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Update on the efficacy and safety of combination ezetimibe plus statin therapy

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Pages 655-684 | Published online: 18 Jan 2017

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Elizabeth Marrett, Changgeng Zhao, Ning Jackie Zhang, Qiaoyi Zhang, Dena R Ramey, Joanne E Tomassini, Andrew M Tershakovec & David R Neff. (2014) Limitations of real-world treatment with atorvastatin monotherapy for lowering LDL-C in high-risk cardiovascular patients in the US. Vascular Health and Risk Management 10, pages 237-246.
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JoAnne M Foody, Peter P Toth, Andrew M Tershakovec, Thomas Musliner, Joanne E Tomassini, Robert S Lowe, David R Neff & Harry R Davis. (2014) Efficacy and safety of ezetimibe plus atorvastatin therapy. Clinical Lipidology 9:4, pages 441-470.
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JoAnne M Foody, Peter P Toth, Joanne E Tomassini, Shiva Sajjan, Dena R Ramey, David Neff, Andrew M Tershakovec, Henry Hu & Kaan Tunceli. (2013) Changes in LDL-C levels and goal attainment associated with addition of ezetimibe to simvastatin, atorvastatin, or rosuvastatin compared with titrating statin monotherapy. Vascular Health and Risk Management 9, pages 719-727.
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Alberico Catapano, Peter P Toth, Joanne E Tomassini & Andrew M Tershakovec. (2013) The efficacy and safety of ezetimibe coadministered with statin therapy in various patient groups. Clinical Lipidology 8:1, pages 13-41.
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Articles from other publishers (28)

Juying Qian, Zhanquan Li, Xuelian Zhang, Jiyan Chen, Chunhua Ding, Ping Yang, Yan Liu, Miao Shi, Xinru Ren & Junbo Ge. (2022) Efficacy and Tolerability of Ezetimibe/Atorvastatin Fixed-dose Combination Versus Atorvastatin Monotherapy in Hypercholesterolemia: A Phase III, Randomized, Active-controlled Study in Chinese Patients. Clinical Therapeutics 44:10, pages 1282-1296.
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Seyyed Mostafa Arabi, Mahla Chambari, Mahsa Malek-Ahmadi, Leila Sadat Bahrami, Vahid Hadi, Manfredi Rizzo & Amirhossein Sahebkar. (2022) The effect of statin therapy in combination with ezetimibe on circulating C-reactive protein levels: a systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology 30:5, pages 1597-1615.
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Won Dong Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han & Seung Up Kim. (2019) Combined use of rosuvastatin and ezetimibe improves hepatic steatosis in patients with dyslipidemia. European Journal of Gastroenterology & Hepatology 32:12, pages 1538-1544.
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Henrique Silvano Arruda, Iramaia Angelica Neri-Numa, Larissa Akemi Kido, Mário Roberto Maróstica Júnior & Glaucia Maria Pastore. (2020) Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases. Journal of Functional Foods 75, pages 104203.
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Andrea Pasta, Elena Formisano, Anna Laura Cremonini, Elio Maganza, Erika Parodi, Sabrina Piras & Livia Pisciotta. (2020) Diet and Nutraceutical Supplementation in Dyslipidemic Patients: First Results of an Italian Single Center Real-World Retrospective Analysis. Nutrients 12:7, pages 2056.
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Mikaiel Hajializade, Mehdi Moghtadaei, Alireza Mirzaei, Shadi Abdollahi Kordkandi, Pegah Babaheidarian, Hamidreza Pazoki-Toroudi & Ali Yeganeh. (2020) Significant effect of simvastatin and/or ezetimibe-loaded nanofibers on the healing of femoral defect: An experimental study. Materials Science and Engineering: C 111, pages 110861.
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Alberto J Lorenzatti & Peter P Toth. (2020) New Perspectives on Atherogenic Dyslipidaemia and Cardiovascular Disease. European Cardiology Review 15.
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Lili Gu, Yaqin Gong, Cheng Zhao, Yue Wang, Qinghua Tian, Gaoxin Lei, Yalin Liang, Wenfeng Zhao & Shuhua Tan. (2019) Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE−/− Mice. Molecules 24:22, pages 4140.
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Peter P. Toth. 2019. Comprehensive Cardiovascular Medicine in the Primary Care Setting. Comprehensive Cardiovascular Medicine in the Primary Care Setting 39 69 .
Evan Stein, Harold Bays, Michael Koren, Rebecca Bakker-Arkema & Charles Bisgaier. (2016) Efficacy and safety of gemcabene as add-on to stable statin therapy in hypercholesterolemic patients. Journal of Clinical Lipidology 10:5, pages 1212-1222.
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Peter P Toth, Michel Farnier, Joanne E Tomassini, JoAnne M Foody & Andrew M Tershakovec. (2016) Statin combination therapy and cardiovascular risk reduction. Future Cardiology 12:3, pages 289-315.
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Ngoc‐Anh Le, Joanne E. Tomassini, Andrew M. Tershakovec, David R. Neff & Peter W. F. Wilson. (2015) Effect of Switching From Statin Monotherapy to Ezetimibe/Simvastatin Combination Therapy Compared With Other Intensified Lipid‐Lowering Strategies on Lipoprotein Subclasses in Diabetic Patients With Symptomatic Cardiovascular Disease. Journal of the American Heart Association 4:10.
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D. Meeike Kusters, Maria Caceres, Mauricio Coll, Cynthia Cuffie, Claude Gagné, Marc S. Jacobson, Peter O. Kwiterovich, Raymond Lee, Robert S. Lowe, Rachid Massaad, Brian W. McCrindle, Thomas A. Musliner, Joseph Triscari & John J.P. Kastelein. (2015) Efficacy and Safety of Ezetimibe Monotherapy in Children with Heterozygous Familial or Nonfamilial Hypercholesterolemia. The Journal of Pediatrics 166:6, pages 1377-1384.e3.
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Olivier Descamps, Joanne E. Tomassini, Jianxin Lin, Adam B. Polis, Arvind Shah, Philippe Brudi, Mary E. Hanson & Andrew M. Tershakovec. (2015) Variability of the LDL-C lowering response to ezetimibe and ezetimibe + statin therapy in hypercholesterolemic patients. Atherosclerosis 240:2, pages 482-489.
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Harold E. Bays, Erluo Chen, Joanne E. Tomassini, Gail McPeters, Adam B. Polis & Joseph Triscari. (2015) Fixed-dose combination ezetimibe+atorvastatin lowers LDL-C equivalent to co-administered components in randomized trials: use of a dose-response model. Fundamental & Clinical Pharmacology 29:2, pages 209-218.
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Manish Dhall & A. K. Madan. (2014) Studies on urea co-inclusion complexes of simvastatin for improvement of pharmaceutical characteristics. Journal of Inclusion Phenomena and Macrocyclic Chemistry 81:1-2, pages 105-120.
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Shizuya Yamashita, Daisaku Masuda & Akifumi Matsuyama. 2015. Dyslipidemias. Dyslipidemias 465 481 .
Baishali M. Ambegaonkar, Diane Tipping, Adam B. Polis, Joanne E. Tomassini & Andrew M. Tershakovec. (2014) Achieving goal lipid levels with ezetimibe plus statin add-on or switch therapy compared with doubling the statin dose. A pooled analysis. Atherosclerosis 237:2, pages 829-837.
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Alberico L. Catapano, Michel Farnier, JoAnne M. Foody, Peter P. Toth, Joanne E. Tomassini, Philippe Brudi & Andrew M. Tershakovec. (2014) Combination therapy in dyslipidemia: Where are we now?. Atherosclerosis 237:1, pages 319-335.
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Michael A. Blazing, Robert P. Giugliano, Christopher P. Cannon, Thomas A. Musliner, Andrew M. Tershakovec, Jennifer A. White, Craig Reist, Amy McCagg, Eugene Braunwald & Robert M. Califf. (2014) Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population. American Heart Journal 168:2, pages 205-212.e1.
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Peter P. Toth, JoAnne M. Foody, Joanne E. Tomassini, Shiva G. Sajjan, Dena R. Ramey, David R. Neff, Andrew M. Tershakovec, X. Henry Hu & Kaan Tunceli. (2014) Therapeutic practice patterns related to statin potency and ezetimibe/simvastatin combination therapies in lowering LDL-C in patients with high-risk cardiovascular disease. Journal of Clinical Lipidology 8:1, pages 107-116.
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Harold E. Bays, Maurizio Averna, Claudio Majul, Dirk Muller-Wieland, Annamaria De Pellegrin, Hilde Giezek, Raymond Lee, Robert S. Lowe, Philippe Brudi, Joseph Triscari & Michel Farnier. (2013) Efficacy and Safety of Ezetimibe Added to Atorvastatin Versus Atorvastatin Uptitration or Switching to Rosuvastatin in Patients With Primary Hypercholesterolemia. The American Journal of Cardiology 112:12, pages 1885-1895.
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Ngoc‐Anh Le, Ran Jin, Joanne E. Tomassini, Andrew M. Tershakovec, David R. Neff & Peter W.F. Wilson. (2013) Changes in Lipoprotein Particle Number With Ezetimibe/Simvastatin Coadministered With Extended‐Release Niacin in Hyperlipidemic Patients. Journal of the American Heart Association 2:4.
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Paul Kah Hing Ling, Fernando Civeira, Andrei Gheorghe Dan, Mary E Hanson, Rachid Massaad, Celine Le Bailly De Tilleghem, Christopher Milardo & Joseph Triscari. (2012) Ezetimibe/simvastatin 10/40 mg versus atorvastatin 40 mg in high cardiovascular risk patients with primary hypercholesterolemia: a randomized, double-blind, active-controlled, multicenter study. Lipids in Health and Disease 11:1.
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Doralisa Morrone, William S. Weintraub, Peter P. Toth, Mary E. Hanson, Robert S. Lowe, Jianxin Lin, Arvind K. Shah & Andrew M. Tershakovec. (2012) Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: A pooled analysis of over 21,000 subjects from 27 clinical trials. Atherosclerosis 223:2, pages 251-261.
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Peter P. Toth, Christie M. Ballantyne, Michael H. Davidson, Joanne E. Tomassini, Dena Rosen Ramey, David Neff, Andrew M. Tershakovec, X. Henry Hu & Kaan Tunceli. (2012) Changes in prescription patterns before and after reporting of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression trial (ENHANCE) results and expected effects on low-density lipoprotein-cholesterol reduction. Journal of Clinical Lipidology 6:2, pages 180-191.
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Harry R. DavisJrJr, Andrew M. Tershakovec, Joanne E. Tomassini & Thomas Musliner. (2011) Intestinal sterol transporters and cholesterol absorption inhibition. Current Opinion in Lipidology 22:6, pages 467-478.
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Ujjaini Khanderia, Randolph E. Regal, Melvyn Rubenfire & Thomas Boyden. (2011) The ezetimibe controversy: implications for clinical practice. Therapeutic Advances in Cardiovascular Disease 5:4, pages 199-208.
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