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Expert Opinion

Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics

Pages 303-333 | Published online: 25 Nov 2022

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Hazera Khatun Koly, Kakan Sutradhar & Md Sajjadur Rahman. (2023) Acetylcholinesterase inhibition of Alzheimer’s disease: identification of potential phytochemicals and designing more effective derivatives to manage disease condition. Journal of Biomolecular Structure and Dynamics 41:22, pages 12532-12544.
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Marion Ortner, Marion Stange, Heike Schneider, Charlotte Schröder, Katharina Buerger, Claudia Müller, Felix Müller-Sarnowski, Janine Diehl-Schmid, Hans Förstl, Timo Grimmer & Werner Steimer. (2020) Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil. Drug Design, Development and Therapy 14, pages 3251-3262.
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James Michael Brimson, Sirikalaya Brimson, Chanichon Chomchoei & Tewin Tencomnao. (2020) Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain. Expert Opinion on Therapeutic Targets 24:10, pages 1009-1028.
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Chih-Hsiang Fang, Yi-Wen Lin, Chun-Chen Yang, Minal Thacker, Subhaini Jakfer & Feng-Huei Lin. (2020) Characterization and evaluation of porous hydroxyapatite synthesized by oil-in-water method as carrier of donepezil for the preventive of Alzheimer’s disease by controlled release. Journal of Asian Ceramic Societies 8:4, pages 1216-1227.
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Ramón Cacabelos. (2020) Pharmacogenetic considerations when prescribing cholinesterase inhibitors for the treatment of Alzheimer’s disease. Expert Opinion on Drug Metabolism & Toxicology 16:8, pages 673-701.
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Ramon Cacabelos. (2020) Pharmacogenomics of drugs used to treat brain disorders. Expert Review of Precision Medicine and Drug Development 5:3, pages 181-234.
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Anurag Kumar Singh, Sunil Kumar Mishra, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Mukesh Kumar Yadav, Neelam Atri, Pawan Kumar Pandey & Santosh Kumar Singh. (2020) Inorganic clay nanocomposite system for improved cholinesterase inhibition and brain pharmacokinetics of donepezil. Drug Development and Industrial Pharmacy 46:1, pages 8-19.
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Thitipon Yaowaluk, Vorapun Senanarong, Chanin Limwongse, Rasda Boonprasert & Pornpimol Kijsanayotin. (2019) Influence of CYP2D6, CYP3A5, ABCB1, APOE polymorphisms and nongenetic factors on donepezil treatment in patients with Alzheimer’s disease and vascular dementia. Pharmacogenomics and Personalized Medicine 12, pages 209-224.
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Ramón Cacabelos, Natalia Cacabelos & Juan C. Carril. (2019) The role of pharmacogenomics in adverse drug reactions. Expert Review of Clinical Pharmacology 12:5, pages 407-442.
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Alexandre A. de Castro, Flávia V. Soares, Ander F. Pereira, Daniel A. Polisel, Melissa S. Caetano, Daniel H. S. Leal, Elaine F. F. da Cunha, Eugenie Nepovimova, Kamil Kuca & Teodorico C. Ramalho. (2019) Non-conventional compounds with potential therapeutic effects against Alzheimer’s disease. Expert Review of Neurotherapeutics 19:5, pages 375-395.
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Andrew Octavian Sasmita. (2019) Current viral-mediated gene transfer research for treatment of Alzheimer’s disease. Biotechnology and Genetic Engineering Reviews 35:1, pages 26-45.
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Eva Horáková, Pavel Drabina, Břetislav Brož, Šárka Štěpánková, Katarína Vorčáková, Karel Královec, Radim Havelek & Miloš Sedlák. (2016) Synthesis, characterization and in vitro evaluation of substituted N-(2-phenylcyclopropyl)carbamates as acetyl- and butyrylcholinesterase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 173-179.
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Ramón Cacabelos & Clara Torrellas. (2014) Epigenetic drug discovery for Alzheimer’s disease. Expert Opinion on Drug Discovery 9:9, pages 1059-1086.
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Kanwaljit Chopra, Shubham Misra & Anurag Kuhad. (2011) Neurobiological aspects of Alzheimer's disease. Expert Opinion on Therapeutic Targets 15:5, pages 535-555.
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Ramón Cacabelos. (2009) Pharmacogenomics and therapeutic strategies for dementia. Expert Review of Molecular Diagnostics 9:6, pages 567-611.
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