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Original Article

Cytotoxic Effects on Hair Cells of Guinea Pig Cochlea Produced by Pneumolysin, the Thiol Activated Toxin of Streptococcus pneumoniae

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Pages 152-159 | Received 03 Jul 1992, Accepted 18 Aug 1992, Published online: 08 Jul 2009

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Read on this site (6)

Melissa E Sanders, Erin W Norcross, Quincy C Moore$suffix/text()$suffix/text(), Chinwendu Onwubiko, Lauren B King, Jonathan Fratkin & Mary E Marquart. (2008) A comparison of pneumolysin activity and concentration in vitro and in vivo in a rabbit endophthalmitis model. Clinical Ophthalmology 2:4, pages 793-800.
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Sebahattin Cureoglu, Patricia A. Schachern, Alessandra Rinaldo, Vladimir Tsuprun, Alfio Ferlito & Michael M. Paparella. (2005) Round window membrane and labyrinthine pathological changes: an overview. Acta Oto-Laryngologica 125:1, pages 9-15.
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Steven Juhn, Vladimir Tsuprun, Yun‐Woo Lee, Brian Hunter & Patricia Schachern. (2004) Interaction between middle and inner ears in otitis media. Audiological Medicine 2:3, pages 158-161.
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Farzin Robert Amaee, Spiro D. Comis, Michael P. Osborne, Shelley Drew & Michael J. Tarlow. (1997) Possible Involvement of Nitric Oxide in the Sensorineural Hearing Loss of Bacterial Meningitis. Acta Oto-Laryngologica 117:3, pages 329-336.
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Andrew Winter, Sarah Marwick, Michael Osborne, Spiro Comis, John Stephen & Michael Tarlow. (1996) Ultrastructural Damage to the Organ of Corti during Acute Experimental Escherichia coli and Pneumococcal Meningitis in Guinea Pigs. Acta Oto-Laryngologica 116:3, pages 401-407.
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Farzin Robert Amaee, Spiro D. Comis & Michael P. Osborne. (1995) NG-Methyl-l-Arginine Protects the Guinea Pig Cochlea from the Cytotoxic Effects of Pneumolysin. Acta Oto-Laryngologica 115:3, pages 386-391.
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Articles from other publishers (37)

Katherine L. Kruckow, Kevin Zhao, Dawn M.E. Bowdish & Carlos J. Orihuela. (2023) Acute organ injury and long-term sequelae of severe pneumococcal infections. Pneumonia 15:1.
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Joana M. Pereira, Shuying Xu, John M. Leong & Sandra Sousa. (2022) The Yin and Yang of Pneumolysin During Pneumococcal Infection. Frontiers in Immunology 13.
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Allister J. Loughran, Carlos J. Orihuela & Elaine I. Tuomanen. 2019. Gram-Positive Pathogens. Gram-Positive Pathogens 316 330 .
Allister J. Loughran, Carlos J. Orihuela & Elaine I. Tuomanen. (2019) Streptococcus pneumoniae : Invasion and Inflammation . Microbiology Spectrum 7:2.
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Michael Perny, Magdalena Solyga, Denis Grandgirard, Marta Roccio, Stephen L. Leib & Pascal Senn. (2017) Streptococcus pneumoniae-induced ototoxicity in organ of Corti explant cultures. Hearing Research 350, pages 100-109.
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Lea-Ann S. Kirkham, Selma P. Wiertsema, Karli J. Corscadden, Tulia Mateus, Gemma L. Mullaney, Guicheng Zhang, Peter C. Richmond & Ruth B. Thornton. (2017) Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides. Clinical and Vaccine Immunology 24:3.
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Vladimir Tsuprun, Sebahattin Cureoglu, Patricia A. Schachern, Patricia Ferrieri, David E. Briles, Michael M. Paparella & Steven K. Juhn. (2008) Role of Pneumococcal Proteins in Sensorineural Hearing Loss Due to Otitis Media. Otology & Neurotology 29:8, pages 1056-1060.
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M. Klein, U. Koedel, S. Kastenbauer & H.-W. Pfister. (2007) Nitrogen and Oxygen Molecules in Meningitis-Associated Labyrinthitis and Hearing Impairment. Infection 36:1, pages 2-14.
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Johann S. Braun, Olaf Hoffmann, Miriam Schickhaus, Dorette Freyer, Emilie Dagand, Daniela Bermpohl, Tim J. Mitchell, Ingo Bechmann & Joerg R. Weber. (2007) Pneumolysin Causes Neuronal Cell Death through Mitochondrial Damage. Infection and Immunity 75:9, pages 4245-4254.
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Damian N. Meli, Roney S. Coimbra, Dominik G. Erhart, Gerard Loquet, Caroline L. Bellac, Martin G. Täuber, Ulf Neumann & Stephen L. Leib. (2006) Doxycycline Reduces Mortality and Injury to the Brain and Cochlea in Experimental Pneumococcal Meningitis. Infection and Immunity 74:7, pages 3890-3896.
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Carlos J. Orihuela & Elaine Tuomanen. 2006. Gram-Positive Pathogens. Gram-Positive Pathogens 253 267 .
Tim J. Mitchell. 2006. The Comprehensive Sourcebook of Bacterial Protein Toxins. The Comprehensive Sourcebook of Bacterial Protein Toxins 680 699 .
Tim J. Mitchell. 2006. Hot Topics in Infection and Immunity in Children III. Hot Topics in Infection and Immunity in Children III 111 124 .
Elaine Tuomanen. 2006. The Prokaryotes. The Prokaryotes 149 162 .
Maryline Beurg, Aziz Hafidi, Liam Skinner, Graeme Cowan, Yannick Hondarrague, Tim J. Mitchell & Didier Dulon. (2005) The mechanism of pneumolysin-induced cochlear hair cell death in the rat. The Journal of Physiology 568:1, pages 211-227.
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Allen F. Ryan, Steven K. Juhn, Ali Andalibi, Lauren O. Bakaletz, Garth D. Ehrlich, Timothy T. K. Jung, Jian-Dong Li, Jizhen Lin & Christopher J. Post. (2016) 4C. Interaction between Middle Ear and Inner Ear in Otitis Media. Annals of Otology, Rhinology & Laryngology 114:1_suppl, pages 56-59.
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Robert A. Hirst, Bashir J. Mohammed, Timothy J. Mitchell, Peter W. Andrew & Christopher O'Callaghan. (2004) Streptococcus pneumoniae -Induced Inhibition of Rat Ependymal Cilia Is Attenuated by Antipneumolysin Antibody . Infection and Immunity 72:11, pages 6694-6698.
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Tim J. Mitchell. 2004. The Pneumococcus. The Pneumococcus 61 74 .
Mike Mulheran, Martin Wiselka & Mark N. Johnston. (2004) Evidence of Subtle Auditory Deficit in a Group of Patients Recovered from Bacterial Meningitis. Otology & Neurotology 25:3, pages 302-307.
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Timothy J. Mitchell. (2003) The pathogenesis of streptococcal infections: from Tooth decay to meningitis. Nature Reviews Microbiology 1:3, pages 219-230.
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Michael T. Falcone, Byron J. Gajewski & Patrick J. Antonelli. (2016) Hearing Loss with Stapedotomy in Otitis Media. Otolaryngology–Head and Neck Surgery 129:6, pages 666-673.
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David G. Baker. 2003. Natural Pathogens of Laboratory Animals. Natural Pathogens of Laboratory Animals 129 146 .
David G. Baker. 2003. Natural Pathogens of Laboratory Animals. Natural Pathogens of Laboratory Animals 341 376 .
Roland Nau & Helmut Eiffert. (2002) Modulation of Release of Proinflammatory Bacterial Compounds by Antibacterials: Potential Impact on Course of Inflammation and Outcome in Sepsis and Meningitis. Clinical Microbiology Reviews 15:1, pages 95-110.
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Patrick J. Antonelli, Russell D. Briggs & Kenneth J. Gerhardt. (2000) Hearing Preservation With Labyrinthine Ablation in Otitis Media. The Laryngoscope 110:5, pages 779-786.
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B.J Mohammed, T.J Mitchell, P.W Andrew, R.A Hirst & C O»Callaghan. (1999) The effect of the pneumococcal toxin, pneumolysin on brain ependymal cilia. Microbial Pathogenesis 27:5, pages 303-309.
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Jamie M. Rappaport, Samir M. Bhatt, Arthur M. Lauretano, Robert S. Kimura & Robert A. Levine. (2016) Electron Microscopic Temporal Bone Histopathology in Experimental Pneumococcal Meningitis. Annals of Otology, Rhinology & Laryngology 108:6, pages 537-547.
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G. SCOTT GIEBINK. (1999) Otitis Media: The Chinchilla Model1. Microbial Drug Resistance 5:1, pages 57-72.
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MERLE A. SANDE & MARTIN G. TÄUBER. (1999) Pneumococcal Meningitis: Current Pathophysiologic Concepts. Microbial Drug Resistance 5:4, pages 295-299.
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Janet E. Alexander, Anne M. Berry, James C. Paton, Jeffrey B. Rubins, Peter W. Andrew & Timothy J. Mitchell. (1998) Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microbial Pathogenesis 24:3, pages 167-174.
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A.J. Winter, S.D. Comis, M.P. Osborne, T.L. Hayward, J. Stephen & M.J. Tarlow. (1998) Ototoxicity resulting from intracochlear perfusion of Streptococcus pneumoniae in the guinea pig is modified by cefotaxime or amoxycillin pretreatment. Journal of Infection 36:1, pages 73-77.
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STEN HELLSTRÖM, PER-OLOF ERIKSSON, YONG-JOO YOON & ULF JOHANSSON. (1997) Interactions Between the Middle Ear and the Inner Ear: Bacterial Products. Annals of the New York Academy of Sciences 830:1 Immunologic D, pages 110-119.
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A J WinterS D ComisM P OsborneM J TarlowJ StephenP W AndrewJ HillT J Mitchell. (1997) A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. Infection and Immunity 65:11, pages 4411-4418.
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T.J. MITCHELL & P.W. ANDREW. (1997) Biological Properties of Pneumolysin. Microbial Drug Resistance 3:1, pages 19-26.
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James C. Paton. (1996) The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae. Trends in Microbiology 4:3, pages 103-106.
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F EngelR BlatzJ KellnerM PalmerU WellerS Bhadki. (1995) Breakdown of the round window membrane permeability barrier evoked by streptolysin O: possible etiologic role in development of sensorineural hearing loss in acute otitis media. Infection and Immunity 63:4, pages 1305-1310.
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C F RaynerA D JacksonA RutmanA DewarT J MitchellP W AndrewP J ColeR Wilson. (1995) Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa. Infection and Immunity 63:2, pages 442-447.
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