87
Views
75
CrossRef citations to date
0
Altmetric
Original Article

Barrier Systems in the Inner Ear

Pages 79-83 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Rahul Mittal, Stefanie A. Pena, Angela Zhu, Nicolas Eshraghi, Arian Fesharaki, Elijah J. Horesh, Jeenu Mittal & Adrien A. Eshraghi. (2019) Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 1312-1320.
Read now
Xu Liu, Mingshuang Li, Hugh Smyth & Feng Zhang. (2018) Otic drug delivery systems: formulation principles and recent developments. Drug Development and Industrial Pharmacy 44:9, pages 1395-1408.
Read now
S. K. Juhn, K. Ikeda, T. Morizono & M. Murphy. (1991) Pathophysiology of Inner Ear Fluid Imbalance. Acta Oto-Laryngologica 111:sup485, pages 9-14.
Read now

Articles from other publishers (72)

Thi Phuc Le, Yang Yu, Hyuk Chan Kwon, Sun-Ae Shin, Yong-Ho Park & Kang Moo Huh. (2023) Novel self-degradable prodrug blend thermogel for intratympanic drug delivery to treat inner ear diseases. Chemical Engineering Journal 476, pages 146726.
Crossref
Lena Zaubitzer, Nicole Rotter & Angela Schell. (2023) Intratympanale Medikamentenapplikation – Indikationen und Ablauf. Laryngo-Rhino-Otologie 102:09, pages 693-705.
Crossref
Ahmed Chah, Hanaa Elfakir, Meziane Larbi & Karim Belharet. (2023) Strategy for haptic-based guidance of soft magnetic particles in the cochlea. Strategy for haptic-based guidance of soft magnetic particles in the cochlea.
Housseyne Nadour, Alexis Bozorg Grayeli, Gérard Poisson & Karim Belharet. (2023) CochleRob: Parallel-Serial Robot to Position a Magnetic Actuator around a Patient’s Head for Intracochlear Microrobot Navigation. Sensors 23:6, pages 2973.
Crossref
M. Abbes, K. Belharet, M. Souissi, H. Mekki & G. Poisson. (2023) Design of a Robotized Magnetic Platform for Targeted Drug Delivery in the Cochlea. IRBM 44:1, pages 100728.
Crossref
Kwadwo Mfoafo, Rahul Mittal, Adrien Eshraghi, Yadollah Omidi & Hossein Omidian. (2023) Improved inner ear drug delivery using hydrogel carriers. Journal of Drug Delivery Science and Technology 79, pages 104086.
Crossref
Ahmed Chah, Hanaa Elfakir, Larbi Meziane & Karim Belharet. (2022) Soft ferromagnetic microrobot navigation in the cochlea using haptic assistance. Soft ferromagnetic microrobot navigation in the cochlea using haptic assistance.
Maurizio Barbara, Valerio Margani, Edoardo Covelli, Chiara Filippi, Luigi Volpini, Ola M. El-Borady, Maged El-Kemary, Saad Elzayat & Haitham H. Elfarargy. (2022) The Use of Nanoparticles in Otoprotection. Frontiers in Neurology 13.
Crossref
Manar Magdy, Enas Elmowafy, Mona Elassal & Rania A.H. Ishak. (2022) Localized drug delivery to the middle ear: Recent advances and perspectives for the treatment of middle and inner ear diseases. Journal of Drug Delivery Science and Technology 69, pages 103149.
Crossref
Yang Yu, Da Hae Kim, Eun Yeong Suh, Seong-Hun Jeong, Hyuk Chan Kwon, Thi Phuc Le, Yugyeong Kim, Sun-Ae Shin, Yong-Ho Park & Kang Moo Huh. (2022) Injectable glycol chitosan thermogel formulation for efficient inner ear drug delivery. Carbohydrate Polymers 278, pages 118969.
Crossref
A. Qnouch, V. Solarczyk, J. Verin, G. Tourrel, P. Stahl, F. Danede, J.F. Willart, P.E. Lemesre, C. Vincent, J. Siepmann & F. Siepmann. (2021) Dexamethasone-loaded cochlear implants: How to provide a desired “burst release”. International Journal of Pharmaceutics: X 3, pages 100088.
Crossref
S. Foth, S. Meller, S. De Decker & H.A. Volk. (2021) Unilateral decrease in inner ear signal in fluid-attenuated inversion recovery sequences in previously suspected canine idiopathic vestibular syndrome. The Veterinary Journal 277, pages 105748.
Crossref
Jinsong Hao & S. Kevin Li. 2021. Fundamentals of Drug Delivery. Fundamentals of Drug Delivery 377 392 .
Zipei Zhang, Xiyu Li, Wei Zhang & Daniel S. Kohane. (2020) Drug Delivery across Barriers to the Middle and Inner Ear. Advanced Functional Materials 31:44.
Crossref
Philippine Toulemonde, Michaël Risoud, Pierre Emmanuel Lemesre, Cyril Beck, Jean Wattelet, Meryem Tardivel, Juergen Siepmann & Christophe Vincent. (2021) Evaluation of the Efficacy of Dexamethasone-Eluting Electrode Array on the Post-Implant Cochlear Fibrotic Reaction by Three-Dimensional Immunofluorescence Analysis in Mongolian Gerbil Cochlea. Journal of Clinical Medicine 10:15, pages 3315.
Crossref
Dan Cristian Gheorghe, Adelina-Gabriela Niculescu, Alexandra Cătălina Bîrcă & Alexandru Mihai Grumezescu. (2021) Nanoparticles for the Treatment of Inner Ear Infections. Nanomaterials 11:5, pages 1311.
Crossref
Abdelrahman M. Helmy. (2021) Overview of recent advancements in the iontophoretic drug delivery to various tissues and organs. Journal of Drug Delivery Science and Technology 61, pages 102332.
Crossref
Tarik Kroubi, Karim Belharet & Kamal Bennamane. (2020) Tracking Strategy Based on Magnetic Sensors for Microrobot Navigation in the Cochlea. Tracking Strategy Based on Magnetic Sensors for Microrobot Navigation in the Cochlea.
Kathleen T. Yee, Biswas Neupane, Fengwei Bai & Douglas E. Vetter. (2020) Zika virus infection causes widespread damage to the inner ear. Hearing Research 395, pages 108000.
Crossref
Jinhui Zhang, Xiaohan Wang, Zhiqiang Hou, Lingling Neng, Jing Cai, Yunpei Zhang & Xiaorui Shi. (2020) Suppression of Connexin 43 Leads to Strial Vascular Hyper-Permeability, Decrease in Endocochlear Potential, and Mild Hearing Loss. Frontiers in Physiology 11.
Crossref
Pernilla Videhult Pierre, Jesper Edvardsson Rasmussen, Sahar Nikkhou Aski, Peter Damberg & Göran Laurell. (2020) High-Dose Furosemide Enhances the Magnetic Resonance Signal of Systemic Gadolinium in the Mammalian Cochlea. Otology & Neurotology 41:4, pages 545-553.
Crossref
Chang-Hee Kim, Jung Eun Shin & Jung Hwan Park. (2019) Dialysis disequilibrium syndrome revisited: Feeling “Disequilibrated” due to inner ear dyshomeostasis?. Medical Hypotheses 129, pages 109262.
Crossref
Eric C. Bielefeld & Megan J. Kobel. (2019) Advances and Challenges in Pharmaceutical Therapies to Prevent and Repair Cochlear Injuries From Noise. Frontiers in Cellular Neuroscience 13.
Crossref
Huba Kalász, Gellért Karvaly, Kamil Musilek, Kamil Kuca, Jung Young-Sik, Barbara Malawska, Ernest A. Adeghate, Syed M. Nurulain, Judit Szepesy, Tibor Zelles & Kornélia Tekes. (2019) Dose-Dependent Tissue Distribution of K117, a Bis-pyridinium Aldoxime, in Rats. The Open Medicinal Chemistry Journal 13:1, pages 1-6.
Crossref
Chang-Hee Kim & Ngoc Chien Pham. (2019) Density difference between perilymph and endolymph: A new hypothesis for light cupula phenomenon. Medical Hypotheses 123, pages 55-59.
Crossref
W. Amokrane, K. Belharet, M. Souissi, A. Bozorg Grayeli & A. Ferreira. (2018) Macro–micromanipulation platform for inner ear drug delivery. Robotics and Autonomous Systems 107, pages 10-19.
Crossref
Manel Abbes, Mouna Souissi, Karim Belharet, Hassen Mekki & Gerard Poisson. (2018) A Novel Remote-Center-of-Motion Serial Manipulator for Inner Ear Drug Delivery. A Novel Remote-Center-of-Motion Serial Manipulator for Inner Ear Drug Delivery.
Juanjuan GaoShihua WangQi TangXiaoxia LiYongli ZhangWenbin LiuZhiqiang GaoHua YangRobert Chunhua Zhao. (2018) In Vitro Survival of Human Mesenchymal Stem Cells is Enhanced in Artificial Endolymph with Moderately High Concentrations of Potassium. Stem Cells and Development 27:10, pages 658-670.
Crossref
E. Truy, N. Loundon, M. Marx, A. Farinetti, M. Risoud, P.-E. Lemesre, D. Gnansia, J. Siepmann, C. Vincent, N. Guevara, O. Macherey, E. Lescanne, J. Lebour, C. Parietti-Winkler, T. Pawelczyk, Y. Nguyen, M. Beliaeff, T. Van Den Abbeele, G. Lina-Granade, M. Kalamarides, O. Sterkers, D. Bernardeschi & V. Couloigner. 2018. Surdités. Surdités 115 154 .
Azaddien Zarrouk, Karim Belharet & Omar Tahri. (2017) Calibration of magnetic platform prototype for vision-based drugs delivery inside human cochlea. Calibration of magnetic platform prototype for vision-based drugs delivery inside human cochlea.
Guillaume Duret, Fred A. Pereira & Robert M. Raphael. (2017) Diflunisal inhibits prestin by chloride-dependent mechanism. PLOS ONE 12:8, pages e0183046.
Crossref
Walid Amokrane, Karim Belharet & Antoine Ferreira. 2017. Microbiorobotics. Microbiorobotics 21 36 .
Xiaorui Shi. (2016) Pathophysiology of the cochlear intrastrial fluid-blood barrier (review). Hearing Research 338, pages 52-63.
Crossref
M. Gehrke, J. Sircoglou, D. Gnansia, G. Tourrel, J.-F. Willart, F. Danede, E. Lacante, C. Vincent, F. Siepmann & J. Siepmann. (2016) Ear Cubes for local controlled drug delivery to the inner ear. International Journal of Pharmaceutics 509:1-2, pages 85-94.
Crossref
Naila El Kechai, Florence Agnely, Elisabeth Mamelle, Yann Nguyen, Evelyne Ferrary & Amélie Bochot. (2015) Recent advances in local drug delivery to the inner ear. International Journal of Pharmaceutics 494:1, pages 83-101.
Crossref
Lingling Neng, Jinhui Zhang, Ju Yang, Fei Zhang, Ivan A. Lopez, Mingmin Dong & Xiaorui Shi. (2015) Structural changes in thestrial blood–labyrinth barrier of aged C57BL/6 mice. Cell and Tissue Research 361:3, pages 685-696.
Crossref
Vishal Tandon, Woo Seok Kang, Abigail J. Spencer, Ernest S. Kim, Erin E. L. Pararas, Michael J. McKenna, Sharon G. Kujawa, Mark J. Mescher, Jason Fiering, William F. Sewell & Jeffrey T. Borenstein. (2015) Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform. Biomedical Microdevices 17:2.
Crossref
Gang Gao, Ya Liu, Chang-Hua Zhou, Ping Jiang & Jian-Jun Sun. (2015) Solid Lipid Nanoparticles Loaded with Edaravone for Inner Ear Protection After Noise Exposure. Chinese Medical Journal 128:2, pages 203-209.
Crossref
Wei Long, Shi-chang Zhang, Lu Wen, Lei Mu, Fan Yang & Gang Chen. (2014) In vivo distribution and pharmacokinetics of multiple active components from Danshen and Sanqi and their combination via inner ear administration. Journal of Ethnopharmacology 156, pages 199-208.
Crossref
B. ShapiroS. KulkarniA. NacevA. SarwarD. Preciado & D.A. Depireux. (2014) Shaping Magnetic Fields to Direct Therapy to Ears and Eyes. Annual Review of Biomedical Engineering 16:1, pages 455-481.
Crossref
Xuanyi Li, Xi Shi, Yuehua Qiao, Kailin Xu, Lingyu Zeng, Caiji Wang, Zhou Xu & Haichen Niu. (2014) Observation of permeability of blood–labyrinth barrier during cytomegalovirus-induced hearing loss. International Journal of Pediatric Otorhinolaryngology 78:7, pages 995-999.
Crossref
Ernest S. Kim, Erich Gustenhoven, Mark J. Mescher, Erin E. Leary Pararas, Kim A. Smith, Abigail J. Spencer, Vishal Tandon, Jeffrey T. Borenstein & Jason Fiering. (2014) A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control. Lab Chip 14:4, pages 710-721.
Crossref
Stacy HoVincenzo Pucci. 2013. Tissue Analysis for Drug Development. Tissue Analysis for Drug Development 56 68 .
Yi-Chen Pai & Chia-Fone Lee. (2013) Intratympanic steroid injection for inner ear disease. Tzu Chi Medical Journal 25:3, pages 146-149.
Crossref
Hongzhuo Liu, Jinsong Hao & Kevin S. Li. (2013) Current strategies for drug delivery to the inner ear. Acta Pharmaceutica Sinica B 3:2, pages 86-96.
Crossref
Lingling Neng, Fei Zhang, Allan Kachelmeier & Xiaorui Shi. (2012) Endothelial Cell, Pericyte, and Perivascular Resident Macrophage-Type Melanocyte Interactions Regulate Cochlear Intrastrial Fluid–Blood Barrier Permeability. Journal of the Association for Research in Otolaryngology 14:2, pages 175-185.
Crossref
J Li, L Yu, R Xia, F Gao, W Luo & Y Jing. (2013) Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison. The Journal of Laryngology & Otology 127:3, pages 239-245.
Crossref
Sejo Oh, Jeong-Im Woo, David J. Lim & Sung K. Moon. (2012) ERK2-Dependent Activation of c-Jun Is Required for Nontypeable Haemophilus influenzae -Induced CXCL2 Upregulation in Inner Ear Fibrocytes . The Journal of Immunology 188:7, pages 3496-3505.
Crossref
S. Krenzlin, C. Vincent, L. Munzke, D. Gnansia, J. Siepmann & F. Siepmann. (2012) Predictability of drug release from cochlear implants. Journal of Controlled Release 159:1, pages 60-68.
Crossref
Xiaorui Shi. (2011) Physiopathology of the cochlear microcirculation. Hearing Research 282:1-2, pages 10-24.
Crossref
Cecilia Engmér Berglin, Pernilla Videhult Pierre, Tobias Bramer, Katarina Edsman, Hans Ehrsson, Staffan Eksborg & Göran Laurell. (2011) Prevention of cisplatin-induced hearing loss by administration of a thiosulfate-containing gel to the middle ear in a guinea pig model. Cancer Chemotherapy and Pharmacology 68:6, pages 1547-1556.
Crossref
Chul Ho Jang, Yong Bum Cho, Jun Sung Kim, Sung Woo Cho, Hyung Chae Yang, Kee Hong Jung, Jae Young Kim, Cheol Hee Choi, Yong Lim, Haekyun Park & Sung In Kang. (2011) Effect of Ginkgo biloba extract on endotoxin-induced labyrinthitis. International Journal of Pediatric Otorhinolaryngology 75:7, pages 905-909.
Crossref
Dennis S Poe & Ilmari Pyykkö. (2011) Nanotechnology and the treatment of inner ear diseases. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 3:2, pages 212-221.
Crossref
Sarah N Bowe & Abraham Jacob. (2010) Round window perfusion dynamics: implications for intracochlear therapy. Current Opinion in Otolaryngology & Head & Neck Surgery 18:5, pages 377-385.
Crossref
Erin E. Leary Swan, Mark J. Mescher, William F. Sewell, Sarah L. Tao & Jeffrey T. Borenstein. (2008) Inner ear drug delivery for auditory applications. Advanced Drug Delivery Reviews 60:15, pages 1583-1599.
Crossref
Jeffrey L. Hendricks, Jennifer A. Chikar, Mark A. Crumling, Yehoash Raphael & David C. Martin. (2008) Localized cell and drug delivery for auditory prostheses. Hearing Research 242:1-2, pages 117-131.
Crossref
Matthew J. Carfrae, Adrian Holtzman, Fred Eames, Steven M. Parnes & Allison Lupinetti. (2008) 3 Tesla Delayed Contrast Magnetic Resonance Imaging Evaluation of Ménière's Disease. The Laryngoscope 118:3, pages 501-505.
Crossref
Michael S Hildebrand, Stephen S Newton, Samuel P Gubbels, Abraham M Sheffield, Amit Kochhar, Michelle G de Silva, Hans-Henrik M Dahl, Scott D Rose, Mark A Behlke & Richard JH Smith. (2008) Advances in Molecular and Cellular Therapies for Hearing Loss. Molecular Therapy 16:2, pages 224-236.
Crossref
Roney S Coimbra, Gérard Loquet & Stephen L Leib. (2007) Limited Efficacy of Adjuvant Therapy with Dexamethasone in Preventing Hearing Loss Due to Experimental Pneumococcal Meningitis in the Infant Rat. Pediatric Research 62:3, pages 291-294.
Crossref
Michael S. Hildebrand, Hans-Henrik M. Dahl, Jennifer Hardman, Bryony Coleman, Robert K. Shepherd & Michelle G. de Silva. (2005) Survival of Partially Differentiated Mouse Embryonic Stem Cells in the Scala Media of the Guinea Pig Cochlea. Journal of the Association for Research in Otolaryngology 6:4, pages 341-354.
Crossref
Michael S. Hildebrand, Michelle G. de Silva, Tuomas Klockars, C. Arturo Solares, Keiko Hirose, Jonathan D. Smith, Shutish C. Patel & Hans-Henrik M. Dahl. (2005) Expression of the carrier protein apolipoprotein D in the mouse inner ear. Hearing Research 200:1-2, pages 102-114.
Crossref
Andreas Ekborn, Johan Hansson, Hans Ehrsson, Staffan Eksborg, Inger Wallin, Gunnar Wagenius & G??ran Laurell. (2004) High-Dose Cisplatin With Amifostine: Ototoxicity and Pharmacokinetics. The Laryngoscope 114:9, pages 1660-1667.
Crossref
Dmitriy M. Niyazov, James C. Andrews, David Strelioff, Shantanu Sinha & Robert Lufkin. (2001) Diagnosis of Endolymphatic Hydrops In Vivo with Magnetic Resonance Imaging. Otology & Neurotology 22:6, pages 813-817.
Crossref
S Kastenbauer, M Klein, U Koedel & H.W Pfister. (2001) Reactive nitrogen species contribute to blood–labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat. Brain Research 904:2, pages 208-217.
Crossref
Yutaka Takumi, Atsushi Matsubara, Shigeki Tsuchida, Ole P. Ottersen, Hideichi Shinkawa & Shin-ichi Usami. (2001) Various glutathione S-transferase isoforms in the rat cochlea. Neuroreport 12:7, pages 1513-1516.
Crossref
Takehisa Saito, Zhi Jian Zhang, Masaharu Tokuriki, Toshio Ohtsubo, Ichiro Noda, Yoshiyuki Shibamori, Takehito Yamamoto & Hitoshi Saito. (2001) Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig. Neuroscience Letters 303:3, pages 189-192.
Crossref
Takehisa Saito, Zhi-Jian Zhang, Masaharu Tokuriki, Toshio Ohtsubo, Ichiro Noda, Yoshiyuki Shibamori, Takehito Yamamoto & Hitoshi Saito. (2001) Expression of multidrug resistance protein 1 (MRP1) in the rat cochlea with special reference to the blood–inner ear barrier. Brain Research 895:1-2, pages 253-257.
Crossref
Zhi-Jian Zhang, Takehisa Saito, Yuichi Kimura, Chizuru Sugimoto, Toshio Ohtsubo & Hitoshi Saito. (2000) Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood–inner ear barrier in mice. Brain Research 852:1, pages 116-126.
Crossref
Takehisa Saito, Zhi Jian Zhang, Hideaki Tsuzuki, Toshio Ohtsubo, Takechiyo Yamada, Takehito Yamamoto & Hitoshi Saito. (1997) Expression of P-glycoprotein in inner ear capillary endothelial cells of the guinea pig with special reference to blood–inner ear barrier. Brain Research 767:2, pages 388-392.
Crossref
Norma B. Slepecky. 1996. The Cochlea. The Cochlea 44 129 .
Naoki Inamura & Alec N. Salt. (1992) Permeability changes of the blood-labyrinth barrier measured in vivo during experimental treatments. Hearing Research 61:1-2, pages 12-18.
Crossref
Robert T. Binhammer. (1992) CSF Anatomy with Emphasis on Relations to Nasal Cavity and Labyrinthine Fluids. Ear, Nose & Throat Journal 71:7, pages 292-299.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.