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Essential fatty acids enhance free radical generation and lipid peroxidation toinduce apoptosis of tumor cells

Pages 463-489 | Published online: 18 Jan 2017

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Lili Song, Sisi Wen, Qin Ye, Heqiang Lou, Yadi Gao, Vivek K. Bajpai, María Carpena, Miguel-Angel Prieto, Jesus Simal-Gandara, Jianbo Xiao, Xianghe Meng & Jiasheng Wu. (2023) Advances on delta 5-unsaturated-polymethylene-interrupted fatty acids: Resources, biosynthesis, and benefits. Critical Reviews in Food Science and Nutrition 63:6, pages 767-789.
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Rasha Abu-Khudir, Gehan A. Ismail & Thoria Diab. (2021) Antimicrobial, Antioxidant, and Anti-Tumor Activities of Sargassum linearifolium and Cystoseira crinita from Egyptian Mediterranean Coast. Nutrition and Cancer 73:5, pages 829-844.
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Fei Wang, Miao Miao, Beiying Chen, Ruifang Wang, Bingjie Sun, Difeng Ren & Jun Lu. (2015) Antineoplastic activity of γ-linolenic acid extract from Spirulina platensis on HepG2 cells and its inhibition effect on platelet aggregation. Food and Agricultural Immunology 26:1, pages 97-108.
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Articles from other publishers (46)

Xianghe Meng, Jue Ding & Qin Ye. (2023) Silver ion assisted urea complexation for the enrichment of sciadonic acid from Torreya fargesii kernel oil. Biochemical Engineering Journal 197, pages 108970.
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Undurti N. Das. (2022) Pro- and anti-inflammatory bioactive lipids imbalance contributes to the pathobiology of autoimmune diseases. European Journal of Clinical Nutrition 77:6, pages 637-651.
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Zoe I. Day, Alyce J. Mayfosh, Marie-Claire Giel, Yuning Hong, Scott A. Williams, Jascinta P. Santavanond, Thomas F. Rau, Ivan K. Poon & Mark D. Hulett. (2022) Novel Formulation of Undecylenic Acid induces Tumor Cell Apoptosis. International Journal of Molecular Sciences 23:22, pages 14170.
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Poorani Rengachar, Anant Narayan Bhatt, Sailaja Polavarapu, Senthil Veeramani, Anand Krishnan, Monika Sadananda & Undurti N. Das. (2022) Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study. Biomolecules 12:6, pages 797.
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A. Preethika, Shipra Sonkusare & N. Suchetha Kumari. (2022) Single nucleotide polymorphism of fatty acid desaturase gene and breast cancer risk in estrogen receptor subtype. Gene 823, pages 146330.
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Undurti N. Das. (2022) Arachidonic Acid as Mechanotransducer of Renin Cell Baroreceptor. Nutrients 14:4, pages 749.
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Fatma AKBAY & Adem EROL. (2021) Bazı Çemen (Trigonella foenum-graecum L.) Genotiplerinin Vejetatif Aksam ve Tohumlarının Yağ Asit Komposizyonunun BelirlenmesiDetermination of Fatty Acid Composition of Some Fenugreek (Trigonella foenum-graecum L.) Genotypes Vegetative Parts and Seeds. Türk Doğa ve Fen Dergisi 10:2, pages 1-5.
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Yaxu Liang, Zhen Zhang, Jiayu Tu, Zhibo Wang, Xiaoxiao Gao, Kaiping Deng, M.A. El-Samahy, Peihua You, Yixuan Fan & Feng Wang. (2021) γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway. Journal of Agricultural and Food Chemistry 69:29, pages 8257-8267.
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Jie Gao, Zhengyang Zhang, Yanfang Liu, Zining Zhang, Ming Wang, Aihua Gong, Lin Xia, Xiang Liao, Dongqing Wang & Haitao Zhu. (2021) Stearoyl-CoA Desaturase 1 Potentiates Hypoxic plus Nutrient-Deprived Pancreatic Cancer Cell Ferroptosis Resistance. Oxidative Medicine and Cellular Longevity 2021, pages 1-14.
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Undurti N. Das. (2021) “Cell Membrane Theory of Senescence” and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications. Biomolecules 11:2, pages 241.
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Linling Gan, Zongjie Gan, Yanrong Dan, Yaowei Li, Peiming Zhang, Shanwen Chen, Zaijun Ye, Tao Pan, Chunmei Wan, Xuelian Hu & Yu Yu. (2021) Tetrazanbigen Derivatives as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Partial Agonists: Design, Synthesis, Structure–Activity Relationship, and Anticancer Activities. Journal of Medicinal Chemistry 64:2, pages 1018-1036.
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Undurti N. Das. 2021. Food Structure and Functionality. Food Structure and Functionality 235 248 .
Jessica L. H. Walters, Amanda L. Anderson, Sarah J. Martins da Silva, R. John Aitken, Geoffry N. De Iuliis, Jessie M. Sutherland, Brett Nixon & Elizabeth G. Bromfield. (2020) Mechanistic Insight into the Regulation of Lipoxygenase-Driven Lipid Peroxidation Events in Human Spermatozoa and Their Impact on Male Fertility. Antioxidants 10:1, pages 43.
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Zeyad D Nassar, Chui Yan Mah, Jonas Dehairs, Ingrid JG Burvenich, Swati Irani, Margaret M Centenera, Madison Helm, Raj K Shrestha, Max Moldovan, Anthony S Don, Jeff Holst, Andrew M Scott, Lisa G Horvath, David J Lynn, Luke A Selth, Andrew J Hoy, Johannes V Swinnen & Lisa M Butler. (2020) Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis. eLife 9.
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Agnieszka Białek, Małgorzata Jelińska, Małgorzata Białek, Tomasz Lepionka, Małgorzata Czerwonka & Marian Czauderna. (2020) The Effect of Diet Supplementation with Pomegranate and Bitter Melon on Lipidomic Profile of Serum and Cancerous Tissues of Rats with Mammary Tumours. Antioxidants 9:3, pages 243.
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Undurti N. Das. (2020) Bioactive lipids as modulators of immune check point inhibitors. Medical Hypotheses 135, pages 109473.
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Undurti N. Das. 2020. Reviews on New Drug Targets in Age-Related Disorders. Reviews on New Drug Targets in Age-Related Disorders 33 83 .
Undurti N. DasUndurti N. Das. 2020. Molecular Biochemical Aspects of Cancer. Molecular Biochemical Aspects of Cancer 207 235 .
Undurti N. DasUndurti N. Das. 2020. Molecular Biochemical Aspects of Cancer. Molecular Biochemical Aspects of Cancer 181 206 .
Undurti N. DasUndurti N. Das. 2020. Molecular Biochemical Aspects of Cancer. Molecular Biochemical Aspects of Cancer 159 179 .
Undurti N. DasUndurti N. Das. 2020. Molecular Biochemical Aspects of Cancer. Molecular Biochemical Aspects of Cancer 67 157 .
Undurti N. DasUndurti N. Das. 2020. Molecular Biochemical Aspects of Cancer. Molecular Biochemical Aspects of Cancer 1 40 .
Zeyu Wang, Cong Chen, Huan Liu, Dzmitry Hrynshpan, Tatsiana Savitskaya, Jianmeng Chen & Jun Chen. (2019) Effects of carbon nanotube on denitrification performance of Alcaligenes sp. TB: Promotion of electron generation, transportation and consumption. Ecotoxicology and Environmental Safety 183, pages 109507.
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Sweeta Akbari, Nour Hamid Abdurahman, Rosli Mohd Yunus, Oluwaseun Ruth Alara & Olalere Olusegun Abayomi. (2019) Extraction, characterization and antioxidant activity of fenugreek (Trigonella-Foenum Graecum) seed oil. Materials Science for Energy Technologies 2:2, pages 349-355.
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Undurti N. Das. (2019) Can Bioactive Lipids Augment Anti-cancer Action of Immunotherapy and Prevent Cytokine Storm?. Archives of Medical Research 50:6, pages 342-349.
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Undurti N. Das. (2019) Saturated Fatty Acids, MUFAs and PUFAs Regulate Ferroptosis. Cell Chemical Biology 26:3, pages 309-311.
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Mark Kevin P. Devanadera, Reuel M. Bennett, Kenshi Watanabe, Myla R. Santiago, Maria Cristina Ramos, Tsunehiro Aki & Gina R. Dedeles. (2019) Marine Oomycetes (<i>Halophytophthora</i> and <i>Salispina</i>): A Potential Source of Fatty Acids with Cytotoxic Activity Against Breast Adenocarcinoma Cells (MCF7). Journal of Oleo Science 68:12, pages 1163-1174.
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Anna Jakubczyk, Michał Świeca, Urszula Gawlik-Dziki & Dariusz Dziki. (2018) Nutritional potential and inhibitory activity of bread fortified with green coffee beans against enzymes involved in metabolic syndrome pathogenesis. LWT 95, pages 78-84.
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Anasuya Devi Hari, Vegi G. M. Naidu & Undurti N. Das. (2018) n-6 and n-3 Fatty acids and their metabolites augment inhibitory action of doxorubicin on the proliferation of human neuroblastoma (IMR-32) cells by enhancing lipid peroxidation and suppressing Ras, Myc , and Fos . BioFactors 44:4, pages 387-401.
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Sailaja Polavarapu, Bilikere S. Dwarakanath & Undurti N Das. (2018) Arachidonic acid activates extrinsic apoptotic pathway to enhance tumoricidal action of bleomycin against IMR-32 cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 132, pages 16-22.
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Undurti N. Das. (2018) Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review. Journal of Advanced Research 11, pages 43-55.
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Nelson Gomes, Fátima Fernandes, Áurea Madureira-Carvalho, Patrícia Valentão, Alexandre Lobo-da-Cunha, Gonçalo Calado & Paula Andrade. (2018) Profiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agents. Molecules 23:5, pages 1027.
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Faten K. Abd El-Hady, Kamel H. Shaker, Ahmed M. A. Souleman, Walid Fayad, Mohamed S. Abdel-Aziz, Ahmed A. Hamed, Carmine Iodice & Giuseppina Tommonaro. (2017) Comparative Correlation Between Chemical Composition and Cytotoxic Potential of the Coral-Associated Fungus Aspergillus sp. 2C1-EGY Against Human Colon Cancer Cells. Current Microbiology 74:11, pages 1294-1300.
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Caroline Morin, Enrique Rodríguez, Pierre Blier & Samuel Fortin. (2017) Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer. Marine Drugs 15:9, pages 283.
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Undurti N. Das. (2017) Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus?. Frontiers in Endocrinology 8.
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Noelia Nikoloff, Ana M. Pascua, Juan M. Anchordoquy, Juan P. Anchordoquy, Matías A. Sirini, Analia Seoane & Cecilia C. Furnus. (2017) Effect of eicosapentaenoic acid on bovine cumulus-oocyte complex in vitro. Cell Biology International 41:5, pages 505-513.
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R. Poorani, Anant N. Bhatt, B.S. Dwarakanath & Undurti N. Das. (2016) COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance. European Journal of Pharmacology 785, pages 116-132.
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S. Riedel, S. Abel, H-M. Burger, L. van der Westhuizen, S. Swanevelder & W.C.A. Gelderblom. (2016) Differential modulation of the lipid metabolism as a model for cellular resistance to fumonisin B1–induced cytotoxic effects in vitro. Prostaglandins, Leukotrienes and Essential Fatty Acids 109, pages 39-51.
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Chengcheng Zhang, Haining Yu, Xiaofeng Ni, Shengrong Shen & Undurti N. Das. (2015) Growth Inhibitory Effect of Polyunsaturated Fatty Acids (PUFAs) on Colon Cancer Cells via Their Growth Inhibitory Metabolites and Fatty Acid Composition Changes. PLOS ONE 10:4, pages e0123256.
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Undurti N. Das. (2014) Albumin to globulin ratio and/or plasma albumin in predicting long-term mortality. The American Journal of Surgery 208:1, pages 157-158.
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Hongzhou Meng, Yuzhen Shen, Junhui Shen, Feng Zhou, Shengrong Shen & Undurti N Das. (2013) Effect of n-3 and n-6 unsaturated fatty acids on prostate cancer (PC-3) and prostate epithelial (RWPE-1) cells in vitro. Lipids in Health and Disease 12:1.
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Jennifer H. Gunter, Phoebe L. Sarkar, Amy A. Lubik & Colleen C. Nelson. (2013) New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication. International Journal of Cell Biology 2013, pages 1-13.
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Terje Vasskog, Jeanette Andersen, Espen Hansen & Johan Svenson. (2012) Characterization and Cytotoxicity Studies of the Rare 21:4 n-7 Acid and Other Polyunsaturated Fatty Acids from the Marine Opisthobranch Scaphander lignarius, Isolated Using Bioassay Guided Fractionation. Marine Drugs 10:12, pages 2676-2690.
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Colin Cortie & Paul Else. (2012) Dietary Docosahexaenoic Acid (22:6) Incorporates into Cardiolipin at the Expense of Linoleic Acid (18:2): Analysis and Potential Implications. International Journal of Molecular Sciences 13:12, pages 15447-15463.
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Jennifer H. Gunter, Amy A. Lubik, Ian McKenzie, Michael Pollak & Colleen C. Nelson. (2012) The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer. Advances in Urology 2012, pages 1-11.
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Undurti N Das & N Madhavi. (2011) Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro. Lipids in Health and Disease 10:1, pages 159.
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