1,837
Views
68
CrossRef citations to date
0
Altmetric
Review Article

Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans

, , , , , & show all
Pages 14-22 | Received 16 Mar 2011, Accepted 11 Aug 2011, Published online: 16 Nov 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Saeed Akhtar. (2016) Vitamin D Status in South Asian Populations – Risks and Opportunities. Critical Reviews in Food Science and Nutrition 56:11, pages 1925-1940.
Read now
Y. Yang, X. Luo, X. Xie, F. Yan, G. Chen, W. Zhao, Z. Jiang, C. Fang & J. Shen. (2016) Influences of teriparatide administration on marrow fat content in postmenopausal osteopenic women using MR spectroscopy. Climacteric 19:3, pages 285-291.
Read now

Articles from other publishers (65)

Mikkel Bo Brent. (2023) Pharmaceutical treatment of bone loss: From animal models and drug development to future treatment strategies. Pharmacology & Therapeutics 244, pages 108383.
Crossref
Gabriele Gariffo, Vanna Bottai, Federico Falcinelli, Federico Di Sacco, Roberta Cifali, Elisa Troiano, Rodolfo Capanna, Nicola Mondanelli & Stefano Giannotti. (2023) Use of Teriparatide in preventing delayed bone healing and nonunion: a multicentric study on a series of 20 patients. BMC Musculoskeletal Disorders 24:1.
Crossref
Dean A. Houston, Louise A. Stephen, Soher N. Jayash, Katherine Myers, Kirsty Little, Mark Hopkinson, Andrew A. Pitsillides, Vicky E. MacRae, Jose Luis Millan, Katherine A. Staines & Colin Farquharson. (2022) Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery. Cell Biochemistry and Function 41:2, pages 189-201.
Crossref
V. A. Shahen, A. Schindeler, M. S. Rybchyn, C. M. Girgis, B. Mulholland, R. S. Mason, I. Levinger & T. C. Brennan-Speranza. (2023) Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone. Calcified Tissue International 112:4, pages 452-462.
Crossref
Sedinei Lopes Copatti, Sabrina Lencina Bonorino, Anieli da Costa Copatti, Chrystianne Barros Saretto, Fernando Schorr Grossl, Marzo Edir Da Silva-Grigoletto, Vanessa da Silva Corralo & Clodoaldo Antônio De Sá. (2022) Acute effects of the resistance exercise associated with different blood flow restriction pressures on bone remodeling biomarkers. Journal of Exercise Science & Fitness 20:2, pages 155-160.
Crossref
Lamya Karim, Andrea Kwaczala, Deepak Vashishth & Stefan Judex. (2021) Dose-dependent effects of pharmaceutical treatments on bone matrix properties in ovariectomized rats. Bone Reports 15, pages 101137.
Crossref
Gunnlaugur Pétur Nielsen, Andrew E. Rosenberg, Judith V. M. G. Bovée, Miriam A. Bredella & Judith A. Ferry. 2021. Tumors of the Bones and Joints. Tumors of the Bones and Joints 621 659 .
K. Eastman, M. Gerlach, I. Piec, J. Greeves & W. Fraser. (2021) Effectiveness of parathyroid hormone (PTH) analogues on fracture healing: a meta-analysis. Osteoporosis International 32:8, pages 1531-1546.
Crossref
Ann Bjørnshave, Simon Lykkeboe, Bolette Hartmann, Jens J. Holst, Kjeld Hermansen & Jakob Starup‐Linde. (2020) Effects of a whey protein pre‐meal on bone turnover in participants with and without type 2 diabetes—A post hoc analysis of a randomised, controlled, crossover trial. Diabetic Medicine 38:6.
Crossref
Leopold Henssler, Maximilian Kerschbaum, Moldakulov Z. Mukashevich, Markus Rupp & Volker Alt. (2021) Molecular enhancement of fracture healing - Is there a role for Bone Morphogenetic Protein-2, parathyroid hormone, statins, or sclerostin-antibodies?. Injury 52, pages S49-S57.
Crossref
Tori Czech & Moses O. Oyewumi. (2020) Overcoming barriers confronting application of protein therapeutics in bone fracture healing. Drug Delivery and Translational Research 11:3, pages 842-865.
Crossref
R. Winzenrieth, M.S. Ominsky, Y. Wang, L. Humbert & R.J. Weiss. (2021) Differential effects of abaloparatide and teriparatide on hip cortical volumetric BMD by DXA-based 3D modeling. Osteoporosis International 32:3, pages 575-583.
Crossref
Patricia Clark, Fernando Carlos Rivera, Lucía Méndez Sánchez, Carlos Fernando Mendoza Gutiérrez, Jessica Liliana Vargas Neri, Sandra Miriam Carrillo Vázquez, Daniel Xavier Xibillé Friedmann, Ariana Alvarado Ceballos, José Manuel Aguilera Zepeda, Víctor Mercado Cárdenas & Hilario Ávila Amengol. (2021) Severe osteoporosis: Principles for pharmacological therapy in Mexico. Reumatología Clínica (English Edition) 17:2, pages 97-105.
Crossref
Patricia Clark, Fernando Carlos Rivera, Lucía Méndez Sánchez, Carlos Fernando Mendoza Gutiérrez, Jessica Liliana Vargas Neri, Sandra Miriam Carrillo Vázquez, Daniel Xavier Xibillé Friedmann, Ariana Alvarado Ceballos, José Manuel Aguilera Zepeda, Víctor Mercado Cárdenas & Hilario Ávila Armengol. (2021) Osteoporosis severa: fundamentos para su terapia farmacológica en México. Reumatología Clínica 17:2, pages 97-105.
Crossref
Shakib Akhter, Abdul Rehman Qureshi, Hussein Ali El-Khechen, Anthony Bozzo, Moin Khan, Rakesh Patel, Mohit Bhandari & Ilyas Aleem. (2020) The efficacy of teriparatide on lumbar spine bone mineral density, vertebral fracture incidence and pain in post-menopausal osteoporotic patients: A systematic review and meta-analysis. Bone Reports 13, pages 100728.
Crossref
I. Yankova, A. Shinkov & R. Kovatcheva. (2020) Changes in Bone Metabolism and Structure in Primary Hyperparathyroidism. Acta Medica Bulgarica 47:4, pages 75-80.
Crossref
Dimitrios Agas, Andrea Amaroli, Giovanna Lacava, Toru Yanagawa & Maria Giovanna Sabbieti. (2020) Loss of p62 impairs bone turnover and inhibits PTH‐induced osteogenesis. Journal of Cellular Physiology 235:10, pages 7516-7529.
Crossref
Linda Sequeira, John Nguyen, Liyun Wang & Anja Nohe. (2020) A Novel Peptide, CK2.3, Improved Bone Formation in Ovariectomized Sprague Dawley Rats. International Journal of Molecular Sciences 21:14, pages 4874.
Crossref
M. A. Jackson, S. Ohlerth, P. Brink, O. Simon, M. Kummer & A. E. Fürst. (2018) Treatment of subchondral cystic lesions (SCLs) with parathyroid hormone peptide (PTH 1‐34 )‐enriched fibrin hydrogel in three different concentrations: A dose‐blinded, randomised study . Equine Veterinary Education 32:S10, pages 121-128.
Crossref
Chen Cui, Liwei Zheng, Yi Fan, Jun Zhang, Ruoshi Xu, Jing Xie & Xuedong Zhou. (2020) Parathyroid hormone ameliorates temporomandibular joint osteoarthritic‐like changes related to age. Cell Proliferation 53:4.
Crossref
Megan Roche, Geoff Abrams & Michael Fredericson. 2020. Stress Fractures in Athletes. Stress Fractures in Athletes 141 149 .
Sabrina Ehnert, Romina H. Aspera-Werz, Marc Ruoß, Steven Dooley, Jan G. Hengstler, Silvio Nadalin, Borna Relja, Andreas Badke & Andreas K. Nussler. (2019) Hepatic Osteodystrophy—Molecular Mechanisms Proposed to Favor Its Development. International Journal of Molecular Sciences 20:10, pages 2555.
Crossref
Joanna Rymuza, Michał Popow, Zuzanna Żurecka, Jerzy Przedlacki, Tomasz Bednarczuk & Piotr Miśkiewicz. (2018) Therapy of moderate-to-severe Graves’ orbitopathy with intravenous methylprednisolone pulses is not associated with loss of bone mineral density. Endocrine 64:2, pages 308-315.
Crossref
Pablo A Ureña-Torres, Marc Vervloet, Sandro Mazzaferro, Franck Oury, Vincent Brandenburg, Jordi Bover, Etienne Cavalier, Martine Cohen-Solal, Adrian Covic, Tilman B Drüeke, Elif Hindié, Pieter Evenepoel, João Frazão, David Goldsmith, Junichiro James Kazama, Mario Cozzolino & Ziad A Massy. (2019) Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease. Clinical Kidney Journal 12:2, pages 269-280.
Crossref
Sung-Jin Kim, Seok Jun Moon & Jeong Taeg Seo. (2019) Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling. International Journal of Oral Biology 44:1, pages 1-7.
Crossref
Jianru Yi, Li Mei, Xue Li, Wei Zheng, Yu Li & Zhihe Zhao. (2019) Effects of continuous and intermittent parathyroid hormone administration on midpalatal suture expansion in rats. Archives of Oral Biology 99, pages 161-168.
Crossref
Line Lundbaek Barnkob, Paul Michael Petersen, Jens Peter Nielsen & Jette Jakobsen. (2018) Vitamin D enhanced pork from pigs exposed to artificial UVB light in indoor facilities. European Food Research and Technology 245:2, pages 411-418.
Crossref
Jay R. Dave, Ankush M. Dewle, Suhas T. Mhaske, Prashant T. Phulpagar, Vikas L. Mathe, Supriya E. More, Ayesha A. Khan, Appala Venkata Ramana Murthy, Suwarna S. Datar, Ajay J. Jog, Megha Page & Geetanjali B. Tomar. (2019) Hydroxyapatite nanorods loaded with parathyroid hormone (PTH) synergistically enhance the net formative effect of PTH anabolic therapy. Nanomedicine: Nanotechnology, Biology and Medicine 15:1, pages 218-230.
Crossref
Michelle A. Jackson & Anton E. Fürst. 2019. Equine Surgery. Equine Surgery 1528 1542 .
Roy Morello. (2018) Osteogenesis imperfecta and therapeutics. Matrix Biology 71-72, pages 294-312.
Crossref
Harshika Awasthi, Dayanandan Mani, Divya Singh & Atul Gupta. (2018) The underlying pathophysiology and therapeutic approaches for osteoporosis. Medicinal Research Reviews 38:6, pages 2024-2057.
Crossref
Kelly J. Culhane, Morgan E. Belina, Jeremiah N. Sims, Yingying Cai, Yuting Liu, Pam S. P. Wang & Elsa C. Y. Yan. (2018) Parathyroid Hormone Senses Extracellular Calcium To Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor. ACS Chemical Biology 13:8, pages 2347-2358.
Crossref
GYUNGAH KIM, YOON MI JIN, YEONSIL YU, HA YEONG KIM, SANGMEE AHN JO, YOON JEONG PARK, YOON SHIN PARK & INHO JO. (2018) Double intratibial injection of human tonsil-derived mesenchymal stromal cells recovers postmenopausal osteoporotic bone mass. Cytotherapy 20:8, pages 1013-1027.
Crossref
Mikkel Bo Brent, Jesper Skovhus Thomsen & Annemarie Brüel. (2018) The effect of oral dabigatran etexilate on bone density, strength, and microstructure in healthy mice. Bone Reports 8, pages 9-17.
Crossref
Muhammad Shakib Akhter, Hussein Ali El-Khechen, Rakesh Patel & Ilyas S. Aleem. (2018) Can medical management with teriparatide improve spinal surgery outcomes in patients with spinal osteoporosis/osteopenia?. Seminars in Spine Surgery 30:1, pages 41-45.
Crossref
Mohd Nizam Mansoori, Priyanka Shukla & Divya Singh. (2017) Combination of PTH (1-34) with anti-IL17 prevents bone loss by inhibiting IL-17/N-cadherin mediated disruption of PTHR1/LRP-6 interaction. Bone 105, pages 226-236.
Crossref
Shu-Wen Kuo, Marilyn Rimando, Yi-Shiuan Liu & Oscar Lee. (2017) Intermittent Administration of Parathyroid Hormone 1–34 Enhances Osteogenesis of Human Mesenchymal Stem Cells by Regulating Protein Kinase Cδ. International Journal of Molecular Sciences 18:10, pages 2221.
Crossref
Sergio Portal-Núñez, Aranzazu Mediero, Pedro Esbrit, Olga Sánchez-Pernaute, Raquel Largo & Gabriel Herrero-Beaumont. (2017) Unexpected Bone Formation Produced by RANKL Blockade. Trends in Endocrinology & Metabolism 28:10, pages 695-704.
Crossref
Srilatha Swami, Joshua Johnson, Lance A. Bettinson, Takaharu Kimura, Hui Zhu, Megan A. Albertelli, Rachelle W. Johnson & Joy Y. Wu. (2017) Prevention of breast cancer skeletal metastases with parathyroid hormone. JCI Insight 2:17.
Crossref
Rabia Islam, Won-Joon Yoon & Hyun-Mo Ryoo. (2017) Pin1, the Master Orchestrator of Bone Cell Differentiation. Journal of Cellular Physiology 232:9, pages 2339-2347.
Crossref
Aline Bozec & Didier Soulat. (2017) Latest perspectives on macrophages in bone homeostasis. Pflügers Archiv - European Journal of Physiology 469:3-4, pages 517-525.
Crossref
Hye-Sun ParkDa Hea SeoYumie RheeSung-Kil Lim. (2017) Site-Specific Difference of Bone Geometry Indices in Hypoparathyroid Patients. Endocrinology and Metabolism 32:1, pages 68.
Crossref
L. Osagie-Clouard, A. Sanghani, M. Coathup, T. Briggs, M. Bostrom & G. Blunn. (2017) Parathyroid hormone 1-34 and skeletal anabolic action. Bone & Joint Research 6:1, pages 14-21.
Crossref
Kok-Yong Chin. (2017) A Review on the Relationship between Aspirin and Bone Health. Journal of Osteoporosis 2017, pages 1-8.
Crossref
David S. Ross, Khamir Mehta & Antonio Cabal. (2016) Mathematical Model of Bone Remodeling Captures the Antiresorptive and Anabolic Actions of Various Therapies. Bulletin of Mathematical Biology 79:1, pages 117-142.
Crossref
Katie Leach, Karen J Gregory, Irina Kufareva, Elham Khajehali, Anna E Cook, Ruben Abagyan, Arthur D Conigrave, Patrick M Sexton & Arthur Christopoulos. (2016) Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell Research 26:5, pages 574-592.
Crossref
Zheng-Long Tang, Shuo Bai, Peng-Na Zhu, Yong-Di Li, Dong-Xiang Wang & Yang Cai. (2016) An Examination of Differences in the New Bone Formation Promoted by Different Doses of Recombinant Human Parathyroid Hormone during Mandibular Distraction Osteogenesis. Plastic and Reconstructive Surgery 137:2, pages 347e-354e.
Crossref
Christian Santa Maria, Zhiqiang Cheng, Alfred Li, Jiali Wang, Dolores Shoback, Chia-Ling Tu & Wenhan Chang. (2016) Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Seminars in Cell & Developmental Biology 49, pages 11-23.
Crossref
Shuangxin Liu, Weiping Zhu, Sijia Li, Tongxia Cui, Zhonghe Li, Bin Zhang, Zhuo Li, Jianxiong Wu, Xinling Liang, Zheng Lin & Wei Shi. (2015) The Effect of Bovine Parathyroid Hormone Withdrawal on MC3T3-E1 Cell Proliferation and Phosphorus Metabolism. PLOS ONE 10:3, pages e0120402.
Crossref
Leila Revollo, Jacqueline Kading, Sung Yeop Jeong, Jiemin Li, Valerie Salazar, Gabriel Mbalaviele & Roberto Civitelli. (2015) N-cadherin Restrains PTH Activation of Lrp6/β-catenin Signaling and Osteoanabolic Action. Journal of Bone and Mineral Research 30:2, pages 274-285.
Crossref
Thomas Mabey & Sittisak Honsawek. (2015) Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives. International Journal of Endocrinology 2015, pages 1-14.
Crossref
Leila Revollo & Roberto Civitelli. 2015. The Parathyroids. The Parathyroids 119 126 .
Mahalakshmi Honasoge, Ajay D. Rao & Sudhaker D. Rao. (2014) Sclerostin. Current Opinion in Endocrinology, Diabetes & Obesity 21:6, pages 437-446.
Crossref
Haagen D. Klaus. (2014) Frontiers in the bioarchaeology of stress and disease: Cross-disciplinary perspectives from pathophysiology, human biology, and epidemiology. American Journal of Physical Anthropology 155:2, pages 294-308.
Crossref
Jens Bay Vegger, Esben Sommer Nielsen, Annemarie Brüel & Jesper Skovhus Thomsen. (2014) Additive effect of PTH (1–34) and zoledronate in the prevention of disuse osteopenia in rats. Bone 66, pages 287-295.
Crossref
Shi-kun Yang, Li Xiao, Pan-ai Song, Xiaoxuan Xu, Fu-you Liu & Lin Sun. (2013) Effect of l-carnitine therapy on patients in maintenance hemodialysis: a systematic review and meta-analysis. Journal of Nephrology 27:3, pages 317-329.
Crossref
U. C. Bang, L. Hyldstrup & J. E. B. Jensen. (2013) The impact of recombinant parathyroid hormone on malignancies and mortality: 7 years of experience based on nationwide Danish registers. Osteoporosis International 25:2, pages 639-644.
Crossref
Eric S. Orwoll & Elizabeth Martin. 2014. Osteogenesis Imperfecta. Osteogenesis Imperfecta 519 525 .
Beata Chertok, Matthew J. Webber, Marc D. Succi & Robert Langer. (2013) Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies. Molecular Pharmaceutics 10:10, pages 3531-3543.
Crossref
Fan Li, Guifeng Li, Haikun Hu, Renkai Liu, Jianwei Chen & Shujuan Zou. (2013) Effect of parathyroid hormone on experimental tooth movement in rats. American Journal of Orthodontics and Dentofacial Orthopedics 144:4, pages 523-532.
Crossref
Christopher O. Audu, Jared C. Cochran, Maria Pellegrini & Dale F. Mierke. (2013) Recombinant production of TEV cleaved human parathyroid hormone. Journal of Peptide Science 19:8, pages 504-510.
Crossref
Jonathon Power, Paula Hernandez, John Wardale & Frances M. D. Henson. (2014) Alterations in sclerostin protein in lesions of equine osteochondrosis. Veterinary Record Open 1:1.
Crossref
Joseph P. Bidwell, Marta B. Alvarez, Mark HoodJrJr & Paul Childress. (2013) Functional Impairment of Bone Formation in the Pathogenesis of Osteoporosis: The Bone Marrow Regenerative Competence. Current Osteoporosis Reports 11:2, pages 117-125.
Crossref
Johannes D. VeldhuisPeter Y. Liu, Paul Y. TakahashiDaniel M. Keenan. (2012) Dynamic testosterone responses to near-physiological LH pulses are determined by the time pattern of prior intravenous LH infusion. American Journal of Physiology-Endocrinology and Metabolism 303:6, pages E720-E728.
Crossref
Kazuhiro Aoki, Neil Alles, Niroshani Soysa & Keiichi Ohya. (2012) Peptide-based delivery to bone. Advanced Drug Delivery Reviews 64:12, pages 1220-1238.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.