24
Views
81
CrossRef citations to date
0
Altmetric
Original Article

Restoration of Defective Oxygen-transport Function of Stored Red Blood Cells by Addition of Inosine

, , &
Pages 245-248 | Received 16 Dec 1967, Accepted 04 Mar 1968, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Fabio Scopesi, Silvana Canini, Cesare Arioni, Massimo Mazzella, Diego Gazzolo, Pasquale B. Lantieri, Wanda Bonacci & Giovanni Serra. (2006) Lack of effect of dietary nucleotide supplementation on erythrocyte 2,3-diphosphoglycerate concentration. A study on preterm neonates. The Journal of Maternal-Fetal & Neonatal Medicine 19:6, pages 343-346.
Read now
C. D. R. Dunn, D. J. Boden & L. D. Wallace. (1983) Is the stability of the oxyhaemoglobin dissociation curve in stored blood a function of the way the cells ‘pack’?. Scandinavian Journal of Clinical and Laboratory Investigation 43:2, pages 179-183.
Read now
C Robert Valeri & Tibor J. Greenwalt. (1982) Use of Rejuvenation Solutions in Blood Preservation. CRC Critical Reviews in Clinical Laboratory Sciences 17:4, pages 299-374.
Read now
Richard Juel & John O. Milam. (1979) 2,3-Diphosphoglycerate: Its Role in Health and Disease. CRC Critical Reviews in Clinical Laboratory Sciences 10:2, pages 113-146.
Read now
Paul R. Sohmer, R. Ben Dawson & Charles Huggins. (1979) The Significance of 2, 3–DPG in Red Blood Cell Transfusions. CRC Critical Reviews in Clinical Laboratory Sciences 11:2, pages 107-174.
Read now
G. Arturson & M. Westman. (1975) Survival of Rats Subjected to Acute Anemia at Different Levels of Erythrocyte 2, 3-Diphosphoglycerate. Scandinavian Journal of Clinical and Laboratory Investigation 35:8, pages 745-751.
Read now
C.-H. De Verdier & M. Westman. (1973) Intravenous Infusion of Inosine in Man: Effect on Erythrocyte 2,3-Diphosphoglycerate Concentration and on Blood Oxygen Affinity. Scandinavian Journal of Clinical and Laboratory Investigation 32:3, pages 205-210.
Read now
C. Robert Valeri & Tibor J. Greenwalt. (1970) Recent Advances in Techniques for Freezing Red Cells. CRC Critical Reviews in Clinical Laboratory Sciences 1:3, pages 381-425.
Read now
Carl-Henric de Verdier, Lars Garby, Magnus Hjelm, Poul Astrup & Mikael Rörth. (1970) The Erythrocyte as a Vehicle for Oxygen with Self-regulating Adjustment of Unloading. Scandinavian Journal of Clinical and Laboratory Investigation 26:3, pages 193-198.
Read now
G. Duc & K. Engel. (1969) Effect of 2,3-DPG Concentration on Hemoglobin-Oxygen Affinity of Whole Blood. Scandinavian Journal of Clinical and Laboratory Investigation 24:4, pages 405-412.
Read now
. (1968) Displacements of the Oxyhemoglobin Dissociation Curve. Scandinavian Journal of Clinical and Laboratory Investigation 22:3, pages 171-176.
Read now

Articles from other publishers (69)

Stevan P. Tofovic. (2023) Purine nucleoside phosphorylase: A new pharmacological target in sickle cell disease and hemolytic vasculopathy. Medical Hypotheses 173, pages 111045.
Crossref
F. Scopesi, C.M. Verkeste, D. Paola, D. Gazzolo, M.A. Pronzato, P.L. Bruschettini & U.M. Marinari. (1999) Dietary Nucleotide Supplementation Raises Erythrocyte 2,3-Diphosphoglycerate Concentration in Neonatal Rats. The Journal of Nutrition 129:3, pages 662-665.
Crossref
RAYMOND D. STARLING, TODD A. TRAPPE, KEVIN R. SHORT, MELINDA SHEFFIELD-MOORE, ALISON C. JOZSI, WILLIAM J. FINK & DAVID L. COSTILL. (1996) Effect of inosine supplementation on aerobic and anaerobic cycling performance. Medicine &amp Science in Sports &amp Exercise 28:9, pages 1193-1198.
Crossref
CHRIS ROSENBLOOMPhD, RDPhD, RD, MINDY MILLARD-STAFFORDPhDPhD & JIM LATHROPMEdMEd. (1992) Contemporary ergogenic aids used by strength/power athletes. Journal of the American Dietetic Association 92:10, pages 1264-1266.
Crossref
O. Åkerblom. 1990. Cryopreservation and low temperature biology in blood transfusion. Cryopreservation and low temperature biology in blood transfusion 95 104 .
Harold T. Meryman. (1989) Frozen Red Cells. Transfusion Medicine Reviews 3:2, pages 121-127.
Crossref
Karl-Georg von Boroviczény, Richard Merten & Utz Peter Merten. 1987. Qualitätssicherung. Qualitätssicherung 975 1060 .
Miriam B. Dahlke. (1984) Red Blood Cell Transfusion Therapy. Medical Clinics of North America 68:3, pages 639-656.
Crossref
N. Duedari & P. Mannoni. 1983. Care of the Critically Ill Patient. Care of the Critically Ill Patient 557 567 .
Paul R. Sohmer & Rhonda L. Scott. (1982) Massive Transfusion. Clinics in Laboratory Medicine 2:1, pages 21-34.
Crossref
Nobuji Maeda, Kazunori Kon, Misuzu Sekiya & Takeshi Shiga. (2008) Functional Restoration of ACD‐Blood by Pyridoxal 5′‐Phosphate. British Journal of Haematology 45:3, pages 467-480.
Crossref
N. Maeda, K. Kon, M. Sekiya & T. Shiga. (1979) Restoration of the poor oxygen transport function of ACD-stored blood by pyridoxal 5′-phosphate. Experientia 35:9, pages 1245-1246.
Crossref
Shigeru Sasakawa, Kenji Honda, Masaki Miyamoto & Eiichi Tokunaga. (1978) Change of Oxygen Affinity of Hemoglobin in Different Conditions of Blood Preservation. Vox Sanguinis 34:3, pages 164-170.
Crossref
L. Zolla, Carmela Ioppolo, G. Amiconi, A. Benaglia & E. Antonini. (1977) Changes in rate of methemoglobin reduction and oxygen affinity of erythrocytes incubated with inosine, pyruvate and phosphate. Experientia 33:11, pages 1524-1526.
Crossref
R. B. Dawson. (2003) Hemoglobin Function in Stored Blood: XIX. Inosine Maintenance of 2,3‐DPG for 35 Days in a CPD‐Adenine Preservative. Transfusion 17:5, pages 525-528.
Crossref
ROSEMARY MACDONALD. (2007) Red cell 2,3‐diphosphoglycerate and oxygen affinity. Anaesthesia 32:6, pages 544-553.
Crossref
R. B. Dawson. (2003) Blood storage XXIII: 2,3‐DPG maintenance for six weeks in a CPD‐adenine‐ inosine preservative with and without methylene blue. Transfusion 17:3, pages 238-241.
Crossref
N. Meyerstein, D. Mazor & A. Dvilansky. (2003) Changes in agglomeration of human red blood cells in liquid storage in CPD media. Transfusion 17:2, pages 115-122.
Crossref
Stanley GiannelliJr.Jr., J. Patrick McKenna, Joseph M. Bordiuk, Leonard D. Miller & Carl R. Jerome. (1976) Prevention of Increased Hemoglobin-Oxygen Affinity in Open-Heart Operations with Inosine-Phosphate-Pyruvate Solution. The Annals of Thoracic Surgery 21:5, pages 386-396.
Crossref
T. Vo Hong & B. Wuilleret. (2009) Effects of Rejuvenation of Blood on 2,3‐Diphosphoglycerate and Adenosine triphosphate and Mechanical Resistance of Red Blood Cells. Vox Sanguinis 29:4, pages 306-310.
Crossref
Olof Åkerblom & Anders Kreuger. (2009) Studies on Citrate‐Phosphate‐Dextrose (CPD) Blood Supplemented with Adenine. Vox Sanguinis 29:2, pages 90-100.
Crossref
Anders Kreuger, Olof Åkerblom & Claes F. Högman. (2009) A Clinical Evaluation of Citrate‐Phosphate‐Dextrose‐Adenine Blood. Vox Sanguinis 29:2, pages 81-89.
Crossref
Rita McConn. (1975) The Oxyhemoglobin Dissociation Curve in Acute Disease. Surgical Clinics of North America 55:3, pages 627-658.
Crossref
Christian Petrich, Ulrich Göbel & Ulrich Dolvos. (1975) Der Einfluß von Ribose auf die 2,3-Diphosphoglycerat-Konzentration menschlicher Erythrozyten. Blut Zeitschrift für die Gesamte Blutforschung 30:3, pages 175-182.
Crossref
Mary Lewis, Godfrey C. Pinder & Armand A. Lefemine. (1975) The Use of Saline-Washed Frozen Red Cells for Extracorporeal Bypass. The Annals of Thoracic Surgery 19:2, pages 153-157.
Crossref
Chr. Petrich, U. Göbel & U. Delvos. (1975) Effect of Bilirubin on Stored Red Blood Cells. Clinical Chemistry and Laboratory Medicine 13:10.
Crossref
C.R. VALERI. 1975. The Red Blood Cell. The Red Blood Cell 1303 1338 .
Henry M. ThomasIIIIII, Stephen S. Lefrak, Richard S. Irwin, Harry W. FrittsJr.Jr. & Peter R.B. Caldwell. (1974) The oxyhemoglobin dissociation curve in health and disease. The American Journal of Medicine 57:3, pages 331-348.
Crossref
Bronislaw Zachara & Jan Lewandowski. (1974) Isolation and identification of inosine triphosphate from human erythrocytes. Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 353:2, pages 253-259.
Crossref
D.H. Buchholz. (1974) Blood transfusion: Merits of component therapy. The Journal of Pediatrics 84:1, pages 1-15.
Crossref
C.R. VALERI. 1974. The Red Blood Cell. The Red Blood Cell 511 574 .
J.D. Torrance. (1974) Diphosphoglycerate mutase assay: The effect of pyruvate, lactate dehydrogenase and thyroid hormone on the assay. Clinica Chimica Acta 50:1, pages 103-109.
Crossref
Christian Petrich & Ulrich G�bel. (1974) On the regulation of 2,3-diphosphoglycerate concentration in the erythrocytes of newborns with transitory hyperbilirubinemia. Zeitschrift f�r Kinderheilkunde 117:2, pages 121-126.
Crossref
A. J. Bellingham & A. J. Grimes. (2008) RED CELL 2,3‐DIPHOSPHOGLYCERATE. British Journal of Haematology 25:5, pages 555-562.
Crossref
P. L. La Celle, F. H. Kirkpatrick, M. P. Udkow & B. Arkin. 1973. Red Cell Shape. Red Cell Shape 69 78 .
C. R. Valeri & C. G. Zaroulis. (1972) Rejuvenation and Freezing of Outdated Stored Human Red Cells. New England Journal of Medicine 287:26, pages 1307-1313.
Crossref
K.G.M.M Alberti, PaulineM Emerson, J.H Darley & T.D.R Hockaday. (1972) 2,3-DIPHOSPHOGLYCERATE AND TISSUE OXYGENATION IN UNCONTROLLED DIABETES MELLITUS. The Lancet 300:7774, pages 391-395.
Crossref
J. Luque, M. Pinilla, M.E. Ventura & A. Santos-Ruiz. (1972) Factors affecting the concentration of 2,3-diphosphoglycerate in erythrocytes. FEBS Letters 23:1, pages 31-33.
Crossref
C.-H. de Verdier & L. Garby. (1972) 2,3-Diphosphoglycerate and respiratory function of hemoglobin. Biochimie 54:5-6, pages 613-617.
Crossref
R. Ben Dawson & Walter F. Kocholaty. 1972. Hemoglobin and Red Cell Structure and Function. Hemoglobin and Red Cell Structure and Function 495 509 .
C. Robert Valeri & Charles G. Zaroulis. 1972. Hemoglobin and Red Cell Structure and Function. Hemoglobin and Red Cell Structure and Function 457 477 .
C. R. Valeri & C. J. Kopriva. 1972. The Fundamental Mechanisms of Shock. The Fundamental Mechanisms of Shock 177 193 .
Claes F. Högman. (1971) OXYGEN AFFINITY OF STORED BLOOD. Acta Anaesthesiologica Scandinavica 15, pages 53-61.
Crossref
M. M. Strumia & P. V. Strumia. (1971) Transfusion of Long Stored Whole Blood or Washed Red Blood Cells Incubated with Adenine and Inosine. Transfusion 11:5, pages 258-265.
Crossref
Nicholas C. Bethlenfalvay. (1971) The effect of inosine on the redistribution of CO between human erythrocytes. Blut Zeitschrift für die Gesamte Blutforschung 23:3, pages 163-166.
Crossref
R. K. Chillar, P. Slawskyand & Jane F. Desforges. (2008) Red Cell 2,3‐Diphosphoglycerate and Adenosine Triphosphate in Patients with Shock*. British Journal of Haematology 21:2, pages 183-188.
Crossref
J. Duhm, B. Deuticke & E. Gerlach. (1971) Complete Restoration of Oxygen Transport Function and 2,3-Diphosphoglycerate Concentration in Stored Blood. Transfusion 11:3, pages 147-151.
Crossref
L. Wood & E. Beutler. (1971) Storage of Erythrocytes in Artificial Media. Transfusion 11:3, pages 123-133.
Crossref
Raymond E. Vanderlinde & Patricia Kowalski. (1971) The clinical biochemistry of phosphorus. Clinical Biochemistry 4:1-6, pages 76-88.
Crossref
Susumu Tomita & Austen Riggs. (1971) Studies of the Interaction of 2,3-Diphosphoglycerate and Carbon Dioxide with Hemoglobins from Mouse, Man, and Elephant. Journal of Biological Chemistry 246:3, pages 547-554.
Crossref
C. Robert Valeri. (1971) Viability and Function of Preserved Red Cells. New England Journal of Medicine 284:2, pages 81-88.
Crossref
B. Deuticke, J. Duhm & R. Dierkesmann. (1971) Maximal elevation of 2,3-diphosphoglycerate concentrations in human erythrocytes: Influence on glycolytic metabolism and intracellular pH. Pfl�gers Archiv European Journal of Physiology 326:1, pages 15-34.
Crossref
Frank A. Oski & Maria Delivoria-Papadopoulos. (1970) The red cell, 2,3-diphosphoglycerate, and tissue oxygen release. The Journal of Pediatrics 77:6, pages 941-956.
Crossref
R. B. DawsonJr.Jr., W. F. Kocholaty & J. L. Gray. (1970) Hemoglobin Function and 2,3-DPG Levels of Blood Stored at 4 C in ACD and CPD pH Effect. Transfusion 10:6, pages 299-304.
Crossref
JOHN G. GIBSONIIII, TIBOR J. GREENWALT, CLAES F. HÖGMANN, S. RAPOPORT, S. SEIDL, CHARLES E. SHIELDS, C. ROBERT VALERI & ERNEST BEUTLER. (1970) International Forum. Vox Sanguinis 19:5-6, pages 546-561.
Crossref
C. R. Valeri, J. A. Bougas, L. Talarico, C. P. Emerson, T. Didimizio & L. Pivacek. (1970) Behavior of Previously Frozen Erythrocytes Used during Open-heart Surgery. Transfusion 10:5, pages 238-246.
Crossref
John D. Torrance & Grant R. Bartlett. (1970) Altitude hypoxia and erythrocyte phosphates. Biochimica et Biophysica Acta (BBA) - General Subjects 215:2, pages 409-411.
Crossref
I. O. Szymanski, H. M. Dean, C. R. Valeri, J. A. Bougas & J. F. Desforges. (2009) Measurement of Erythrocyte Survival during Open‐heart Surgery. Transfusion 10:4, pages 163-170.
Crossref
Louis M. Sherwood, Edith E. Parris, H. Franklin Bunn & James H. Jandl. (1970) Control of Hemoglobin Function within the Red Cell. New England Journal of Medicine 282:25, pages 1414-1421.
Crossref
R. B. DawsonJr.Jr. & T. J. Ellis. (1970) Hemoglobin Function of Blood Stored at 4 C in ACD and CPD with Adenine and Inosine. Transfusion 10:3, pages 113-120.
Crossref
Frank A. Oski, Arlan J. Gottlieb & Leonard Miller. (1970) The Influences of Heredity and Environment on the Red Cells’ Function of Oxygen Transport. Medical Clinics of North America 54:3, pages 731-743.
Crossref
S. Grisolia, J. Carreras, D. Diederich & S. Charache. 1970. Red Cell Metabolism and Function. Red Cell Metabolism and Function 39 55 .
R. Ben DawsonJr.Jr.. 1970. Red Cell Metabolism and Function. Red Cell Metabolism and Function 305 317 .
C. Robert Valeri & Normand L. Fortier. 1970. Red Cell Metabolism and Function. Red Cell Metabolism and Function 289 303 .
Lars Garby & Carl-Henric de Verdier. 1970. Red Cell Metabolism and Function. Red Cell Metabolism and Function 3 7 .
. (1969) A Shifting Curve. The Lancet 294:7624, pages 784-786.
Crossref
L. Garby, C.-H. Verdier & G. Gerber. (2005) Binding of 2,3-Diphosphoglycerate and Adenosine Triphosphate to Human Haemoglobin A. European Journal of Biochemistry 10:1, pages 110-115.
Crossref
T. H. J. Huisman, E. M. Boyd, J. Kitchens, S. Mayson & W. L. Shepeard. (2009) Oxygen Equilibria and Biochemical Changes of Whole Blood Stored in Different Preservation Media. Transfusion 9:4, pages 180-190.
Crossref
REINHOLD BENESCH & RUTH E. BENESCH. (1969) Intracellular Organic Phosphates as Regulators of Oxygen Release by Haemoglobin. Nature 221:5181, pages 618-622.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.