chaodong Zhang, Hongbin Sun, Ronghua Tang, Jinou Zheng, Lin Yi, Liying Deng & Jinfang Li. (2013) Efficacy and safety of rasagiline as an adjunct to levodopa treatment in Chinese patients with Parkinson's disease: a randomized, double-blind, parallel-controlled, multi-centre trial. International Journal of Neuropsychopharmacology 16:7, pages 1529-1537.
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Bradley J. Robottom, Lisa M. Shulman & William J. Weiner. (2012) Drug-Induced Movement Disorders: Emergencies and Management. Neurologic Clinics 30:1, pages 309-320.
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