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Acta Oto-Laryngologica Volume 89, 1980 - Issue 3-6
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Original Article

The Nature of the Ototoxic Actions of Ethacrynic Acid Upon the Mammalian Endolymph System: I. Functional Aspects

S. K. Bosher Ferens Institute of Otolaryngology, The Middlesex Hospital Medical School, University of London, London, England
Pages 407-418 | Received 08 May 1979, Published online: 08 Jul 2009

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P. Tran Ba Huy. (1994) Physiopathology of Peripheral Non-Meniere's Vestibular Disorders. Acta Oto-Laryngologica 114:sup513, pages 5-10.
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Shizuo Komune, Shigeki Wakizono, Takashi Nakagawa, Takashi Kimituki, Kazutaka Hisashi & Takuya Uemura. (1991) Ototoxic Effect of Potassium Canrenoate on the Guinea Pig Cochlea. Acta Oto-Laryngologica 111:4, pages 719-727.
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J. P. Griffin. (1988) Drug-induced ototoxicity. British Journal of Audiology 22:3, pages 195-210.
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Leonard P. Rybak & Craig Whitworth. (1986) Comparative Ototoxicity of Furosemide and Piretanide. Acta Oto-Laryngologica 101:1-2, pages 59-65.
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Ernest S. Harpur. (1982) The Pharmacology of Ototoxic Drugs. British Journal of Audiology 16:2, pages 81-93.
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K. Rejtö L. Pálfalvi & V. Komora. (1982) Pure-Tone and Speech Intelligibility Disturbances in Patients with Ototoxic Disorders. Audiology 21:2, pages 159-176.
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T. Konishi, A. N. Salt & P. E. Hamrick. (1982) Effects of exposure to noise on permeability to potassium of the endolymph-perilymph barrier in guinea pigs. Acta Oto-Laryngologica 94:1-6, pages 395-401.
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Kyle E. Rarey & Muriel D. Ross. (1982) A Survey of the Effects of Loop Diuretics on the Zonulae Occludentes of the Perilymph-Endolymph Barrier by Freeze Fracture. Acta Oto-Laryngologica 94:1-6, pages 307-316.
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Andrew Forge. (1981) Original Papers · Travaux originaux: Electron Microscopy of the Stria vascularis and Its Response to Etacrynic Acid: A Study Using Electron-Dense Tracers and Extracellular Surface Markers. Audiology 20:4, pages 273-289.
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R Thalmann, D. C. Marcus & I. Thalmann. (1981) Physiological Chemistry of Cochlear Duct. Acta Oto-Laryngologica 91:1-6, pages 535-540.
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Andrew Forge. (1981) Ultrastructure in the Stria Vascularis of the Guinea Pig following Intraperitoneal Injection of Ethacrynic Acid. Acta Oto-Laryngologica 92:1-6, pages 439-457.
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Articles from other publishers (51)

Choongheon Lee & Timothy A. Jones. (2018) Acute blockade of inner ear marginal and dark cell K + secretion: Effects on gravity receptor function. Hearing Research 361, pages 152-156.
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Choongheon Lee, J. Chris Holt & Timothy A. Jones. (2017) Effect of M-current modulation on mammalian vestibular responses to transient head motion. Journal of Neurophysiology 118:6, pages 2991-3006.
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Hitesh Patel, Xavier Lucas, Igor Bendik, Stefan Günther & Irmgard Merfort. (2015) Target Fishing by Cross‐Docking to Explain Polypharmacological Effects. ChemMedChem 10:7, pages 1209-1217.
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Robert Patuzzi. (2011) Ion flow in stria vascularis and the production and regulation of cochlear endolymph and the endolymphatic potential. Hearing Research 277:1-2, pages 4-19.
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Dalian Ding, Haiyan Jiang & Richard J. Salvi. (2010) Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid. Hearing Research 259:1-2, pages 16-23.
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John C Somberg & Janos Molnar. (2009) The Management of Acute Heart Failure and Diuretic Therapy. American Journal of Therapeutics 16:1, pages 93-97.
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David H. Ellison & Christopher S. Wilcox. 2008. Therapy in Nephrology & Hypertension. Therapy in Nephrology & Hypertension 388 411 .
Mark D. Okusa & David H. Ellison. 2008. Seldin and Giebisch's The Kidney. Seldin and Giebisch's The Kidney 1051 1094 .
Katsuhisa Ikeda. (2004) Gene-Based Deafness Research: Ion Transport and Hearing. The Tohoku Journal of Experimental Medicine 202:1, pages 1-11.
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W.P.L Hellier, S.A Wagstaff, S.J O’Leary & R.K Shepherd. (2002) Functional and morphological response of the stria vascularis following a sensorineural hearing loss. Hearing Research 172:1-2, pages 127-136.
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R. Dauman & D. Dulon. (2000) Ototoxicidad medicamentosa. EMC - Otorrinolaringología 29:1, pages 1-12.
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Crista L. Adamson & Robin L. Davis. (1999) Differentiation of cyst-forming stria vascularis tissues in vitro. Hearing Research 129:1-2, pages 111-127.
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Mark Souter & Andrew Forge. (1998) Intercellular junctional maturation in the stria vascularis: possible association with onset and rise of endocochlear potential. Hearing Research 119:1-2, pages 81-95.
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Maarten G. van Emst, Sjaak F.L. Klis & Guido F. Smoorenburg. (1997) Identification of the nonlinearity governing even-order distortion products in cochlear potentials. Hearing Research 114:1-2, pages 93-101.
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Katsuhisa Ikeda, Takeshi Oshima, Hiroshi Hidaka & Tomonori Takasaka. (1997) Molecular and clinical implications of loop diuretic ototoxicity. Hearing Research 107:1-2, pages 1-8.
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William J. Clerici, Kenneth Hensley, Debra L. DiMartino & D.Allan Butterfield. (1996) Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hearing Research 98:1-2, pages 116-124.
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Yi Long Ma, Kyle E. Rarey, Kenneth J. Gerhardt, Lisa M. Curtis & Leonard P. Rybak. (1996) Electrochemical potentials and potassium concentration profiles recorded from perilymph, endolymph and associated inner ear tissues in adrenalectomized rats. Hearing Research 96:1-2, pages 151-156.
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Susan L. Garetz & Jochen Schacht. 1996. Clinical Aspects of Hearing. Clinical Aspects of Hearing 116 154 .
Leonard P. Rybak, Craig Whitworth, Craig Morris, Vernedra Scott & Hidetaka Kanno. (1995) Cochlear effects of indacrinone are not altered by penicillin. Hearing Research 85:1-2, pages 122-126.
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Jean‐Marie Aran. (2016) Current perspectives on inner ear toxicity. Otolaryngology–Head and Neck Surgery 112:1, pages 133-144.
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P. K. Plinkert. 1995. Teil I: Referate. Teil I: Referate 53 115 .
Leonard P. Rybak. (1993) Ototoxicity of Loop Diuretics. Otolaryngologic Clinics of North America 26:5, pages 829-844.
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Leonard P. Rybak, Craig Whitworth, Aruna Weberg & Vernedra Scott. (1992) Effects of organic acids on the edema of the stria vascularis induced by furosemide. Hearing Research 59:1, pages 75-84.
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L.P. Rybak, C. Whitworth & V. Scott. (1990) Organic acids do not alter the cochlear effects of ethacrynic acid. Hearing Research 46:1-2, pages 95-99.
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May Y. Huang & Jochen Schacht. (2012) Drug-Induced Ototoxicity. Medical Toxicology and Adverse Drug Experience 4:6, pages 452-467.
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A Schrott, G Egg, O Lichtenberger, A Ernst & H.-J Mest. (1989) The time-course of furosemide-induced strial changes in guinea pigs after pretreatment with daltroban. Hearing Research 42:1, pages 17-22.
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Katsuhisa Ikeda & Tetsuo Morizono. (1989) Electrochemical profiles for monovalent ions in the stria vascularis: Cellular model of ion transport mechanisms. Hearing Research 39:3, pages 279-286.
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Yukio Muratsuka, Hiromi Ueda & Teruzo Konishi. (1989) Effects of sodium bromate on ionic concentrations and osmolalities of the cochlear fluids in guinea pigs. Hearing Research 39:3, pages 241-249.
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J. Syka. 1989. Progress in Sensory Physiology 9. Progress in Sensory Physiology 9 97 170 .
Charles M. Lazenby, Simon J. Lee, Ernest S. Harpur & Andreas Gescher. (1988) Glutathione depletion in the guinea pig and its effect on the acute cochlear toxicity of ethacrynic acid. Biochemical Pharmacology 37:19, pages 3743-3747.
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L.P. Rybak & C. Whitworth. (1988) Quinine reduces noxious cochlear effects of furosemide and ethacrynic acid. American Journal of Otolaryngology 9:5, pages 238-243.
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L. P. Rybak. (2007) Ototoxicity of ethacrynic acid. The Journal of Laryngology & Otology 102:6, pages 518-520.
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M. Anniko & R. Wr�blewski. (1988) Simultaneous investigations of elemental changes in individual cells of the stria vascularis and in endolymph. Archives of Oto-Rhino-Laryngology 244:6, pages 346-349.
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Leonard P. Rybak & Craig Whitworth. (1987) Ototoxicity of indacrinone is stereospecific. Hearing Research 31:2, pages 169-174.
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Mark E. Schneider, Douglas A. Cotanche, Douglas M. Fambrough, James C. Saunders & Franz M. Matschinsky. (1987) Immunocytochemical and quantitative studies of Na+,K+-ATPase distribution in the developing chick cochlea. Hearing Research 31:1, pages 39-53.
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Matti Anniko & Aron Sobin. (1987) Ethacrynic acid effects on the isolated inner ear: Evaluation of the ototoxic potential in an organ culture system. American Journal of Otolaryngology 8:1, pages 48-62.
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Andrew Forge. 1986. Basic and Applied Aspects of Noise-Induced Hearing Loss. Basic and Applied Aspects of Noise-Induced Hearing Loss 55 68 .
Andrew Forge. (1985) Cholesterol distribution in cells of the stria vascularis of the mammalian cochlea and some effects of ototoxic diuretics. Journal of Cell Science 79:1, pages 181-197.
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Margaret J. Hukee & Arndt J. DuvallIIIIII. (2022) Cochlear Vessel Permeability to Horseradish Peroxidase in the Normal and Acoustically Traumatized Chinchilla: A Reevaluation. Annals of Otology, Rhinology & Laryngology 94:3, pages 297-303.
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Simon J. Lee & Ernest S. Harpur. (1985) Abolition of the negative endocochlear potential as a consequence of the gentamicin—furosemide interaction. Hearing Research 20:1, pages 37-43.
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J. Syka & I. Melichar. (1985) The effect of loop diuretics upon summating potentials in the guinea pig. Hearing Research 20:3, pages 267-273.
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E. Lehnhardt. 1984. Verhandlungsbericht 1984 der Deutschen Gesellschaft für Hals- Nasen- Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Verhandlungsbericht 1984 der Deutschen Gesellschaft für Hals- Nasen- Ohren-Heilkunde, Kopf- und Hals-Chirurgie 58 218 .
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Shizuo Komune, Musan Huangfu & James B. SnowJr.Jr.. (1983) Mechanism of the Production of the Negative Endocochlear DC Potential in the Guinea Pig. Otolaryngology–Head and Neck Surgery 91:4, pages 427-434.
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P.Tran Ba Huy, C. Manuel, A. Meulemans, O. Sterkers, M. Wassef & C. Amiel. (1983) Ethacrynic acid facilitates gentamicin entry into endolymph of the rat. Hearing Research 11:2, pages 191-202.
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Eric J. Lien, Lawrence R. Lipsett & Linda L. Lien. (1983) STRUCTURE SIDE-EFFECT SORTING OF DRUGS VI. OTOTOXICITIES. Journal of Clinical Pharmacy and Therapeutics 8:1, pages 15-33.
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B. Maass, D. Ludwig, K. Mees, J. Krmpotić-Nemanić, V. Valković, J. Strutz, K.-D. Franke, H. Bornemann, E. Reale, W. K. Jung, F. J. Schön, W. Elies, P. Berg, H. Luckhaupt, G. Bertram, K.-G. Rose, C.-P. Fues, H. Heumann, E. Steinbach, D. Baumgarten, U. Reker, M. Walger, U. Schmidt, H. Wedel, J. J. Manni, S. Müller-Hermann, E. Löhle, E. Müller-Hermann, W. Kreisel, O. G. Neumann, W. Saeger, H. Rudert, R. Grossenbacher & Th. Spillmann. 1983. Teil II: Sitzungsbericht. Teil II: Sitzungsbericht 163 198 .
Teruzo Konishi. (1982) Ion and water control in cochlear endolymph. American Journal of Otolaryngology 3:6, pages 434-443.
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Leonard P. Rybak & Tetsuo Morizono. (1982) Effect of furosemide upon endolymph potassium concentration. Hearing Research 7:2, pages 223-231.
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