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Scandinavian Journal of Gastroenterology Volume 25, 1990 - Issue 5
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Original Article

Effects of Endogenous and Exogenous Cholecystokinin and of Infusion with the Cholecystokinin Antagonist L-364,718 on Pancreatic and Gastrointestinal Growth

J. Axelson Depts. of Surgery, Pharmacology, and Medical Cell Research, University of Lund, Lund, Sweden; Dept. of Surgery, University of Linköping, Linkoping, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
,
R. Hakanson Depts. of Surgery, Pharmacology, and Medical Cell Research, University of Lund, Lund, Sweden; Dept. of Surgery, University of Linköping, Linkoping, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
,
I. Ihse Depts. of Surgery, Pharmacology, and Medical Cell Research, University of Lund, Lund, Sweden; Dept. of Surgery, University of Linköping, Linkoping, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
,
I. Lilja Depts. of Surgery, Pharmacology, and Medical Cell Research, University of Lund, Lund, Sweden; Dept. of Surgery, University of Linköping, Linkoping, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
,
J. F. Rehfeld Depts. of Surgery, Pharmacology, and Medical Cell Research, University of Lund, Lund, Sweden; Dept. of Surgery, University of Linköping, Linkoping, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
&
F. Sundler Depts. of Surgery, Pharmacology, and Medical Cell Research, University of Lund, Lund, Sweden; Dept. of Surgery, University of Linköping, Linkoping, Sweden; Dept. of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Pages 471-480 | Received 25 Apr 1989, Accepted 30 Oct 1989, Published online: 08 Jul 2009

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B. G. Fan, J. Axelson, B. Sternby, J. Rehfeld, I. Ihse & M. Ekelund. (1997) Total Parenteral Nutrition Affects the Trophic Effect of Cholecystokinin on the Exocrine Pancreas. Scandinavian Journal of Gastroenterology 32:4, pages 380-386.
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D. Chen, A.-G. Nylander, P. Norlé & R. Häkanson. (1996) Gastrin Does Not Stimulate Growth of the Rat Pancreas. Scandinavian Journal of Gastroenterology 31:4, pages 404-410.
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D. Chen, X.-Q. Ding, J. F. Rehfeld & R. Håkanson. (1994) Endogenous Gastrin and Cholecystokinin Do Not Promote Growth of Rat Liver. Scandinavian Journal of Gastroenterology 29:8, pages 688-692.
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D. Chen, A.-G. Nylander, J. F. Rehfeld, F. Sundler & R. Håkanson. (1993) Hypercholecystokininemia Produced by Pancreaticobiliary Diversion Causes Gastrin-Like Effects on Enterochromaffin-Like Cells in the Stomach of Rats Subjected to Portacaval Shunting or Antrectomy. Scandinavian Journal of Gastroenterology 28:11, pages 988-992.
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A. G. Nylander, D. Chen, J. F. Rehfeld & R. Hakånson. (1993) Portacaval Shunt Increases the Trophic Effect of Cholecystokinin on the Rat Pancreas. Scandinavian Journal of Gastroenterology 28:2, pages 145-148.
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A.-G. Nylander, R. Håkanson, D. Chen, I. Lilja, J. Axelson, I. Ihse, J. F. Rehfeld & F. Sundler. (1993) Enterochromaffin-like Cells in Rat Stomach Respond to Short-Term Infusion of High Doses of Cholecystokinin But Not to Long-Term, Sustained, Moderate HyperCCKemia Caused by Continuous Cholecystokinin Infusion or Pancreaticobiliary Diversion. Scandinavian Journal of Gastroenterology 28:1, pages 73-79.
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D. Chen, K. Andersson, J.-L. Iovanna, J.-C. Dagorn & R. Håkanson. (1993) Effects of Hypercholecystokininemia Produced by Pancreaticobiliary Diversion on Pancreatic Growth and Enzyme mRNA Levels in Starved Rats. Scandinavian Journal of Gastroenterology 28:4, pages 311-314.
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S. Skullman, M. Chu, I. Ihse & J. Larsson. (1992) Effect of Pancreaticobiliary Diversion on Liver Regeneration. Scandinavian Journal of Gastroenterology 27:2, pages 85-88.
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Jan Axelson, Ingemar Ihse & Rolf Hakanson. (1992) Pancreatic Cancer: The Role of Cholecystokinin?. Scandinavian Journal of Gastroenterology 27:12, pages 993-998.
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A.-G. Nylander, D. Chen, I. Ihse, J. F Rehfeld & R Hakanson. (1992) Pancreatic Atrophy in Rats Produced by the Cholecystokinin-A Receptor Antagonist Devazepide. Scandinavian Journal of Gastroenterology 27:9, pages 743-747.
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D. Chen, A. G. Nylander, J. F. Rehfeld, J. Axelson, I. Ihse & R. Håkanson. (1992) Does Vagotomy Affect the Growth of the Pancreas in the Rat?. Scandinavian Journal of Gastroenterology 27:7, pages 606-608.
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T. Gasslander, M. Chu, S. Smeds & I. Ihse. (1991) Proliferative Response of Different Exocrine Pancreatic Cells after Surgical Pancreaticobiliary Diversion in the Rat. Scandinavian Journal of Gastroenterology 26:4, pages 399-404.
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T. Gasslander, J. Axelson, R. Håkanson, I. Ihse, I. Lilja & J. F. Rehfeld. (1990) Cholecystokinin Is Responsible for Growth of the Pancreas after Pancreaticobiliary Diversion in Rats. Scandinavian Journal of Gastroenterology 25:10, pages 1060-1065.
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Articles from other publishers (37)

X‐M. Wu, Y‐W. Liao, K‐Q. Ji, G‐F. Li & B. Zang. (2011) The trophic effect of cholecystokinin on the pancreas declines in rats on total parenteral nutrition. Journal of Animal Physiology and Animal Nutrition 96:2, pages 214-219.
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J Morisset. (2008) Hormonal control of pancreatic growth during fetal, neonatal and adult life. Advances in Medical Sciences 53:2.
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Nielsen Q Fernandez-Becker & Alan C Moss. (2008) Improving Delivery of Aminosalicylates in Ulcerative Colitis. Drugs 68:8, pages 1089-1103.
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Bo-Guang Fan. (2008) Effects of Parenteral Nutrition on the Exocrine Pancreas in Response to Cholecystokinin. Journal of Parenteral and Enteral Nutrition 32:1, pages 57-62.
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A N Kingsnorth, L J Formela, D Chen & J F Rehfeld. (1994) Plasma gastrin and cholecystokinin responses after pylorus-preserving pancreatoduodenectomy and defunctioned Roux loop pancreaticojejunostomy. British Journal of Surgery 81:9, pages 1356-1359.
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Markus Schweiger, Martin Steffl & Werner M. Amselgruber. (2005) Determination of target cells for Cholecystokinin in the porcine pancreas. Annals of Anatomy - Anatomischer Anzeiger 187:3, pages 209-214.
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Haruaki Kageyama, Tetsuro Kita, Shigeru Horie, Fumiko Takenoya, Hisayuki Funahashi, Sachi Kato, Masami Hirayama, Eun Young Lee, Junko Sakurai, Shuji Inoue & Seiji Shioda. (2005) Immunohistochemical analysis of cholecystokinin A receptor distribution in the rat pancreas. Regulatory Peptides 126:1-2, pages 137-143.
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Lena M. Trulsson, Thomas Gasslander & Joar Svanvik. (2004) Cholecystokinin-8-Induced Hypoplasia of the Rat Pancreas: Influence of Nitric Oxide on Cell Proliferation and Programmed Cell Death. Pharmacology and Toxicology 95:4, pages 183-190.
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Duan Chen, Chun-Mei Zhao, Rolf Håkanson, Linda C. Samuelson, Jens F. Rehfeld & Lennart Friis-Hansen. (2004) Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice. Gastroenterology 126:2, pages 476-487.
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Emmanuelle Kuntz, Michel Pinget & Christiane Damgé. (2002) Effects of cholecystokinin octapeptide on the exocrine pancreas in a new rat model of type 2 diabetes. European Journal of Pharmacology 448:2-3, pages 253-261.
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Lena M. Trulsson, Joar Svanvik, Johan Permert & Thomas Gasslander. (2001) Cholecystokinin octapeptide induces both proliferation and apoptosis in the rat pancreas. Regulatory Peptides 98:1-2, pages 41-48.
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M. Schweiger, M. H. Erhard & W. M. Amselgruber. (2008) Cell‐specific Localization of the Cholecystokinin A Receptor in the Porcine Pancreas . Anatomia, Histologia, Embryologia 29:6, pages 357-361.
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Bodil Ohlsson, Toru Yusa, Jens F Rehfeld, Ingmar Lundquist, Ingemar Ihse & Jan Axelson. (2000) Effects of Intraluminal Trypsin and Bile on the Exocrine and Endocrine Pancreas After Pancreaticobiliary Diversion and Biliodigestive Shunt. Pancreas 20:2, pages 170-176.
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M Biernat, R Zabielski, P Sysa, B Sosak-Swiderska, I Le Huërou-Luron & P Guilloteau. (1999) Small intestinal and pancreatic microstructures are modified by an intraduodenal CCK-A receptor antagonist administration in neonatal calves. Regulatory Peptides 85:2-3, pages 77-85.
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Sreekant Murthy & Anne Flanigan. 1999. In Vivo Models of Inflammation. In Vivo Models of Inflammation 205 236 .
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Craig D. Logsdon. 1999. Gastrointestinal Endocrinology. Gastrointestinal Endocrinology 393 422 .
Bodil Ohlsson, Karin Borg, Jens F. Rehfeld, Ingemar Ihse & Jan Axelson. (1998) The effect of intermittent injections of CCK-8S and the CCK-A receptor antagonist devazepide on cell proliferation in exocrine rat pancreas. International journal of pancreatology 24:3, pages 211-218.
Crossref
Gábor Varga, Krisztina Kisfalvi, Iva Pelosini, Massimo D'Amato & Carmelo Scarpignato. (2009) Different actions of CCK on pancreatic and gastric growth in the rat: effect of CCK A receptor blockade . British Journal of Pharmacology 124:3, pages 435-440.
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K. Shimizu, Y. Kato, K. Shiratori, Y. Ding, Y. Song, R. Furlanetto, T.-M. Chang, S. Watanabe, N. Hayashi, M. Kobayashi & W. Y. Chey. (1998) Evidence for the Existence of CCK-Producing Cells in Rat Pancreatic Islets*. Endocrinology 139:1, pages 389-396.
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Issei Imoto, Mitsuyoshi Yamamoto, Dong Mei Jia & Makoto Otsuki. (1997) Effect of chronic oral administration of the CCK receptor antagonist loxiglumide on exocrine and endocrine pancreas in normal rats. International journal of pancreatology 22:3, pages 177-185.
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G Varga, K Kisfalvi, M D'Amato & C Scarpignato. (1997) Effect of a new CCK-A receptor antagonist, dexloxiglumide, on the exocrine pancreas in the rat. Journal of Physiology-Paris 91:3-5, pages 257-264.
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Anna‐Greta Nylander, Duan Chen, Xi‐Qin Ding, Per Norlén & Rolf Håkanson. (2009) The Trophic Response of Rat Pancreas to Sulfated Cholecystokinin‐8 is Dose‐ and Time‐Dependent and Not Affected by Vagotomy or Atropine. Pharmacology & Toxicology 80:3, pages 142-146.
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Jan Axelson, Bo Guang Fan, Bodil Ohlsson, Jens Rehfeld, Mats Ekelund & Ingemar Ihse. (1996) The changes in the rat parotid glands following total parenteral nutrition and pancreatico-biliary diversion are not mediated by cholecystokinin. International journal of pancreatology 20:2, pages 109-118.
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B.L Mania-Farnell, I.W Botros & T.P Davis. (1995) Modulation of CCK mRNA in cell lines in response to isoproterenol and retinoic acid. Neuropeptides 29:4, pages 221-227.
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Bodil Ohlsson, Jan Axelson, Berit Sternby, Jens F. Rehfeld & Ingemar Ihse. (1995) Time-course of the pancreatic changes following long-term stimulation or inhibition of the CCK-A receptor. International journal of pancreatology 18:1, pages 59-66.
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GRAHAM S. BALDWIN. (2008) The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth. Journal of Gastroenterology and Hepatology 10:2, pages 215-232.
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Stephen P. Povoski, Weigong Zhou, Daniel S. Longnecker, Robert T. Jensen, Samuel A. Mantey & Richard H. BellJrJr. (1994) Stimulation of in vivo pancreatic growth in the rat is mediated specifically by way of cholecystokinin-A receptors. Gastroenterology 107:4, pages 1135-1146.
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Makoto Otsuki, Shigekazu Nakano & Issei Tachibana. (1994) Treatment with cholecystokinin receptor antagonist loxiglumide enhances insulin response to intravenous glucose stimulation in postpancreatitic rats. Regulatory Peptides 52:2, pages 85-95.
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Graham S. Baldwin & Robert H. Whitehead. (1994) 8 Gut hormones, growth and malignancy. Baillière's Clinical Endocrinology and Metabolism 8:1, pages 185-214.
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Ming Chu, Jens F. Rehfeld & Kurt Borch. (1993) Colonic mucosal proliferation after pancreaticobiliary diversion in the hamster. Digestive Diseases and Sciences 38:11, pages 1978-1984.
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Mark L. Silen & Jerry D. Gardner. (1993) Gastrointestinal peptides and cancer. Trends in Endocrinology & Metabolism 4:4, pages 131-135.
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Jens F. Rehfeld, Linda Bardram & Linda Hilsted. (1992) Ontogeny of procholecystokinin maturation in rat duodenum, jejunum, and ileum. Gastroenterology 103:2, pages 424-430.
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Christina HADJIIVANOVA, Marlène DUFRESNE, Sandrine POIROT, Patricia SOZZANI, Nicole VAYSSE, Luis MORODER & Daniel FOURMY. (2005) Pharmacological and biochemical characterization of cholecystokinin/gastrin receptors in developing rat pancreas. European Journal of Biochemistry 204:1, pages 273-279.
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