20
Views
62
CrossRef citations to date
0
Altmetric
Original Article

The Nature of the Ototoxic Actions of Ethacrynic Acid Upon the Mammalian Endolymph System: I. Functional Aspects

Pages 407-418 | Received 08 May 1979, Published online: 08 Jul 2009

References

  • Ahlström P., Thalmann I., Thalmann R., Ise I. Cyclic AMP and adenylate cyclase in the inner ear. Laryngoscope 1975; 85: 1241
  • Bosher S. K. The nature of the negative endo-cochlear potentials produced by anoxia and ethacrynic acid in the rat and guinea pig. J Physiol (Lond) 1979; 293: 329
  • Bosher S. K., Smith C., Warren R. L. The effects of ethacrynic acid upon the cochlear endolymph and stria vascularis. A preliminary report. Acta Otolaryngol (Stockh) 1973; 75: 184
  • Bosher S. K., Smith C., Warren R. L. Duration of the effects of a solitary dose of ethacrynic acid upon the endolymph system. Coch-leafunktion, H. Jakobi, P. Lotz. Wiss. B. Martin-Luther-Univ., Halle-Wittenb 1976; 298
  • Brummett R., Smith C. A., Ueno Y., Cameron S., Richter R. The delayed effects of ethacrynic acid on the stria vascularis of the guinea pig. Acta Otolaryngol (Stockh) 1977; 83: 98
  • Brusilow S. W., Gordes E. The mutual independence of the endolymphatic potential and the concentrations of sodium and potassium in endolymph. J Clin Invest 1973; 52: 2517
  • Burg M., Green N. Effect of ethacrynic acid on the thick ascending limb of Henle's loop. Kidney In-ternat 1973; 4: 301
  • Crifò S. Ototoxicity of sodium ethacrynate in the guinea pig. Arch Otorhinolaryngol 1973; 206: 27
  • Fox K. E., Brummett R. E. Protein binding of ethacrynic acid and its cysteine derivative in relation to depression of the cochlear potential in guinea pigs. Fed Proc 1974a; 33: 271
  • Fox K. E., Brummett R. E. Tissue distribution of 14C-ethacrynic acid and its l4C-cysteine adduct during depression of the cochlear potential in guinea pigs. Pharmacologist 1974b; 16: 287
  • Fox K. E., Brummett R. E. The relationship between the cytotoxicity of kanamycin and ethacrynic acid for mammalian cells in vitro and their ototoxicity in vivo. Acta Otolaryngol (Stockh) 1979; 87: 72
  • Hodgkin A. L., Katz B. The effect of sodium ions on the electrical activity of the giant axon of the squid. J Physiol (Lond) 1949; 108: 37
  • Johnstone B. M. Ion fluxes in the cochlea. Membranes and Ion Transport, E. E. Bittar. John Wiley, New York 1970; Vol. 3: 167
  • Konishi T., Mendelsohn M. Effect of ouabain on cochlear potentials and endolymph composition in guinea pigs. Acta Otolaryngol (Stockh) 1970; 69: 192
  • Kuijpers W. Na-K-ATPase activity in the cochlea of the rat during development. Acta Otolaryngol (Stockh) 1974; 78: 341
  • Kuijpers W., Bonting S. L. Studies on (Na+-K+)-activated ATPase. XXIV. Localization and properties of ATPase in the inner ear of the guinea pig. Biochim Biophys Acta 1969; 173: 477
  • Kuijpers W., Bonting S. L. The cochlear potentials. I. The effect of ouabain on the cochlear potentials of the guinea pig. Pflügers Arch 1970a; 320: 348
  • Kuijpers W., Bonting S. L. The cochlear potentials. II. The nature of the cochlear endolymphatic resting potential. Pflügers Arch 1970b; 320: 359
  • Kuijpers W., Wilberts D. P. C. The effect of ouabain and ethacrynic acid on ATPase activities in the inner ear of the rat and guinea pig. ORL 1976; 38: 321
  • Kusakari J., Ise I., Comegys T. H., Thalmann I., Thalmann R. Effect of ethacrynic acid, furo-semide, and ouabain upon the endolymphatic potential and upon high energy phosphates of the stria vascularis. Laryngoscope 1978; 88: 12
  • Kusakari J., Thalmann R. Effects of anoxia and ethacrynic acid upon ampullar endolymphatic potential and upon high energy phosphates in ampullar wall. Laryngoscope 1976; 86: 132
  • Matschinsky F. M., Thalmann R. Energy metabolism of the cochlear duct. Biochemical Mechanisms in Hearing and Deafness, M. M. Paparella. Charles C. Thomas, Springfield, III 1970; 265
  • Melichar I., Syka J. The effects of ethacrynic acid upon the potassium concentration in guinea pig cochlear fluids. Hearing Research 1978; 1: 35
  • Misrahy G. A., Hildreth K. M., Clark L. C., Shina-Barger E. W. Measurement of the pH of the endolymph in the cochlea of guinea pigs. Am J Physiol 1958; 194: 393
  • Paloheimo S., Thalmann R. Influence of “loop” diuretics upon Na+ K+-ATPase and adenylate cyclase of the stria vascularis. Arch Otorhinolaryngol 1977; 217: 347
  • Prazma J., Pecorak J. B. Ethacrynic acid. Effects on the cochlear potentials in normal and high blood oxygen. J Clin Invest 1975; 55: 840
  • van Rossum G. D. V., Ernst S. A. Effects of ethacrynic acid on ion transport and energy metabolism in slices of avian salt gland and of mammalian liver and kidney cortex. J Membrane Biol 1978; 43: 251
  • Sellick P. M., Bock G. R. Evidence for an electrogenic potassium pump as the origin of the positive component of the endocochlear potential. Pflugers Arch 1974; 352: 351
  • Sellick P. M., Johnstone B. M. Differential effects of ouabain and ethacrynic acid on the labyrinthine potentials. Pflugers Arch 1974; 352: 339
  • Sellick P. M., Johnstone B. M. Production and role of inner ear fluid. Prog Neurobiol 1975; 5: 337
  • Silverstein H., Yules R. B. The effect of diuretics on cochlear potentials and inner ear fluids. Laryngoscope 1971; 81: 873
  • Thalmann R., Kusakari J., Miyoshi T. Dysfunctions of energy releasing and consuming processes of the cochlea. Laryngoscope 1973; 83: 1690

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.