Advanced search
Publication Cover
Acta Oto-Laryngologica Volume 113, 1993 - Issue 2
Submit an article Journal homepage
19
Views
43
CrossRef citations to date
0
Altmetric
Original Article

Cytotoxic Effects on Hair Cells of Guinea Pig Cochlea Produced by Pneumolysin, the Thiol Activated Toxin of Streptococcus pneumoniae

S. D. Comis Department of Physiology, The Medical School, England
,
M. P. Osborne Department of Physiology, The Medical School, England
,
J. Stephen School of Biological Sciences, The University of Birmingham, England
,
M. J. Tarlow Department of Infection, The Medical School, England
,
T. L. Hayward Department of Physiology, The Medical School, England
,
T. J. Mitchell Department of Microbiology, University of Leicester, England
,
P. W. Andrew Department of Microbiology, University of Leicester, England
&
G. J. Boulnois Department of Microbiology, University of Leicester, England
 show all
Pages 152-159 | Received 03 Jul 1992, Accepted 18 Aug 1992, Published online: 08 Jul 2009

References

  • Kennedy W. A., Hoyt M. J., McCracken G. H. Pneumococcal meningitis and deafness. The role of corticosteroid therapy in children with pneumococcal meningitis. Am J Dis Child 1991; 145: 1374–8
  • Morizono T., Giebink G. S., Paparella M. M., Sikora M. A., Shea D. Sensorineural hearing loss in experimental otitis media due to Streptococcus pneumoniae. Arch Otolaryngol 1985; 111: 794–8
  • Smyth C. J., Duncan J. L. Thiol-activated (oxygen-labile) cytolysins. Bacterial toxins and cell membranes, J. Jeljaszewicz, T. Waldstrom. Academic Press, London and New York 1978; 129–83
  • Bhakdi S., Tranum-Jensen J. Damage to cell membranes by pore-forming bacterial cytolysins. Prog Allergy 1988; 40: 1–43
  • Johnson K. K. Cellular location of pneumolysin. FEMS Microbiol Lett 1987; 2: 243–5
  • Bernheimer A. W. Sulfhydryl activated toxins. Mechanisms in bacterial toxinology, A. W. Bernheimer. Wiley, New York 1976; 85–97
  • Feldman C., Munro N. C., Jeffrey P. K., et al. Pneumolysin induces the salient histologic features of pneumococcal infection in the rat lung in vivo. Am J Respir Cell Mol Biol 1991; 5: 416–23
  • Paton J. C., Lock R. A., Hansman D. J. Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae. Infect Immun 1983; 40: 548–52
  • Berry A. M., Yother J., Briles D. E., Hansman D., Paton J. C. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect Immun 1989; 57: 2037–42
  • Tarlow M. J., Comis S. D., Osborne M. P. Endotoxin induced damage to the cochlea in guinea pig. Arch Dis Child 1991; 66: 181–4
  • Paton J. C., Lock R. A., Lee C-J, et al. Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infect Immun 1991; 59: 2297–304
  • Osborne M. P., Comis S. D. High resolution scanning electron microscopy of stereocilia in the cochlea of normal, post-mortem and drug-treated guinea pigs. J Electr Microsc Tech 1990; 15: 45–60
  • Steinfort C., Wilson R., Mitchell T., et al. Effect of Streptococcus pneumoniae on human respiratory epithelium in vitro. Infect Immun 1989; 57: 2006–13
  • Lindsay J. R., Hinojosa R. The acoustic ganglion in profound sensorineural deafness. Evoked electrical activity in the auditory system, R. F. Naunton, C. Fernandez. Academic Press, London and New York 1978; 301–21
  • Comis S. D., Osborne M. P., Tarlow M. J. The effect of bacterial endotoxin upon the morphology of the tectorial membrane and stereocilia in the guinea pig cochlea. Scan Microsc 1992; 5: 1129–34
  • Hofman J. Bacterial endotoxins. Handbook of toxinology, W. T. Shier, D. Mebs. Marcel Dekker, New York and Basel 1990; 655–82
  • Huang M. H., Dulon D., Schacht J. S. Outer hair cells as potential targets of inflammatory mediators. Ann Otol Rhinol Laryngol 1990; 99: 35–8
  • Paparella M. M., Oda M., Hiraide F., Brady D. Pathology of sensorineural hearing loss in otitis media. Ann Otol 1972; 81: 632–47
  • Paton J. C., Rowan-Kelly B., Ferrante A. Activation of human complement by the pneumococcal toxin pneumolysin. Infect Immun 1984; 43: 1085–7
  • Ferrante A., Rowan-Kelly B., Paton J. C. Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin. Infect Immun 1984; 46: 585–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.