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Review

Uterine fibroids: an update on current and emerging medical treatment options

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Pages 157-178 | Published online: 23 Jan 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Jakub Kociuba, Tomasz Łoziński, Magdalena Zgliczyńska, Maciej Byrczak, Salvatore Giovanni Vitale, Maciej Skrzypczak, Kornelia Zaręba & Michał Ciebiera. (2023) Adverse events and complications after magnetic resonance-guided focused ultrasound (MRgFUS) therapy in uterine fibroids – a systematic review and future perspectives. International Journal of Hyperthermia 40:1.
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Michał Ciebiera, Obianuju Sandra Madueke-Laveaux, Stepan Feduniw, Mara Ulin, Robert Spaczyński, Magdalena Zgliczyńska, Monika Bączkowska, Elżbieta Zarychta, Tomasz Łoziński, Mohamed Ali & Ayman Al-Hendy. (2023) GnRH agonists and antagonists in therapy of symptomatic uterine fibroids – current roles and future perspectives. Expert Opinion on Pharmacotherapy 24:16, pages 1799-1809.
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Alison Downham Moore, Fouzieyha Towghi, Holly Rose Ashford, Tinashe Dune & Rashmi Pithavadian. (2023) The global proliferation of radical gynaecological surgeries: A history of the present. History and Anthropology 34:4, pages 673-697.
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Mohamed Ali, Mohamed Raslan, Michał Ciebiera, Kornelia Zaręba & Ayman Al-Hendy. (2022) Current approaches to overcome the side effects of GnRH analogs in the treatment of patients with uterine fibroids. Expert Opinion on Drug Safety 21:4, pages 477-486.
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Mohamed Ali, Hsin-Yuan Chen, Yi-Fen Chiang, Osama A Badary, Shih-Min Hsia & Ayman Al-Hendy. (2022) An evaluation of relugolix/estradiol/norethindrone acetate for the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women. Expert Opinion on Pharmacotherapy 23:4, pages 421-429.
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Mohamed Ali, Sara A.R.Ayman Al Hendy. (2021) Elagolix in the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women. Expert Review of Clinical Pharmacology 14:4, pages 427-437.
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Fabio Barra, Salvatore Giovanni Vitale, Marta Seca, Carolina Scala, Umberto Leone Roberti Maggiore, Antonio Cianci & Simone Ferrero. (2020) The potential role of elagolix for treating uterine bleeding associated to uterine myomas. Expert Opinion on Pharmacotherapy 21:12, pages 1419-1430.
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Articles from other publishers (28)

A Di Spiezio Sardo, F Ciccarone, L Muzii, G Scambia & M Vignali. (2023) Use of oral GnRH antagonists combined therapy in the management of symptomatic uterine fibroids. Facts, Views and Vision in ObGyn 15:1, pages 29-33.
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Alison M Downham Moore. (2023) Race, class, caste, disability, sterilisation and hysterectomy. Medical Humanities 49:1, pages 27-37.
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Giuseppe Benagiano. (2023) Research as mission: Ivo Brosens, in memoriam. Journal of Endometriosis and Uterine Disorders 1, pages 100015.
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Minnie Malik, Joy L. Britten, Anthony DeAngelis, Collin Sitler, Sean Moran, Jaime A. Roura-Monllor, Paul Driggers & William H. Catherino. (2023) Curcumin inhibits human leiomyoma xenograft tumor growth and induces dissolution of the extracellular matrix. F&S Science 4:1, pages 74-89.
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Narvella Sefah, Sithembinkosi Ndebele, Lillian Prince, Elizabeth Korasare, Michael Agbleke, Annabella Nkansah, Humphrey Thompson, Ayman Al-Hendy & Andrews Akwasi Agbleke. (2023) Uterine fibroids — Causes, impact, treatment, and lens to the African perspective. Frontiers in Pharmacology 13.
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J. Estadella Tarriel, J. Perelló Capó & R. Muñoz Sánchez. (2023) Actualización sobre las posibilidades de tratamiento médico hormonal para el sangrado menstrual abundante. Clínica e Investigación en Ginecología y Obstetricia 50:1, pages 100819.
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Iason Psilopatis, Florian Nima Fleckenstein, Federico Collettini, Elif Can, Anne Frisch, Bernhard Gebauer, Uli Fehrenbach, Giovanni Federico Torsello, Dirk Schnapauff, Matthias David & Gero Wieners. (2022) Short- and long-term evaluation of disease-specific symptoms and quality of life following uterine artery embolization of fibroids. Insights into Imaging 13:1.
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Rabiya Niaz, Memoona Saeed, Huda Khan, Muhammad Ashar Ali, Ahmed Irshad, Marium Faiz, Alaa Irshad, Faraeha Fatima, Sameer Altaf Tunio & Wajeeha Aiman. (2022) Efficacy and Safety of Oral GnRh Antagonists in Patients With Uterine Fibroids: A Systematic Review. Journal of Obstetrics and Gynaecology Canada 44:12, pages 1279-1288.
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Akihiro Takeda. (2022) Short‐term administration of oral relugolix before single‐port laparoscopic‐assisted vaginal hysterectomy for symptomatic uterine myomas: A retrospective comparative study with leuprorelin injection. Journal of Obstetrics and Gynaecology Research 48:7, pages 1921-1929.
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Nicholas Leyland, Mathew Leonardi, Ally Murji, Sukhbir S. Singh, Ayman Al-Hendy & Linda Bradley. (2022) A Call-to-Action for Clinicians to Implement Evidence-Based Best Practices When Caring for Women with Uterine Fibroids. Reproductive Sciences 29:4, pages 1188-1196.
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Patricia Geraghty. 2022. Each Woman’s Menopause: An Evidence Based Resource. Each Woman’s Menopause: An Evidence Based Resource 147 168 .
Mekan R. Orazov, Viktor E. Radzinsky & Lemin M. Leffad. (2021) Possibilities of drug therapy for uterine leiomyoma in reproductive age. Gynecology 23:6, pages 586-591.
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Mustafa Ali, Aruna Kumari Hira, Haris Jawaid, Faiza Zakaria & Zehra Somjee. (2021) Safety and efficacy of elagolix (with and without add-back therapy) for the treatment of heavy menstrual bleeding associated with uterine leiomyomas: a systematic review and meta-analysis. Middle East Fertility Society Journal 26:1.
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Yan Luo, Wenxia Huang, Kewei Zeng, Chunfeng Zhang, Chunyan Yu & Wencui Wu. (2021) Intelligent Noise Reduction Algorithm to Evaluate the Correlation between Human Fat Deposits and Uterine Fibroids under Ultrasound Imaging. Journal of Healthcare Engineering 2021, pages 1-14.
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Tânia Ascensão, Helena Barros Leite, Sidónio Matias & Fernanda Águas. (2021) Arterial hypertension as an inaugural sign of myomatous uterus. BMJ Case Reports 14:7, pages e243270.
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Donna D. Baird & Quaker E. Harmon. (2021) Relugolix — new treatment for uterine fibroid-related heavy bleeding. Nature Reviews Endocrinology 17:6, pages 321-322.
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Li‐Min Sun, Mei‐Chun Chou, Cheng‐Li Lin & Chia‐Hung Kao. (2021) Uterine myoma is associated with an increased risk of lung cancer: A nationwide population‐based cohort study. International Journal of Clinical Practice 75:5.
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Aiqin Hou, Zhen Yan, Yuanyuan Zhang & Jing Hou. (2021) Oral Administration of Mifepristone Combined with Ultrasound-Guided Radiofrequency Ablation in Treating Patients with Uterine Fibroids: Efficacy, Safety, and Alternations of Inflammatory Cytokines, Adhesion Molecules, and Growth Factors. Journal of Nanomaterials 2021, pages 1-7.
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Z. V. Revazova, L. V. Adamyan, O. N. Loginova, L. M. Manukyan & K. N. Arslanyan. (2021) Current trends in the pharmacotherapy of uterine myoma, associated with heavy menstrual bleeding and anemia: a literature review. Obstetrics, Gynecology and Reproduction 15:1, pages 80-92.
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Emmanuel Ekanem & Vikram Talaulikar. (2020) Medical Therapy for Fibroids: What Next for Ulipristal Acetate?. Advances in Therapy 38:1, pages 137-148.
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Jihong Shon, Peng Zou, Doanh Tran, Shirley K. Seo & Yanhui Lu. (2020) Clinical Pharmacology at the Intersection of Women's Health and Regulation: Drug Development Considerations for Uterine Fibroids. The Journal of Clinical Pharmacology 60:S2.
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Hadas Bar-Joseph, Elad Hikri, Dana Chuderland, Ido Ben-Ami & Ruth Shalgi. (2020) Pigment epithelium derived factor as a novel multi-target treatment for uterine fibroids. Reproductive BioMedicine Online 41:2, pages 335-342.
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Annie P. Tran, Jennifer Al Naber, Ellen S. Tambor & Evan R. Myers. (2020) Addressing heterogenous outcomes in uterine fibroid research: a call to action. American Journal of Obstetrics and Gynecology 223:1, pages 75.e1-75.e5.
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E. N. Kareva & Т. Е. Samoylova. (2020) Uterine myoma: new and perspective options for medicinal treatment. Meditsinskiy sovet = Medical Council:3, pages 49-58.
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Meeta Gupta, Narita Jamwal, Sumeet Sabharwal & Shalini Sobti. (2020) A prospective interventional study to evaluate the effects of medical therapy (Mifepristone 25 mg) on the management of uterine fibroids. Journal of Family Medicine and Primary Care 9:7, pages 3230.
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逸龙 高. (2020) Progress in the Treatment of Hysteromyoma. Advances in Clinical Medicine 10:03, pages 260-264.
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Hareesh B. Nair, Bindu Santhamma, Kalarickal V. Dileep, Peter Binkley, Kirk Acosta, Kam Y. J. Zhang, Robert Schenken & Klaus Nickisch. (2019) EC313-a tissue selective SPRM reduces the growth and proliferation of uterine fibroids in a human uterine fibroid tissue xenograft model. Scientific Reports 9:1.
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Essam El Mahdi. (2019) Fibroids and Infertility. EMJ Reproductive Health, pages 94-99.
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