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International Journal of Neuroscience Volume 120, 2010 - Issue 12
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Research Article

Phoshphodiesterase-5 Inhibitors: Novel Weapons Against Alzheimer's Disease?

Behnam SabayanDepartment of Geriatrics and Gerontology, Leiden University Medical Center, Leiden, Netherlands
,
Nima ZamiriHealth Policy Research Center, Shiraz University of Medical Sciences, Shiraz, IranCorrespondence[email protected]
,
Sara FarshchizarabiInstitute of Medical Sciences, School of Graduate Studies, University of Toronto, Toronto, Canada
&
Behrang SabayanMedicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Pages 746-751 | Received 04 Aug 2010, Published online: 13 Oct 2010

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Yusufhan Yazir, Selen Polat, Tijen Utkan & Feyza Aricioglu. (2019) Role of the nitric oxide-soluble guanylyl cyclase pathway in cognitive deficits in streptozotocin-induced diabetic rats. Psychiatry and Clinical Psychopharmacology 29:1, pages 34-44.
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Robert A Kloner, Gary Comstock, Laurence A Levine, Steven Tiger & Vera J Stecher. (2011) Investigational noncardiovascular uses of phosphodiesterase-5 inhibitors. Expert Opinion on Pharmacotherapy 12:15, pages 2297-2313.
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Articles from other publishers (16)

A.E. Braun, J.E. Cowan, L.A. Hampson, J.M. Broering, A.M. Suskind & P.R. Carroll. (2023) Association Between Common Urologic Medications and Onset of Alzheimer’s Disease and Related Dementias in Men With Prostate Cancer Managed by Different Primary Treatment Modalities. Urology 182, pages 161-167.
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Ahmed K. ElHady, Dalia S. El-Gamil, Mohammad Abdel-Halim & Ashraf H. Abadi. (2023) Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives. Pharmaceuticals 16:9, pages 1266.
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Giovanni Ribaudo, Alberto Ongaro, Giuseppe Zagotto, Maurizio Memo & Alessandra Gianoncelli. (2020) Therapeutic Potential of Phosphodiesterase Inhibitors against Neurodegeneration: The Perspective of the Medicinal Chemist. ACS Chemical Neuroscience 11:12, pages 1726-1739.
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Li Liu, Huang Xu, Shumin Ding, Dongyan Wang, Guoqiang Song & Xianfeng Huang. (2019) Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer’s disease. Brain Research Bulletin 153, pages 223-231.
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Cristina Angeloni, Maria Cristina Barbalace & Silvana Hrelia. (2019) Icariin and Its Metabolites as Potential Protective Phytochemicals Against Alzheimer’s Disease. Frontiers in Pharmacology 10.
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Huan Wang & Haiyan Zhang. (2018) Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer’s Disease. ACS Chemical Neuroscience 10:2, pages 852-862.
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Taymour Mostafa. (2017) Non-Sexual Implications of Phosphodiesterase Type 5 Inhibitors. Sexual Medicine Reviews 5:2, pages 170-199.
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D G Kurbatov, G R Galstyan, Yu G Shvarts, R V Rozhivanov, S A Dubskiy & A E Lepetukhin. (2015) Evaluating of the phosphodiesterase inhibitor type 5 effectiveness in treatment of neurogenic erectile dysfunction in patients with DM type 1. Problems of Endocrinology 61:4, pages 24-28.
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Feng Jin, Qi-Hai Gong, Ya-Sha Xu, Li-Na Wang, Hai Jin, Fei Li, Li-Sheng Li, Yue-Ming Ma & Jing-Shan Shi. (2014) Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling. The International Journal of Neuropsychopharmacology 17:06, pages 871-881.
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Guner Ulak. (2014) Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice. Medical Science Monitor Basic Research 20, pages 15-21.
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Nilanjana Ph. D.Mahesh Thirunavukkarasu & Murugavel Ponnusamy. 2013. Cardiovascular Diseases. Cardiovascular Diseases 439 458 .
Agostino Palmeri, Lucia Privitera, Salvatore Giunta, Carla Loreto & Daniela Puzzo. (2013) Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory. Behavioural Brain Research 240, pages 11-20.
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Jole Fiorito, Faisal Saeed, Hong Zhang, Agnieszka Staniszewski, Yan Feng, Yitshak I. Francis, Sudha Rao, Devarshi M. Thakkar, Shi-Xian Deng, Donald W. Landry & Ottavio Arancio. (2013) Synthesis of quinoline derivatives: Discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 60, pages 285-294.
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Annerieke S.R. Sierksma, Kris Rutten, Sebastian Sydlik, Somayeh Rostamian, Harry W.M. Steinbusch, Daniel L.A. van den Hove & Jos Prickaerts. (2013) Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neuropharmacology 64, pages 124-136.
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Santiago A. Plano, Patricia V. Agostino, Horacio O. de la Iglesia & Diego A. Golombek. (2012) cGMP-Phosphodiesterase Inhibition Enhances Photic Responses and Synchronization of the Biological Circadian Clock in Rodents. PLoS ONE 7:5, pages e37121.
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Wanda Layman & Jian Zuo. (2012) An unheard benefit of phosphodiesterase inhibition. Nature Medicine 18:2, pages 206-207.
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