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Original Article

Melanin Capacity to Accumulate Drugs in the Internal Ear: A Study on Lidocaine, Bupivacaine and Chlorpromazine

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Pages 61-73 | Received 17 Jul 1978, Published online: 08 Jul 2009

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Esa Laurikainen, Xi Lin, Alfred L. Nuttall & David F. Dolan. (1997) The Mechanism and Site of Action of Lidocaine Hydrochloride in Guinea Pig. Acta Oto-Laryngologica 117:4, pages 523-528.
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Michael D. Szymanski, Kenneth R. Henry & Francisco O. Buchting. (1994) Albino and Pigmented Gerbil Auditory Function: Influence of Genotype and Gentamicin. Audiology 33:2, pages 63-72.
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E. Laurikainen, A. L. Nuttall, J. M. Miller, W. S. Quirk & E. Virolainen. (1992) Experimental Basis for Lidocaine Therapy in Cochlear Disorders. Acta Oto-Laryngologica 112:5, pages 800-809.
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John W. Conlee, Khader J. Abdul-Baqi, Geary A. McCandless & Donnell J. Creel. (1988) Effects of aging on normal hearing loss and noise-induced threshold shift in albino and pigmented guinea pigs. Acta Oto-Laryngologica 106:1-2, pages 64-70.
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GÖRan Laurell & Erik Borg. (1986) Cis-Platin Ototoxicity in Previously Noise-Exposed Guinea Pigs. Acta Oto-Laryngologica 101:1-2, pages 66-74.
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Peter W. P. Collins & Jenny M. Twine. (1985) The ototoxic effects of different doses of gentamicin on the cochlea of pigmented guinea pigs. British Journal of Audiology 19:4, pages 257-264.
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Berit Scott, Per Lindberg, Leif Lyttkens & Lennart Melin. (1985) Psychological Treatment of Tinnitus An Experimental Group Study. Scandinavian Audiology 14:4, pages 223-230.
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Sven-Anders Wästerström. (1985) Auditory Brainstem-Evoked Response After Single-Dose Injection of Lidocaine and Tocainide. Scandinavian Audiology 14:1, pages 41-45.
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Jerry L. Yanz, Laura R. Herr, De Wayne Townsend & Carl J. Witkop. (1985) The Questionable Relation between Cochlear Pigmentation and Noise-Induced Hearing Loss. Audiology 24:4, pages 260-268.
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B. Gratacap, R. Charachon & P. Stoebner. (1985) Results of an Ultrastructural Study Comparing Stria Vascularis with Organ of Corti in Guinea Pigs Treated with Kanamycin. Acta Oto-Laryngologica 99:3-4, pages 339-342.
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R. M. J. Ings. (1984) The Melanin Binding of Drugs and Its Implications. Drug Metabolism Reviews 15:5-6, pages 1183-1212.
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N. L. Carter, K. Keen, R. L. Waugh, N. Murray & V. G. Bulteau. (1981) The Relations of Eye Colour and Smoking to Noise-Induced Permanent Threshold Shift. Audiology 20:4, pages 336-346.
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K. Watanuki, M. Sato, Y. Kaku, S. Shinkawa, T. Shibahara, A. Miyoshi & K. Kawamoto. (1981) Reissners Membrane in Human Ears. Acta Oto-Laryngologica 91:1-6, pages 65-74.
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Kyle E. Rarey & Muriel D. Ross. (1980) The Sensitivity of Cochlear Albino Melanocytes to Horseradish Peroxidase. Acta Oto-Laryngologica 90:1-6, pages 74-81.
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Articles from other publishers (24)

Marcus Bülow, Norman Best, Sebastian Brugger, Steffen Derlien, Dana Loudovici-Krug & Christina Lemhöfer. (2022) The effect of lidocaine iontophoresis for the treatment of tinnitus: a systematic review. European Archives of Oto-Rhino-Laryngology 280:2, pages 495-503.
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Onyinyechi C. Ukaegbe & Denise A. Tucker. (2021) The Role of Eye Color in the Emergence of Tinnitus in Silence. International Archives of Otorhinolaryngology 26:03, pages e407-e413.
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João V. Paulin & Carlos F. O. Graeff. (2021) From nature to organic (bio)electronics: a review on melanin-inspired materials. Journal of Materials Chemistry C 9:41, pages 14514-14531.
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A. Bernardus Mostert. (2021) Melanin, the What, the Why and the How: An Introductory Review for Materials Scientists Interested in Flexible and Versatile Polymers. Polymers 13:10, pages 1670.
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Jacqueline M. Ogier, Paul J. Lockhart & Rachel A. Burt. (2020) Intravenously delivered aminoglycoside antibiotics, tobramycin and amikacin, are not ototoxic in mice. Hearing Research 386, pages 107870.
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Anna-Kaisa Rimpelä, Mika Reinisalo, Laura Hellinen, Evgeni Grazhdankin, Heidi Kidron, Arto Urtti & Eva M. del Amo. (2018) Implications of melanin binding in ocular drug delivery. Advanced Drug Delivery Reviews 126, pages 23-43.
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Jan Borovanský & Patrick A. Riley. 2011. Melanins and Melanosomes. Melanins and Melanosomes 343 381 .
Sokratis Trellakis, Juergen Lautermann & Goetz Lehnerdt. 2007. Tinnitus: Pathophysiology and Treatment. Tinnitus: Pathophysiology and Treatment 303 322 .
Sarvjit S Gill & Alec N Salt. (1997) Quantitative differences in endolymphatic calcium and endocochlear potential between pigmented and albino guinea pigs. Hearing Research 113:1-2, pages 191-197.
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Theo A. Peters, Wim Kuijpers, Edith L.G.M. Tonnaer, Goos N.P. van Muijen & Paul H.K. Jap. (1995) Distribution and features of melanocytes during inner ear development in pigmented and albino rats. Hearing Research 85:1-2, pages 169-180.
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John W. Conlee & Margaret L. Bennett. (1993) Turn-specific differences in the endocochlear potential between albino and pigmented guinea pigs. Hearing Research 65:1-2, pages 141-150.
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Helene Z. Hill. (1992) The function of melanin or six blind people examine an elephant. BioEssays 14:1, pages 49-56.
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John W. Conlee, Richard P. Jensen, Thomas N. Parks & Donnell J. Creel. (1991) Turn-specific and pigment-dependent differences in the stria vascularis of normal and gentamicin-treated albino and pigmented guinea pigs. Hearing Research 55:1, pages 57-69.
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R. M. Barr-Hamilton, L. M. Matheson & D. G. Keay. (2007) Ototoxicity of cis-platinum and its relationship to eye colour. The Journal of Laryngology & Otology 105:1, pages 7-11.
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Renato Bareggi, Vittorio Grill, Paola Narducci, Marina Zweyer, Lorenzo Tesei & Mario Russolo. (1990) Gentamicin ototoxicity: Histological and ultrastructural alterations after transtympanic administration. Pharmacological Research 22:5, pages 635-644.
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B. Gratacap, A. Attard, A. Laurent, P. Stoebner, D. Smirou & R. Charachon. (1989) Melanin in the inner ear. Archives of Oto-Rhino-Laryngology 246:5, pages 235-237.
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John W. Conlee, Sarvjit S. Gill, Phillip T. McCandless & Donnell J. Creel. (1989) Differential susceptibility to gentamicin ototoxicity between albino and pigmented guinea pigs. Hearing Research 41:1, pages 43-51.
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A.S. BREATHNACH. (2006) Extra‐Cutaneous Melanin. Pigment Cell Research 1:4, pages 234-237.
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Clifford L. Eastman, John S. Young & Laurence D. Fechter. (1987) Trimethyltin ototoxicity in albino rats. Neurotoxicology and Teratology 9:5, pages 329-332.
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T. SZÜTS, G. BÁTHORY & K. MAGYAR. 1986. Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism. Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism 399 405 .
Robert V. Harrison, Alan Palmer & Jean -Marie Aran. (1984) Some otological differences between pigmented and albino-type guinea pigs. Archives of oto-rhino-laryngology 240:3, pages 271-275.
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Gregory R. Bock & Karen P. Steel. (1984) Use of albino animals for auditory research. Hearing Research 13:2, pages 201-202.
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Surujdeen Persad, I. Aravindakshan Menon & Herbert F. Haberman. (2008) COMPARISON OF THE EFFECTS OF UV‐VISIBLE IRRADIATION OF MELANINS and MELANIN‐HEMATOPORPHYRIN COMPLEXES FROM HUMAN BLACK and RED HAIR. Photochemistry and Photobiology 37:1, pages 63-68.
Crossref
S.D. Comis & G. Leng. (1980) Kanamycin ototoxicity and pigmentation in the guinea pig. Hearing Research 3:3, pages 249-251.
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