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Review

Fixed combinations in the management of hypertension: patient perspectives and rationale for development and utility of the olmesartan – amlodipine combination

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Pages 653-664 | Published online: 06 Jun 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Norio Susa, Yayoi Nishida, Yoichi Yada, Tomohiro Nakayama, Satoshi Asai & Yasuo Takahashi. (2016) Comparative effect of fixed-dose combination tablets of candesartan cilexetil/amlodipine versus olmesartan medoxomil/azelnidipine on laboratory parameters in patients with hypertension: a retrospective cohort study. Clinical and Experimental Hypertension 38:2, pages 173-179.
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Soo-Yun Lee, Jung-Ryul Kim, Jin Ah Jung, Wooseong Huh, Mi Young Bahng & Jae-Wook Ko. (2015) Bioequivalence evaluation of two amlodipine salts, besylate and orotate, each in a fixed-dose combination with olmesartan in healthy subjects. Drug Design, Development and Therapy 9, pages 2811-2817.
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E Van der Merwe & A Carboni. (2011) Strategies to improve blood pressure control and cardiovascular outcomes in hypertensive patients. South African Family Practice 53:6, pages 525-532.
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Jürgen Scholze, Angie Schaefer & Reinhold Kreutz. (2011) Safety and efficacy of olmesartan: an observational pooled-analysis of 156,682 hypertensive patients. Expert Opinion on Drug Safety 10:2, pages 185-196.
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C Venkata S Ram. (2011) Olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide triple combination for hypertension. Expert Review of Cardiovascular Therapy 9:1, pages 9-19.
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Eduardo Pimenta & Suzanne Oparil. (2010) Impact of olmesartan on blood pressure, endothelial function, and cardiovascular outcomes. Integrated Blood Pressure Control 3, pages 113-123.
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F. Zeng, B.V. Patel, L. Andrews, F. Frech-Tamas & A.E. Rudolph. (2010) Adherence and persistence of single-pill ARB/CCB combination therapy compared to multiple-pill ARB/CCB regimens. Current Medical Research and Opinion 26:12, pages 2877-2887.
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Alberto F Rubio-Guerra, David Castro-Serna, Cesar I Elizalde Barrera & Luz M Ramos-Brizuela. (2009) Current concepts in combination therapy for the treatment of hypertension: combined calcium channel blockers and RAAS inhibitors. Integrated Blood Pressure Control 2, pages 55-62.
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Christos Chatzikyrkou, Hermann Haller & Jan Menne. (2009) The role of fixed-dose combinations in the management of hypertension: focus on lercanidipine-enalapril. Expert Opinion on Pharmacotherapy 10:11, pages 1833-1840.
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Articles from other publishers (14)

Ashish Dash, Bikash R Meher, Biswa M Padhy, Rashmi R Mohanty & Amruta Tripathy. (2023) Comparison of Efficacy and Safety of Azilsartan and Amlodipine Combination Versus Telmisartan and Amlodipine Combination in Hypertensive Patients: A Non-inferiority Trial. Cureus.
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Ahmed Hemdan, Naser F. Al‐Tannak & Ekram H. Mohamed. (2021) Development of a multivariate model with desirability‐based optimization for determination of atenolol and hydrochlorothiazide by eco‐friendly HPLC method with fluorescence detection. Journal of Separation Science 45:4, pages 824-831.
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Josep Redon & Gernot Pichler. (2016) Comparative study of the efficacy of olmesartan/amlodipine vs. perindopril/amlodipine in peripheral blood pressure after missed dose in type 2 diabetes. Journal of Hypertension 34:2, pages 359-367.
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Peter Bramlage, Reinhard Ketelhut, Eva-Maria Fronk, Wolf-Peter Wolf, Rüdiger Smolnik, Claudia Zemmrich & Roland E. Schmieder. (2014) Clinical Impact of Patient Adherence to a Fixed-Dose Combination of Olmesartan, Amlodipine and Hydrochlorothiazide. Clinical Drug Investigation 34:6, pages 403-411.
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A. Lawrence Gould, S. Unniachan & D. Wu. (2014) Indirect treatment comparison between fixed-dose-combinations of amlodipine/losartan and amlodipine/valsartan in blood pressure control. International Journal of Clinical Practice 68:2, pages 163-172.
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Christian Ott, Markus P. Schneider & Roland E. Schmieder. (2013) Ruling out secondary causes of hypertension. EuroIntervention 9:R, pages R21-R28.
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Giuseppe Derosa, Arrigo F.G. Cicero, Anna Carbone, Fabrizio Querci, Elena Fogari, Angela D’Angelo & Pamela Maffioli. (2013) RETRACTED: Variation of some inflammatory markers in hypertensive patients after 1 year of olmesartan/amlodipine single-pill combination compared with olmesartan or amlodipine monotherapies. Journal of the American Society of Hypertension 7:1, pages 32-39.
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Guillaume Bobrie. (2012) I-ADD Study: Assessment of Efficacy and Safety Profile of Irbesartan/Amlodipine Fixed-Dose Combination Therapy Compared With Irbesartan Monotherapy in Hypertensive Patients Uncontrolled With Irbesartan 150 mg Monotherapy: A Multicenter, Phase III, Prospective, Randomized, Open-Label With Blinded–End Point Evaluation Study. Clinical Therapeutics 34:8, pages 1720-1734.e3.
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Guillaume Bobrie. (2012) I-COMBINE Study: Assessment of Efficacy and Safety Profile of Irbesartan/Amlodipine Fixed-Dose Combination Therapy Compared With Amlodipine Monotherapy in Hypertensive Patients Uncontrolled With Amlodipine 5 mg Monotherapy: A Multicenter, Phase III, Prospective, Randomized, Open-Label With Blinded–End Point Evaluation Study. Clinical Therapeutics 34:8, pages 1705-1719.
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Manish Maladkar, Vijay Kumar Verma, Keshav A. Narsikar, Rajan D. Walinjkar, W. R. Patil, N. J. S. Saggu & Suresh P. Kulkarni. (2012) Triple drug combination of telmisartan, amlodipine and hydrochlorothiazide in the treatment of essential hypertension. Open Journal of Internal Medicine 02:02, pages 67-71.
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M. Belén Ferro-Rey, Alex Roca-Cusachs, Antoni Sicras-Mainar, Carlos Álvarez-Martín & Marina de Salas-Cansado. (2011) Las combinaciones fijas en hipertensión: análisis de impacto presupuestario para el Sistema Nacional de Salud Español de la comercialización de la combinación fija de olmesartan/amlodipino. Atención Primaria 43:7, pages 345-355.
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Eduardo Pimenta. (2010) Increasing adherence: is that enough?. Hypertension Research 33:5, pages 411-413.
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Xavier Borrás, Nekane Murga, Miquel Fiol & Milagros Pedreira. (2010) Novedades en cardiología clínica: electrocardiografía de superficie, enfermedad vascular y mujer y novedades terapéuticas. Revista Española de Cardiología 63, pages 3-16.
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Christos ChatzikyrkouHermann HallerJan Menne. (2009) Efficacy and safety of fixed-dose Lercanidipine-Enalapril for the treatment of hypertension. Clinical Medicine. Therapeutics 1, pages CMT.S2315.
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