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Future Lipidology Volume 3, 2008 - Issue 3
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Ceramide signaling in cancer and stem cells

Erhard BieberichInstitute of Molecular Medicine – GeneticsSchool of Medicine, Medical College of Georgia,1120 15th Street, Room CB-2803, GA30912USA Tel.: +1 706 721 9113; Fax: +1 706 721 8685 E-mail:[email protected]Correspondence[email protected]
Pages 273-300 | Published online: 18 Jan 2017

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Sweta Ghosh, Subir Kumar Juin, Suchandra Bhattacharyya Majumdar & Subrata Majumdar. (2021) Crucial role of glucosylceramide synthase in the regulation of stem cell‐like cancer cells in B16F10 murine melanoma. Molecular Carcinogenesis 60:12, pages 840-858.
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Antonia Piazzesi, Sumaiya Yasmeen Afsar & Gerhild Echten‐Deckert. (2021) Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance. Molecular Oncology 15:12, pages 3256-3279.
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Yuliya Fakhr, David N. Brindley & Denise G. Hemmings. (2021) Physiological and pathological functions of sphingolipids in pregnancy. Cellular Signalling 85, pages 110041.
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Wei Fan, Shuang Tang, Xiaojuan Fan, Yi Fang, Xiaojiang Xu, Leping Li, Jian Xu, Jian-Liang Li, Zefeng Wang & Xiaoling Li. (2021) SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B. eLife 10.
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Sweta Ghosh, Subir Kumar Juin & Subrata Majumdar. (2020) Cancer stem cells and ceramide signaling: the cutting edges of immunotherapy. Molecular Biology Reports 47:10, pages 8101-8111.
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Xiaolin Cheng & Jeremy C. Smith. (2019) Biological Membrane Organization and Cellular Signaling. Chemical Reviews 119:9, pages 5849-5880.
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Nadia Soudani, Rouba Hage-Sleiman, Walid Karam, Ghassan Dbaibo & Hassan Zaraket. (2019) Ceramide Suppresses Influenza A Virus Replication In Vitro . Journal of Virology 93:7.
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Tetsuro Ishii & Eiji Warabi. (2019) Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR). Antioxidants 8:3, pages 69.
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David C. Montrose & Lorenzo Galluzzi. 2019. Cellular Nutrient Utilization and Cancer. Cellular Nutrient Utilization and Cancer 1 26 .
Ana E. Ventura, Beatriz Mestre & Liana C. Silva. 2019. Bioactive Ceramides in Health and Disease. Bioactive Ceramides in Health and Disease 79 108 .
Kai On Chu, Kwok Ping Chan, Sun On Chan, Tsz Kin Ng, Vishal Jhanji, Chi Chiu Wang & Chi Pui Pang. (2018) Metabolomics of Green-Tea Catechins on Vascular-Endothelial-Growth-Factor-Stimulated Human-Endothelial-Cell Survival. Journal of Agricultural and Food Chemistry 66:48, pages 12866-12875.
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Erhard Bieberich. (2018) Sphingolipids and lipid rafts: Novel concepts and methods of analysis. Chemistry and Physics of Lipids 216, pages 114-131.
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Ha Nguyen, Ahmed Awad, Saman Shabani & Ninh Doan. (2018) Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges. Pharmaceutics 10:2, pages 45.
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Michele Lai, Natalia Realini, Marco La Ferla, Ilaria Passalacqua, Giulia Matteoli, Anand Ganesan, Mauro Pistello, Chiara Maria Mazzanti & Daniele Piomelli. (2017) Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Scientific Reports 7:1.
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Ninh B. Doan, Ha S. Nguyen, Andrew Montoure, Mona M. Al-Gizawiy, Wade M. Mueller, Shekar Kurpad, Scott D. Rand, Jennifer M. Connelly, Christopher R. Chitambar, Kathleen M. Schmainda & Shama P. Mirza. (2017) Acid ceramidase is a novel drug target for pediatric brain tumors. Oncotarget 8:15, pages 24753-24761.
Crossref
Hiromi Kurokawa, Hiromu Ito & Hirofumi Matsui. (2017) Monascus purpureus induced apoptosis on gastric cancer cell by scavenging mitochondrial reactive oxygen species. Journal of Clinical Biochemistry and Nutrition 61:3, pages 189-195.
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Jonathon Duffy, Ayse Sena Mutlu & Meng C. Wang. 2017. Ageing: Lessons from C. elegans. Ageing: Lessons from C. elegans 307 329 .
Guanghu Wang, Stefka D. Spassieva & Erhard Bieberich. 2018. Sphingosine-1-Phosphate. Sphingosine-1-Phosphate 153 171 .
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Hussain Mohamad Awwad, Carsten-Henning Ohlmann, Michael Stoeckle, Rasul Aziz, Juergen Geisel & Rima Obeid. (2016) Choline-phospholipids inter-conversion is altered in elderly patients with prostate cancer. Biochimie 126, pages 108-114.
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Sophia Airhart, W. Todd Cade, Hui Jiang, Andrew R. Coggan, Susan B. Racette, Kevin Korenblat, Catherine Anderson Spearie, Suzanne Waller, Robert O'Connor, Adil Bashir, Daniel S. Ory, Jean E. Schaffer, Eric Novak, Marsha Farmer, Alan D. Waggoner, Víctor G. Dávila-Román, Cylen Javidan-Nejad & Linda R. Peterson. (2016) A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study. The Journal of Clinical Endocrinology & Metabolism 101:2, pages 504-512.
Crossref
Timothy A. Couttas & Anthony S. Don. 2016. Lipid Signaling Protocols. Lipid Signaling Protocols 23 33 .
Xin Ying Lim, Russell Pickford & Anthony S. Don. 2016. Lipid Signaling Protocols. Lipid Signaling Protocols 11 22 .
Abdul Basit, Daniele Piomelli & Andrea Armirotti. (2015) Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS. Analytical and Bioanalytical Chemistry 407:17, pages 5189-5198.
Crossref
Manwen He, Shuai Guo & Zhili Li. (2015) In situ characterizing membrane lipid phenotype of breast cancer cells using mass spectrometry profiling. Scientific Reports 5:1.
Crossref
Michael B. Dinkins, Somsankar Dasgupta, Guanghu Wang, Gu Zhu, Qian He, Ji Na Kong & Erhard Bieberich. (2015) The 5XFAD Mouse Model of Alzheimer’s Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden. Journal of Alzheimer's Disease 46:1, pages 55-61.
Crossref
Timothy A. Couttas, Xin Y. Lim & Anthony S. Don. (2014) A Three-Step Assay for Ceramide Synthase Activity Using a Fluorescent Substrate and HPLC. Lipids 50:1, pages 101-109.
Crossref
Kuntal Halder, Sayantan Banerjee, Anamika Bose, Saikat Majumder & Subrata Majumdar. (2014) Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation. PLoS ONE 9:3, pages e91656.
Crossref
Hazem J. Abuhusain, Azadeh Matin, Qiao Qiao, Han Shen, Nupur Kain, Bryan W. Day, Brett W. Stringer, Benjamin Daniels, Maarit A. Laaksonen, Charlie Teo, Kerrie L. McDonald & Anthony S. Don. (2013) A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis. Journal of Biological Chemistry 288:52, pages 37355-37364.
Crossref
Samy Omri, Francine Behar-Cohen, Pierre-Raphaël Rothschild, Emmanuelle Gélizé, Laurent Jonet, Jean Claude Jeanny, Boubaker Omri & Patricia Crisanti. (2013) PKCζ Mediates Breakdown of Outer Blood-Retinal Barriers in Diabetic Retinopathy. PLoS ONE 8:11, pages e81600.
Crossref
Erhard Bieberich. (2012) It’s a Lipid’s World: Bioactive Lipid Metabolism and Signaling in Neural Stem Cell Differentiation. Neurochemical Research 37:6, pages 1208-1229.
Crossref
Zu-An Zhu, Zheng-Qiu Zhu, Hong-Xing Cai & Ying Liu. (2012) Reversion of Multidrug Resistance by SKI-II in SGC7901/DDP Cells and Exploration of Underlying Mechanisms. Asian Pacific Journal of Cancer Prevention 13:2, pages 625-631.
Crossref
Erhard Bieberich. 2012. Sphingosine-1-Phosphate. Sphingosine-1-Phosphate 177 192 .
Erhard Bieberich. (2010) There is More to a Lipid than just Being a Fat: Sphingolipid-Guided Differentiation of Oligodendroglial Lineage from Embryonic Stem Cells. Neurochemical Research 36:9, pages 1601-1611.
Crossref
Erhard Bieberich. (2011) Ceramide in Stem Cell Differentiation and Embryo Development: Novel Functions of a Topological Cell-Signaling Lipid and the Concept of Ceramide Compartments. Journal of Lipids 2011, pages 1-11.
Crossref
Zdzislaw M. Szulc, Aiping Bai, Jacek Bielawski, Nalini Mayroo, Doreen E. Miller, Hanna Gracz, Yusuf A. Hannun & Alicja Bielawska. (2010) Synthesis, NMR characterization and divergent biological actions of 2′-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorganic & Medicinal Chemistry 18:21, pages 7565-7579.
Crossref
G Wang & E Bieberich. (2010) Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development. Cell Death & Disease 1:5, pages e46-e46.
Crossref
Shay C. Phillips, Gemma Triola, Gemma Fabrias, Félix M. Goñi, Donald B. DuPré & M. Cecilia Yappert. (2009) cis - versus trans -Ceramides: Effects of the Double Bond on Conformation and H-Bonding Interactions . The Journal of Physical Chemistry B 113:46, pages 15249-15255.
Crossref

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