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Reviews

Update on the efficacy and safety of combination ezetimibe plus statin therapy

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Pages 655-684 | Published online: 18 Jan 2017

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  • Bays HE, Conard S, Leiter LA et al.: Effect of ezetimibe added to atorvastatin on lipoprotein subclass cholesterol content in patients with higher versus lower triglyceride levels. J. Clin. Lipidol. 3(3), 224–225 (2009).
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  • Farnier M, Freeman MW, Macdonell G et al.: Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia. Eur. Heart J. 26(9), 897–905 (2005).
  • McKenney JM, Farnier M, Lo KW et al.: Safety and efficacy of long-term co-administration of fenofibrate and ezetimibe in patients with mixed hyperlipidemia. J. Am. Coll. Cardiol. 47(8), 1584–1587 (2006).
  • ▪ Describes the long-term (48-week) lipid-altering effect and safety of ezetimibe combined with fenofibrate.
  • Fazio S, Guyton J, Polis A et al.: Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia. Am. J. Cardiol. 105(4), 487–494 (2010).
  • ▪ Describes the long-term (64-week) study of the lipid-altering efficacy of ezetimibe/simvastatin in combination with extended-release Niaspan®.
  • Guyton JR, Brown BG, Fazio S, Polis A, Tomassini JE, Tershakovec AM: Lipidaltering efficacy and safety of ezetimibe/ simvastatin coadministered with extended- release niacin in patients with type Ila or type Ilb hyperlipidemia. J. Am. Coll. Cardiol. 51(16), 1564–1572 (2008).
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  • Yamamoto A, Harada-Shiba M, Endo M et al.: The effect of ezetimibe on serum lipids and lipoproteins in patients with homozygous familial hypercholesterolemia undergoing LDL-apheresis therapy. Atherosclerosis 186(1), 126–131 (2006).
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  • Lutjohann D, von Bergmann K, Sirah W et al.: Long-term efficacy and safety of ezetimibe 10 mg in patients with homozygous sitosterolemia: a 2-year, open-label extension study. Int. J. Clin. Prac. 62(10), 1499–1510 (2008).
  • ▪ Describes a 2-year study of the safety and lipid-modifying effectiveness of ezetimibe in patients with homozygous sitosterolemia.
  • Salen G, Starc T, Sisk CM, Patel SB: Intestinal cholesterol absorption inhibitor ezetimibe added to cholestyramine for sitosterolemia and xanthomatosis. Gastroenterology 130(6), 1853–1857 (2006).
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  • Toth PP, Maki K: A commentary on the implications of the ENHANCE (Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression) trial: Should ezetimibe move to the "back of the line" as a therapy for dyslipidemia? J. Clin. Lipidol. 2(5), 313–317 (2008).
  • ▪ Commentary on ENHANCE trial results in the context of other carotid intima-media thickening (cIMT) studies.
  • Smilde TJ, van Wissen S, Wollersheim H, Trip MD, Kastelein JJP, Stalenhoef AFH: Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 357(9256), 577–581 (2001).
  • Stein EA: Additional lipid lowering trials using surrogate measurements of atherosclerosis by carotid intima-media thickness: more clarity or confusion? J. Am. Coll. Cardiol. 52(25), 2206–2209 (2008).
  • ▪ Discusses the role of cIMT as a surrogate measure in light of cIMT trial results.
  • van Wissen S, Smilde TJ, Trip MD, Stalenhoef AFH, Kastelein JJP: Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia. Am. J. Cardiol. 95(2), 264–266 (2005).
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  • Fleg JL, Mete M, Howard BV et al.: Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in Type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial. J. Am. Coll. Cardiol. 52(25), 2198–2205 (2008).
  • ▪▪ Describes a substudy of the SANDS trial comparing the effect of statins with ezetimibe plus statins on cIMT.
  • Howard BV, Roman MJ, Devereux RB et al.: Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes – the SANDS randomized trial. JAMA 299(14), 1678–1689 (2008).
  • Taylor AJ, Villines TC, Stanek EJ et al.: Extended-release niacin or ezetimibe and carotid intima-media thickness. N. Engl. J. Med. 361(22), 2113–2122 (2009).
  • ▪▪ ARBITER 6 trial comparison of extended-release Niaspan and ezetimibe on cIMT.
  • Duivenvoorden R, Vergeer M, Kastelein JJP: Niacin compared with ezetimibe. N. Engl. J. Med. 362(11), 1046–1047 (2010).
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