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Review

Vildagliptin: a new oral treatment for type 2 diabetes mellitus

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Pages 1349-1360 | Published online: 05 Dec 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Ibrahim Gueler, Susanne Mueller, Matthias Helmschrott, Christian U Oeing, Christian Erbel, Lutz Frankenstein, Christian Gleißner, Arjang Ruhparwar, Philipp Ehlermann, Thomas J Dengler, Hugo A Katus & Andreas O Doesch. (2013) Effects of vildagliptin (Galvus®) therapy in patients with type 2 diabetes mellitus after heart transplantation. Drug Design, Development and Therapy 7, pages 297-303.
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Amit S Kalgutkar & Deepak K Dalvie. (2012) Drug discovery for a new generation of covalent drugs. Expert Opinion on Drug Discovery 7:7, pages 561-581.
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Articles from other publishers (35)

GR Sridhar, Kaushik Pandit, Sona Warrier & Ashish Birla. (2023) Sustained-Release Vildagliptin 100 mg in Type 2 Diabetes Mellitus: A Review. Cureus.
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Siva Prasad Panda. (2023) Role of DPP4 and DPP4i in Glucose Homeostasis and Cardiorenal Syndrome. Endocrine, Metabolic & Immune Disorders - Drug Targets 23:2, pages 179-187.
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Katherine O. Kopp, Elliot J. Glotfelty, Yazhou Li & Nigel H. Greig. (2022) Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment. Pharmacological Research 186, pages 106550.
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Gadde Sathish Kumar, Prashant S. Shinde, Haifeng Chen, Krishnamoorthy Muralirajan, Rajesh Kancherla & Magnus Rueping. (2022) Paired Electrolysis for Decarboxylative Cyanation: 4-CN-Pyridine, a Versatile Nitrile Source. Organic Letters 24:35, pages 6357-6363.
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Sadia Malik, Nida Zaidi, Mohammad Khursheed Siddiqi, Nabeela Majid, Aiman Masroor, Samreen Salam & Rizwan H. Khan. (2022) Mechanistic insight into inhibition of amyloid fibrillation of human serum albumin by Vildagliptin. Colloids and Surfaces B: Biointerfaces 216, pages 112563.
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Mahaveer Sharma & S. S. Agrawal. (2021) Bioequivalence study of different brands of vildagliptin in healthy human subjects. Future Journal of Pharmaceutical Sciences 7:1.
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Basak Turk‐Erbul, Ecem F. Karaman, Gizem N. Duran, Mehmet Ozbil, Sibel Ozden & Fusun Goktas. (2021) Synthesis, in vitro cytotoxic and apoptotic effects, and molecular docking study of novel adamantane derivatives. Archiv der Pharmazie 354:5, pages 2000256.
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Dana Abdelrahim, MoezAlIslam E. Faris, Mohamed Hassanein, Ayman Z. Shakir, Ayesha M. Yusuf, Aljohara S. Almeneessier & Ahmed S. BaHammam. (2021) Impact of Ramadan Diurnal Intermittent Fasting on Hypoglycemic Events in Patients With Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials and Observational Studies. Frontiers in Endocrinology 12.
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Surendra Kumar. (2021) Comparison of safety and efficacy of glimepiride-metformin and vildagliptin- metformin treatment in newly diagnosed type 2 diabetic patients. Indian Journal of Endocrinology and Metabolism 25:4, pages 326.
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Akinsomisoye Olumide Stephen, Owolabi Adegbenga Rotimi, Azeez Taoreed Adegoke & Osuntokun Opeyemi Samson. (2021) Reprotoxic activities of vildagliptin administration in male Wistar rats. Brazilian Journal of Pharmaceutical Sciences 57.
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Päivi Maria Paldánius. (2020) Evaluating the Evidence behind the Novel Strategy of Early Combination from Vision to Implementation. Diabetes & Metabolism Journal 44:6, pages 785-801.
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David Matthews, Stefano Del Prato, Viswanathan Mohan, Chantal Mathieu, Sergio Vencio, Juliana C. N. Chan, Michael Stumvoll & Päivi Maria Paldánius. (2020) Insights from VERIFY: Early Combination Therapy Provides Better Glycaemic Durability Than a Stepwise Approach in Newly Diagnosed Type 2 Diabetes. Diabetes Therapy 11:11, pages 2465-2476.
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Malgorzata Sztiller-Sikorska & Malgorzata Czyz. (2020) Parthenolide as Cooperating Agent for Anti-Cancer Treatment of Various Malignancies. Pharmaceuticals 13:8, pages 194.
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Noha H. Sayed, Nevine Fathy, Mona A. Kortam, Mostafa A. Rabie, Ahmed F. Mohamed & Ahmed S. Kamel. (2019) Vildagliptin Attenuates Huntington’s Disease through Activation of GLP-1 Receptor/PI3K/Akt/BDNF Pathway in 3-Nitropropionic Acid Rat Model. Neurotherapeutics 17:1, pages 252-268.
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Yulong Chen, Quanmin Li, Ying Han, Hongmei Ji, Mingjun Gu, Rongwen Bian, Weiguang Ding, Jian Cheng & Yiming Mu. (2019) Vildagliptin Versus α-Glucosidase Inhibitor as Add-On to Metformin for Type 2 Diabetes: Subgroup Analysis of the China Prospective Diabetes Study. Diabetes Therapy 11:1, pages 247-257.
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Eva Rahman Kabir, Mohammad Kawsar Sharif Siam & Nashrah Mustafa. (2019) Scaffold of N -(2-(2-(tosylcarbamoyl)hydrazinyl)ethyl)isonicotinamidereveals anticancer effects through selective inhibition of FAP . Scaffold of N -(2-(2-(tosylcarbamoyl)hydrazinyl)ethyl)isonicotinamidereveals anticancer effects through selective inhibition of FAP .
Avinash MishraMegan CrossAndreas HofmannMark J. CosterAbdul KarimAbdul Sattar. (2019) Identification of a Novel Scaffold for Inhibition of Dipeptidyl Peptidase-4. Journal of Computational Biology 26:12, pages 1470-1486.
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Kristine Senkane, Ekaterina V. Vinogradova, Radu M. Suciu, Vincent M. Crowley, Balyn W. Zaro, J. Michael Bradshaw, Ken A. Brameld & Benjamin F. Cravatt. (2019) The Proteome‐Wide Potential for Reversible Covalency at Cysteine. Angewandte Chemie International Edition 58:33, pages 11385-11389.
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Kristine Senkane, Ekaterina V. Vinogradova, Radu M. Suciu, Vincent M. Crowley, Balyn W. Zaro, J. Michael Bradshaw, Ken A. Brameld & Benjamin F. Cravatt. (2019) The Proteome‐Wide Potential for Reversible Covalency at Cysteine. Angewandte Chemie.
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Mi Seon Seo, Hongliang Li, Jin Ryeol An, In Duk Jung, Won-Kyo Jung, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Il-Whan Choi & Won Sun Park. (2018) Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle. Cardiovascular Toxicology 19:3, pages 244-254.
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Samar S. Khalaf, Mohamed M. Hafez, Eman T. Mehanna, Noha M. Mesbah & Dina M. Abo-Elmatty. (2019) Combined vildagliptin and memantine treatment downregulates expression of amyloid precursor protein, and total and phosphorylated tau in a rat model of combined Alzheimer’s disease and type 2 diabetes. Naunyn-Schmiedeberg's Archives of Pharmacology 392:6, pages 685-695.
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Mohamed M. El-Wekil, Khaled K. Abdelhady, Randa A. Abdel Salam & Ghada M. Hadad. (2019) Applications of Fourier transform infrared spectroscopic method for simultaneous quantitation of some hypoglycemic drugs in their binary mixtures. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 213, pages 249-253.
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Cyrus V. Desouza, Namita Gupta & Anery Patel. (2015) Cardiometabolic Effects of a New Class of Antidiabetic Agents. Clinical Therapeutics 37:6, pages 1178-1194.
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Muhammad Abdul-Ghani, Ralph A. DeFronzo & Roy Eldor. 2015. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus 686 708 .
D. Allan Butterfield, Fabio Di Domenico & Eugenio Barone. (2014) Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842:9, pages 1693-1706.
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Stalin Selvaraj, Sridharan Krishnaswamy, Venkappayya Devashya, Swaminathan Sethuraman & Uma Maheswari Krishnan. (2014) Flavonoid-Metal Ion Complexes: A Novel Class of Therapeutic Agents. Medicinal Research Reviews 34:4, pages 677-702.
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Anna Berteotti, Federica Vacondio, Alessio Lodola, Michele Bassi, Claudia Silva, Marco Mor & Andrea Cavalli. (2014) Predicting the Reactivity of Nitrile-Carrying Compounds with Cysteine: A Combined Computational and Experimental Study. ACS Medicinal Chemistry Letters 5:5, pages 501-505.
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Jayasankar Kosaraju, Vishakantha Murthy, Rizwan Basha Khatwal, Anil Dubala, Santhivardhan Chinni, Satish Kumar Muthureddy Nataraj & Duraiswamy Basavan. (2013) Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease. Journal of Pharmacy and Pharmacology 65:12, pages 1773-1784.
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Ralph A. DeFronzo, Roy Eldor & Muhammad Abdul-Ghani. (2013) Pathophysiologic Approach to Therapy in Patients With Newly Diagnosed Type 2 Diabetes. Diabetes Care 36:Supplement_2, pages S127-S138.
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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach & Dennis A. Smith. 2012. Reactive Drug Metabolites. Reactive Drug Metabolites 313 334 .
Paresh Ved & Samrat Shah. (2012) Evaluation of vildagliptin and fixed dose combination of vildagliptin and metformin on glycemic control and insulin dose over 3 months in patients with type 2 diabetes mellitus. Indian Journal of Endocrinology and Metabolism 16:7, pages 110.
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Claire H. Wilson & Catherine A. Abbott. 2011. Proteinases as Drug Targets. Proteinases as Drug Targets 1 43 .
Michael Haidinger, Johannes Werzowa, Hans-Christian Voigt, Johannes Pleiner, Gunar Stemer, Manfred Hecking, Dominik Döller, Walter H Hörl, Thomas Weichhart & Marcus D Säemann. (2010) A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation. Trials 11:1.
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Fraser F. Fleming, Lihua Yao, P. C. Ravikumar, Lee Funk & Brian C. Shook. (2010) Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore. Journal of Medicinal Chemistry 53:22, pages 7902-7917.
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Abd A. Tahrani, Milan K. Piya, Amy Kennedy & Anthony H. Barnett. (2010) Glycaemic control in type 2 diabetes: Targets and new therapies. Pharmacology & Therapeutics 125:2, pages 328-361.
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