Advanced search
Publication Cover
Clinical Lipidology Volume 7, 2012 - Issue 5
Submit an article Journal homepage
1,390
Views
14
CrossRef citations to date
0
Altmetric
Reviews

Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions.

Julie. LessardCentre de Recherche de l’InstitutUniversitaire de Cardiologie & de Pneumologie de Québec, 2725 Chemin Sainte-Foy, Y2120 Québec, G1V 4G5, Canada
&
André. TchernofDépartement de Nutrition, Université Laval, 2725 Chemin Sainte-Foy, Y2120 Québec, G1V 4G5, CanadaCorrespondence[email protected]
Pages 587-596 | Published online: 18 Jan 2017

Citations (14)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Sofia Laforest, Jennifer Labrecque, Andréanne Michaud, Katherine Cianflone & André Tchernof. (2015) Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction. Critical Reviews in Clinical Laboratory Sciences 52:6, pages 301-313.
Read now
Julie Lessard, Sofia Laforest, Mélissa Pelletier, Mathieu Leboeuf, Line Blackburn & André Tchernof. (2014) Low abdominal subcutaneous preadipocyte adipogenesis is associated with visceral obesity, visceral adipocyte hypertrophy, and a dysmetabolic state. Adipocyte 3:3, pages 197-205.
Read now

Articles from other publishers (12)

Julia Sánchez-Ceinos, Rocío Guzmán-Ruiz, Oriol Alberto Rangel-Zúñiga, Jaime López-Alcalá, Elena Moreno-Caño, Mercedes Del Río-Moreno, Juan Luis Romero-Cabrera, Pablo Pérez-Martínez, Elsa Maymo-Masip, Joan Vendrell, Sonia Fernández-Veledo, José Manuel Fernández-Real, Jurga Laurencikiene, Mikael Rydén, Antonio Membrives, Raul M Luque, José López-Miranda & María M Malagón. (2021) Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease. eLife 10.
Crossref
Zwe-Ling Kong, Athira Johnson, Tzu-Ling Ting, Po-Jen Cheng & Chien-Feng Mao. (2021) Protective Effects of Echinacea purpurea Ethanol Extract on Male Reproductive Dysfunction in Obese Rats. Applied Sciences 11:5, pages 2392.
Crossref
Wen-Yu Hsiao, Su Myung Jung, Yuefeng Tang, John A. Haley, Rui Li, Huawei Li, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Chien-Min Hung, Amelia K. Luciano, Victoria DeMambro, Kathryn E. Wellen, Clifford J. Rosen, Lihua Julie Zhu & David A. Guertin. (2020) The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development. Cell Reports 33:1, pages 108223.
Crossref
Marie-Eve PichéAndré TchernofJean-Pierre Després. (2020) Obesity Phenotypes, Diabetes, and Cardiovascular Diseases. Circulation Research 126:11, pages 1477-1500.
Crossref
Wen-Yu Hsiao & David A. Guertin. (2019) De Novo Lipogenesis as a Source of Second Messengers in Adipocytes. Current Diabetes Reports 19:11.
Crossref
Kasiphak Kaikaew, Jacobie Steenbergen, Theo H van Dijk, Aldo Grefhorst & Jenny A Visser. (2019) Sex Difference in Corticosterone-Induced Insulin Resistance in Mice. Endocrinology 160:10, pages 2367-2387.
Crossref
Jennifer Labrecque, Andréanne Michaud, Marie-Frédérique Gauthier, Mélissa Pelletier, François Julien, Léonie Bouvet-Bouchard & André Tchernof. (2019) Interleukin-1β and prostaglandin-synthesizing enzymes as modulators of human omental and subcutaneous adipose tissue function. Prostaglandins, Leukotrienes and Essential Fatty Acids 141, pages 9-16.
Crossref
Martin Horak, Daniela Kuruczova, Filip Zlamal, Josef Tomandl & Julie Bienertova-Vasku. (2018) Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. Disease Markers 2018, pages 1-7.
Crossref
Yan Wang, Judith C. W. Mak, Mary Y. K. Lee, Aimin Xu & Mary S. M. Ip. (2018) Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation. Oxidative Medicine and Cellular Longevity 2018, pages 1-13.
Crossref
Xinxia Wang, Caihua Yu, Jie Feng, Jin Chen, Qin Jiang, Shihuan Kuang & Yizhen Wang. (2017) Depot-specific differences in fat mass expansion in WT and ob/ob mice . Oncotarget 8:28, pages 46326-46336.
Crossref
Julie Anne Côté, Mélanie Nadeau, Mathieu Leboeuf, Line Blackburn & André Tchernof. (2014) Adipose tissue diacylglycerol acyltransferase activity and blood lipoprotein triglyceride enrichment in women with abdominal obesity. Atherosclerosis 233:1, pages 172-177.
Crossref
Andréanne Michaud, Nicolas Lacroix-Pépin, Mélissa Pelletier, Marleen Daris, Laurent Biertho, Michel A. Fortier & André Tchernof. (2014) Expression of Genes Related to Prostaglandin Synthesis or Signaling in Human Subcutaneous and Omental Adipose Tissue: Depot Differences and Modulation by Adipogenesis. Mediators of Inflammation 2014, pages 1-13.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.