130
Views
138
CrossRef citations to date
0
Altmetric
Original Article

Glucagon-like Peptide 1 (7-36 hide) Secretion in Response to Luminal Sucrose from the Upper and Lower Gut: A Study Using α-Glucosidase Inhibition (Acarbose)

, , , &
Pages 892-896 | Received 17 Jul 1994, Accepted 22 Dec 1994, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Shinya Nishio, Mariko Abe & Hiroyuki Ito. (2015) Anagliptin in the treatment of type 2 diabetes: safety, efficacy, and patient acceptability. Diabetes, Metabolic Syndrome and Obesity 8, pages 163-171.
Read now
Sanjay Kalra. (2014) Incretin enhancement without hyperinsulinemia: α-glucosidase inhibitors. Expert Review of Endocrinology & Metabolism 9:5, pages 423-425.
Read now
Christoph Rosak & Gabriele Mertes. (2012) Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations. Diabetes, Metabolic Syndrome and Obesity 5, pages 357-367.
Read now
Markolf Hanefeld & Frank Schaper. (2008) Acarbose: oral antidiabetes drug with additional cardiovascular benefits. Expert Review of Cardiovascular Therapy 6:2, pages 153-163.
Read now
Jens Juul Holst. (1999) Treatment of Type 2 diabetes mellitus based on glucagon-like peptide-1. Expert Opinion on Investigational Drugs 8:9, pages 1409-1415.
Read now

Articles from other publishers (132)

Niels B. Dalsgaard, Lærke S. Gasbjerg, Mads M. Helsted, Laura S. Hansen, Nina L. Hansen, Kirsa Skov-Jeppesen, Bolette Hartmann, Jens J. Holst, Tina Vilsbøll & Filip K. Knop. (2023) Acarbose diminishes postprandial suppression of bone resorption in patients with type 2 diabetes. Bone 170, pages 116687.
Crossref
Tara Ranjbar, Jennifer L. O’Connor & Khosrow Kashfi. 2022. The Role of Nitric Oxide in Type 2 Diabetes. The Role of Nitric Oxide in Type 2 Diabetes 210 237 .
Anna Pii Hjørne, Ida Marie Modvig & Jens Juul Holst. (2022) The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion. Metabolites 12:5, pages 420.
Crossref
Cong Xie, Weikun Huang, Linda E Watson, Stijn Soenen, Richard L Young, Karen L Jones, Michael Horowitz, Christopher K Rayner & Tongzhi Wu. (2022) Plasma GLP-1 Response to Oral and Intraduodenal Nutrients in Health and Type 2 Diabetes—Impact on Gastric Emptying. The Journal of Clinical Endocrinology & Metabolism 107:4, pages e1643-e1652.
Crossref
Marion G. Priebe, Coby Eelderink & Roel J. Vonk. 2021. Whole Grains and Health. Whole Grains and Health 275 288 .
Tongzhi Wu, Christopher K Rayner, Karen L Jones, Cong Xie, Chinmay Marathe & Michael Horowitz. (2020) Role of intestinal glucose absorption in glucose tolerance. Current Opinion in Pharmacology 55, pages 116-124.
Crossref
L.K. Debarba, A. Mulka, J.B.M. Lima, O. Didyuk, P. Fakhoury, L. Koshko, A.A. Awada, K. Zhang, U. Klueh & M. Sadagurski. (2020) Acarbose protects from central and peripheral metabolic imbalance induced by benzene exposure. Brain, Behavior, and Immunity 89, pages 87-99.
Crossref
Cong Xie, Karen L. Jones, Christopher K. Rayner & Tongzhi Wu. (2020) Enteroendocrine Hormone Secretion and Metabolic Control: Importance of the Region of the Gut Stimulation. Pharmaceutics 12:9, pages 790.
Crossref
Changlin Li, Jian Kuang, Yishen Zhao, Hui Sun & Haixia Guan. (2020) Effect of type 2 diabetes and antihyperglycemic drug therapy on signs of tumor invasion in papillary thyroid cancer. Endocrine 69:1, pages 92-99.
Crossref
Ulf Holmbäck, Anders Forslund, Stefan Grudén, Göran Alderborn, Arvid Söderhäll, Per M. Hellström & Hans Lennernäs. (2020) Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity. Obesity Science & Practice 6:3, pages 313-323.
Crossref
Hung Pham, Laurence Trahair, Liza Phillips, Christopher Rayner, Michael Horowitz & Karen Jones. (2019) A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults. BMC Geriatrics 19:1.
Crossref
Byron J Smith, Richard A Miller, Aaron C Ericsson, David C Harrison, Randy Strong & Thomas M Schmidt. (2019) Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice. BMC Microbiology 19:1.
Crossref
T.D. Müller, B. Finan, S.R. Bloom, D. D'Alessio, D.J. Drucker, P.R. Flatt, A. Fritsche, F. Gribble, H.J. Grill, J.F. Habener, J.J. Holst, W. Langhans, J.J. Meier, M.A. Nauck, D. Perez-Tilve, A. Pocai, F. Reimann, D.A. Sandoval, T.W. Schwartz, R.J. Seeley, K. Stemmer, M. Tang-Christensen, S.C. Woods, R.D. DiMarchi & M.H. Tschöp. (2019) Glucagon-like peptide 1 (GLP-1). Molecular Metabolism 30, pages 72-130.
Crossref
Jens J. Holst, Nicolai J. Wewer Albrechtsen, Mette M. Rosenkilde & Carolyn F. Deacon. 2011. Comprehensive Physiology. Comprehensive Physiology 1339 1381 .
Teresa Salvatore, Riccardo Nevola, Pia Clara Pafundi, Lucio Monaco, Carmen Ricozzi, Simona Imbriani, Luca Rinaldi & Ferdinando Carlo Sasso. (2019) Incretin Hormones: The Link between Glycemic Index and Cardiometabolic Diseases. Nutrients 11:8, pages 1878.
Crossref
Christoffer Martinussen, Kristine Nyvold Bojsen-Møller, Carsten Dirksen, Maria Saur Svane, Viggo Bjerregaard Kristiansen, Bolette Hartmann, Jens Juul Holst & Sten Madsbad. (2019) Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion. The Journal of Clinical Endocrinology & Metabolism 104:8, pages 3233-3244.
Crossref
Pham, Phillips & Jones. (2019) Acute Effects of Nutritive and Non-Nutritive Sweeteners on Postprandial Blood Pressure. Nutrients 11:8, pages 1717.
Crossref
Soyeon Yoo, Eun-Jin YangGwanpyo Koh. (2019) Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus. Diabetes & Metabolism Journal 43:4, pages 495.
Crossref
Markolf Hanefeld & Gabriele Mertes. 2019. Encyclopedia of Endocrine Diseases. Encyclopedia of Endocrine Diseases 238 244 .
Se Hee Min, Jeong-Hwa Yoon, Seokyung Hahn & Young Min Cho. (2018) Efficacy and safety of combination therapy with an α-glucosidase inhibitor and a dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes mellitus: A systematic review with meta-analysis. Journal of Diabetes Investigation 9:4, pages 893-902.
Crossref
Timothy M. E. Davis, Hillary Mulder, Yuliya Lokhnygina, Pablo Aschner, Lee‐Ming Chuang, Carlos A. Raffo Grado, Eberhard Standl, Eric D. Peterson & Rury R. Holman. (2018) Effect of race on the glycaemic response to sitagliptin: Insights from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). Diabetes, Obesity and Metabolism 20:6, pages 1427-1434.
Crossref
Fiona M. Gribble, Claire L. Meek & Frank Reimann. (2018) Targeted intestinal delivery of incretin secretagogues—towards new diabetes and obesity therapies. Peptides 100, pages 68-74.
Crossref
Marion G. Priebe, Coby Eelderink, Renate E. Wachters-Hagedoorn & Roel J. Vonk. 2018. Starch in Food. Starch in Food 805 826 .
Yiming Zhao, Yongjian Wang, Hanyu Lou & Lizhen Shan. (2017) Alpha-glucosidase inhibitors and risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis. Oncotarget 8:46, pages 81027-81039.
Crossref
Na Wang, Jin‐Ping Zhang, Xiao‐Yan Xing, Zhao‐Jun Yang, Bo Zhang, Xin Wang & Wen‐Ying Yang. (2016) Associations between changes in glucagon‐like peptide‐1 and bodyweight reduction in patients receiving acarbose or metformin treatment. Journal of Diabetes 9:8, pages 728-737.
Crossref
Pleunie Hogenkamp. 2017. Flavor, Satiety and Food Intake. Flavor, Satiety and Food Intake 57 88 .
Andreas Pfützner, Filiz Demircik, Daniela Sachsenheimer, Jan Spatz, Anke H. Pfützner & Sanja Ramljak. (2016) Impact of Xylose on Glucose-Dehydrogenase-Based Blood Glucose Meters for Patient Self-Testing. Journal of Diabetes Science and Technology 11:3, pages 577-583.
Crossref
Coby Eelderink, Martijn W. J. Noort, Nesli Sozer, Martijn Koehorst, Jens J. Holst, Carolyn F. Deacon, Jens F. Rehfeld, Kaisa Poutanen, Roel J. Vonk, Lizette Oudhuis & Marion G. Priebe. (2016) Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men. European Journal of Nutrition 56:3, pages 1063-1076.
Crossref
Kenji Kanoshima, Mizue Matsuura, Megumi Kaai, Yumi Inoh, Kanji Ohkuma, Hiroshi Iida, Takashi Nonaka, Koji Fujita, Tomonori Ida, Akihiko Kusakabe, Atsushi Nakajima & Masahiko Inamori. (2017) The α-glucosidase inhibitor voglibose stimulates delayed gastric emptying in healthy subjects: a crossover study with a <sup>13</sup>C breath test. Journal of Clinical Biochemistry and Nutrition 60:3, pages 216-218.
Crossref
Sony S. Thazhath, Tongzhi Wu, Michelle J. Bound, Helen L. Checklin, Scott Standfield, Karen L. Jones, Michael Horowitz & Christopher K. Rayner. (2016) Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release, and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes: A randomised controlled trial. Nutrition 32:5, pages 553-559.
Crossref
W. A. Scherbaum. (2016) α-Glukosidase-Hemmer und Thiazolidindione (Glitazone)α-Glucosidase inhibitors and thiazolidinediones (glitazones). Der Diabetologe 12:3, pages 178-183.
Crossref
Meidjie AngMeidjie Ang. 2016. Metabolic Response of Slowly Absorbed Carbohydrates in Type 2 Diabetes Mellitus. Metabolic Response of Slowly Absorbed Carbohydrates in Type 2 Diabetes Mellitus 97 115 .
Hsin-Hua Chen, Der-Yuan Chen, Ya-Hsuan Chao, Yi-Ming Chen, Chao-Liang Wu, Kuo-Lung Lai, Ching-Heng Lin & Chi-Chen Lin. (2015) Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice. Scientific Reports 5:1.
Crossref
Roger D Gibb, Johnson W McRorieJr.Jr., Darrell A Russell, Vic Hasselblad & David A D’Alessio. (2015) Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus. The American Journal of Clinical Nutrition 102:6, pages 1604-1614.
Crossref
JINQUAN SHUANG, YING ZHANG, LIMEI MA, XUEMING TAN, JING HUANG, XIANG WANG, GUANYIN XIONG, ZHONGHUA JIANG, XIUHUA ZHANG, SHIQING DU, YONGSONG GU, XIANGYANG SHI & ZHINING FAN. (2015) Relief of diabetes by duodenal-jejunal bypass sleeve implantation in the high-fat diet and streptozotocin-induced diabetic rat model is associated with an increase in GLP-1 levels and the number of GLP-1-positive cells. Experimental and Therapeutic Medicine 10:4, pages 1355-1363.
Crossref
Atsuko Tamasawa, Kazuki Mochizuki, Natsuyo Hariya, Miyoko Saito, Hidenori Ishida, Satako Doguchi, Syoko Yanagiya & Takeshi Osonoi. (2015) Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients. European Journal of Pharmacology 762, pages 96-101.
Crossref
Kristina Blaslov, Tomislav Bulum, Karin Zibar & Lea Duvnjak. (2014) Relationship between metabolic syndrome and meal‐induced glucagon like peptide‐1 response in type 1 diabetic patients在1型糖尿病患者中代谢综合征与进餐诱导的胰高血糖素样肽‐1应答之间的关系. Journal of Diabetes 7:3, pages 340-346.
Crossref
Miyako Kishimoto & Mitsuhiko Noda. (2014) Additive Effects of Miglitol and Anagliptin on Insulin-Treated Type 2 Diabetes Mellitus: A Case Study. Clinical Drug Investigation 35:2, pages 141-147.
Crossref
Ivan Ivanovich Dedov, Ekaterina Anatol'evna Troshina, Ekaterina Vladimirovna Ershova & Yuriy Ivanovich Yashkov. (2015) Glucose metabolism and production of incretins in patients with obesity and type 2 diabetes mellitus after Biliopancreatic bypass surgery in the modification of Hess-Marceau the early stages of postoperative monitoring. Obesity and metabolism 12:1, pages 29-39.
Crossref
Mark F McCarty & James J DiNicolantonio. (2015) Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1. Open Heart 2:1, pages e000205.
Crossref
Tongzhi Wu, Christopher K. Rayner & Michael Horowitz. 2016. Metabolic Control. Metabolic Control 137 171 .
Meidjie Ang & Thomas Linn. (2014) Comparison of the effects of slowly and rapidly absorbed carbohydrates on postprandial glucose metabolism in type 2 diabetes mellitus patients: a randomized trial. The American Journal of Clinical Nutrition 100:4, pages 1059-1068.
Crossref
Norlida M. Daud, Nurhafzan A. Ismail, Elizabeth L. Thomas, Julie A. Fitzpatrick, Jimmy D. Bell, Jonathan R. Swann, Adele Costabile, Caroline E. Childs, Camilla Pedersen, Anthony P. Goldstone & Gary S. Frost. (2014) The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. Obesity 22:6, pages 1430-1438.
Crossref
Mohammad M. Monir, Kohzy Hiramatsu, Sachiko Matsumoto, Kei Nishimura, Chihiro Takemoto, Tomomi Shioji, Takafumi Watanabe, Kazumi Kita, Shinichi Yonekura & Sang Gun Roh. (2014) Influences of protein ingestion on glucagon-like peptide (GLP)-1-immunoreactive endocrine cells in the chicken ileum. Animal Science Journal 85:5, pages 581-587.
Crossref
Toru Kato & Koichi Node. (2014) Therapeutic Potential of α-Glucosidase Inhibitors to Prevent Postprandial Endothelial Dysfunction. International Heart Journal 55:5, pages 386-390.
Crossref
Mitsuyoshi Takahara, Toshihiko Shiraiwa, Naoto Katakami, Hideaki Kaneto, Taka-aki Matsuoka & Iichiro Shimomura. (2014) Efficacy of adding once- and thrice-daily voglibose in Japanese type 2 diabetic patients treated with alogliptin. Endocrine Journal 61:5, pages 447-456.
Crossref
Eberhard Standl, Michael J Theodorakis, Michael Erbach, Oliver Schnell & Jaakko Tuomilehto. (2014) On the potential of acarbose to reduce cardiovascular disease. Cardiovascular Diabetology 13:1, pages 81.
Crossref
Ronald CW Ma. (2014) Acarbose: an alternative to metformin for first-line treatment in type 2 diabetes?. The Lancet Diabetes & Endocrinology 2:1, pages 6-7.
Crossref
Miao-yan Zheng, Ju-hong Yang, Chun-yan Shan, Hong-tao Zhou, Yan-guang Xu, Ying Wang, Hui-zhu Ren, Bao-cheng Chang & Li-ming Chen. (2013) Effects of 24-week treatment with acarbose on glucagon-like peptide 1 in newly diagnosed type 2 diabetic patients: a preliminary report. Cardiovascular Diabetology 12:1.
Crossref
Tongzhi Wu, Christopher K Rayner, Richard L Young & Michael Horowitz. (2013) Gut motility and enteroendocrine secretion. Current Opinion in Pharmacology 13:6, pages 928-934.
Crossref
Tongzhi Wu, Michelle J. Bound, Beiyi R. Zhao, Scott D. Standfield, Max Bellon, Karen L. Jones, Michael Horowitz & Christopher K. Rayner. (2013) Effects of a d -Xylose Preload With or Without Sitagliptin on Gastric Emptying, Glucagon-Like Peptide-1, and Postprandial Glycemia in Type 2 Diabetes . Diabetes Care 36:7, pages 1913-1918.
Crossref
Tongzhi Wu, Michelle J. Bound, Scott D. Standfield, Karen L. Jones, Michael Horowitz & Christopher K. Rayner. (2013) Effects of Taurocholic Acid on Glycemic, Glucagon-like Peptide-1, and Insulin Responses to Small Intestinal Glucose Infusion in Healthy Humans. The Journal of Clinical Endocrinology & Metabolism 98:4, pages E718-E722.
Crossref
Shauna S. Runchey, Liisa M. Valsta, Yvonne Schwarz, Chiachi Wang, Xiaoling Song, Johanna W. Lampe & Marian L. Neuhouser. (2013) Effect of low- and high-glycemic load on circulating incretins in a randomized clinical trial. Metabolism 62:2, pages 188-195.
Crossref
Yoshiki Kusunoki, Tomoyuki Katsuno, Makiko Myojin, Kana Miyakoshi, Takashi Ikawa, Toshihiro Matsuo, Fumihiro Ochi, Masaru Tokuda, Kazuki Murai, Masayuki Miuchi, Tomoya Hamaguchi, Jun-ichiro Miyagawa & Mitsuyoshi Namba. (2013) Effect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptin. Endocrine Journal 60:4, pages 431-439.
Crossref
Yoshiharu Tsubamoto & Moritaka Goto. (2013) Preclinical and clinical aspects of the dipeptidyl peptidase-4 inhibitor anagliptin. Folia Pharmacologica Japonica 141:6, pages 339-349.
Crossref
Darleen Sandoval, Jason G. Barrera, Margaret A. Stefater, Stephanie Sisley, Stephen C. Woods, David D. D’Alessio & Randy J. Seeley. (2012) The Anorectic Effect of GLP-1 in Rats Is Nutrient Dependent. PLoS ONE 7:12, pages e51870.
Crossref
Fiona M. Gribble. (2012) The gut endocrine system as a coordinator of postprandial nutrient homoeostasis. Proceedings of the Nutrition Society 71:4, pages 456-462.
Crossref
Toshihide Shibazaki, Masaki Tomae, Yukiko Ishikawa-Takemura, Nobuhiko Fushimi, Fumiaki Itoh, Mitsuhiko Yamada & Masayuki Isaji. (2012) KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models. Journal of Pharmacology and Experimental Therapeutics 342:2, pages 288-296.
Crossref
Gary Wang, Keesandra Agenor, Justine Pizot, Donald P. Kotler, Yaniv Harel, Bart J. Van Der Schueren, Iliana Quercia, James McGinty & Blandine Laferrère. (2012) Accelerated Gastric Emptying but No Carbohydrate Malabsorption 1 Year After Gastric Bypass Surgery (GBP). Obesity Surgery 22:8, pages 1263-1267.
Crossref
Eberhard Standl & Oliver Schnell. (2012) Alpha-glucosidase inhibitors 2012 – cardiovascular considerations and trial evaluation. Diabetes and Vascular Disease Research 9:3, pages 163-169.
Crossref
Jingchuan Zhang & Robert C. Ritter. (2012) Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302:2, pages R264-R273.
Crossref
Tongzhi Wu, Beiyi R Zhao, Michelle J Bound, Helen L Checklin, Max Bellon, Tanya J Little, Richard L Young, Karen L Jones, Michael Horowitz & Christopher K Rayner. (2012) Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. The American Journal of Clinical Nutrition 95:1, pages 78-83.
Crossref
Jens Juul Holst & Maria A. McGill. (2012) Potential New Approaches to Modifying Intestinal GLP-1 Secretion in Patients with Type 2 Diabetes Mellitus. Clinical Drug Investigation 32:1, pages 1-14.
Crossref
Jean-Louis Chiasson, Markku Laakso & Markolf Hanefeld. 2012. Prevention of Type 2 Diabetes. Prevention of Type 2 Diabetes 167 187 .
Katie Colbert Coate, Guillaume Kraft, Margaret Lautz, Marta Smith, Doss W. Neal & Alan D. Cherrington. (2011) A High-Fat, High-Fructose Diet Accelerates Nutrient Absorption and Impairs Net Hepatic Glucose Uptake in Response to a Mixed Meal in Partially Pancreatectomized Dogs,. The Journal of Nutrition 141:9, pages 1643-1651.
Crossref
D. Gentilcore, L. Vanis, J. M. Wishart, C. K. Rayner, M. Horowitz & K. L. Jones. (2011) The Alpha ( )-Glucosidase Inhibitor, Acarbose, Attenuates the Blood Pressure and Splanchnic Blood Flow Responses to Intraduodenal Sucrose in Older Adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 66A:8, pages 917-924.
Crossref
Yukio Horikawa, Mayumi Enya, Katsumi Iizuka, Gui Ying Chen, Shin-ichi Kawachi, Tetsuya Suwa & Jun Takeda. (2011) Synergistic effect of α-glucosidase inhibitors and dipeptidyl peptidase 4 inhibitor treatment. Journal of Diabetes Investigation 2:3, pages 200-203.
Crossref
Tohru HIRA, Maya MURAMATSU, Masahiro OKUNO & Hiroshi HARA. (2011) GLP-1 Secretion in Response to Oral and Luminal Palatinose (Isomaltulose) in Rats. Journal of Nutritional Science and Vitaminology 57:1, pages 30-35.
Crossref
Michael A. Nauck. (2011) Incretin-Based Therapies for Type 2 Diabetes Mellitus: Properties, Functions, and Clinical Implications. The American Journal of Medicine 124:1, pages S3-S18.
Crossref
Mihai Covasa & Timothy Swartz. 2011. Handbook of Behavior, Food and Nutrition. Handbook of Behavior, Food and Nutrition 189 201 .
H. Wittenburg, U. Tennert & J. Mössner. (2010) Hormonale und metabolische Funktionen des DünndarmsHormonal and metabolic functions of the small intestine. Der Internist 51:6, pages 695-701.
Crossref
A. Vrieze, F. Holleman, E. G. Zoetendal, W. M. de Vos, J. B. L. Hoekstra & M. Nieuwdorp. (2010) The environment within: how gut microbiota may influence metabolism and body composition. Diabetologia 53:4, pages 606-613.
Crossref
Y. Moritoh, K. Takeuchi & M. Hazama. (2010) Combination treatment with alogliptin and voglibose increases active GLP‐1 circulation, prevents the development of diabetes and preserves pancreatic beta‐cells in prediabetic db/db mice . Diabetes, Obesity and Metabolism 12:3, pages 224-233.
Crossref
Bo Ahrén, Richard D. Carr & Carolyn F. Deacon. 2010. Incretins and Insulin Secretion. Incretins and Insulin Secretion 203 220 .
Tongzhi Wu, Christopher K. Rayner, Karen Jones & Michael Horowitz. 2010. Incretins and Insulin Secretion. Incretins and Insulin Secretion 81 110 .
E.J. Verspohl. (2009) Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacology & Therapeutics 124:1, pages 113-138.
Crossref
Jing Ma, Christopher K. Rayner, Karen L. Jones & Michael Horowitz. (2009) Insulin secretion in healthy subjects and patients with Type 2 diabetes – role of the gastrointestinal tract. Best Practice & Research Clinical Endocrinology & Metabolism 23:4, pages 413-424.
Crossref
Yusuke Moritoh, Koji Takeuchi & Masatoshi Hazama. (2009) Chronic Administration of Voglibose, an α-Glucosidase Inhibitor, Increases Active Glucagon-Like Peptide-1 Levels by Increasing Its Secretion and Decreasing Dipeptidyl Peptidase-4 Activity in ob/ob Mice . Journal of Pharmacology and Experimental Therapeutics 329:2, pages 669-676.
Crossref
t. edholm, k. cejvan, s. m. Abdel-halim, s. efendic, p. t. schmidt & p. m. hellström. (2009) The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility. Neurogastroenterology & Motility 21:3, pages 313-321.
Crossref
Richard D Mattes & Barry M Popkin. (2009) Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. The American Journal of Clinical Nutrition 89:1, pages 1-14.
Crossref
Reawika Chaikomin, Keng-Liang Wu, Selena Doran, James H. Meyer, Karen L. Jones, Christine Feinle-Bisset, Michael Horowitz & Christopher K. Rayner. (2008) Effects of mid-jejunal compared to duodenal glucose infusion on peptide hormone release and appetite in healthy men. Regulatory Peptides 150:1-3, pages 38-42.
Crossref
Markolf Hanefeld, Frank Schaper & Carsta Koehler. (2008) Effect of Acarbose on Vascular Disease in Patients with Abnormal Glucose Tolerance. Cardiovascular Drugs and Therapy 22:3, pages 225-231.
Crossref
Kyo-Yeol Hwang, Young-Hoon Kim, Yong-Seok Cho, Young-Shik Park, Jae-Yeon Lee, Kyung-Don Kang, Keun Kim, Dong-Kwan Joo, Duk-Kyun Ahn & Su-Il Seong. (2008) Hypoglycemic Effect of Fermented Soybean Culture Mixed with Mulberry Leaves on Neonatal Streptozotocin-Induced Diabetic Rats. Journal of the Korean Society of Food Science and Nutrition 37:4, pages 452-458.
Crossref
Darleen SandovalDaniela CotaRandy J. Seeley. (2008) The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation. Annual Review of Physiology 70:1, pages 513-535.
Crossref
Angela M Abbatecola, Stefania Maggi & Giuseppe Paolisso. (2008) New Approaches to Treating Type 2 Diabetes Mellitus in the Elderly. Drugs & Aging 25:11, pages 913-925.
Crossref
F. Xavier Pi-Sunyer. (2008) Avances en el tratamiento de la diabetes mellitus tipo 2 y la enfermedad cardiovascular. Revista Española de Cardiología Suplementos 8:3, pages 62C-72C.
Crossref
Markolf Hanefeld. 2007. Type 2 Diabetes. Type 2 Diabetes 121 134 .
Jens Juul Holst. (2007) The Physiology of Glucagon-like Peptide 1. Physiological Reviews 87:4, pages 1409-1439.
Crossref
Rania Abou Samra & G Harvey Anderson. (2007) Insoluble cereal fiber reduces appetite and short-term food intake and glycemic response to food consumed 75 min later by healthy men. The American Journal of Clinical Nutrition 86:4, pages 972-979.
Crossref
Stefano Del Prato, Cristina Bianchi & Piero Marchetti. (2007) ß‐cell function and anti‐diabetic pharmacotherapy. Diabetes/Metabolism Research and Reviews 23:7, pages 518-527.
Crossref
D. Maggs, I. MacDonald & M. A. Nauck. (2007) Glucose homeostasis and the gastrointestinal tract: insights into the treatment of diabetes. Diabetes, Obesity and Metabolism 0:0, pages 070509203705001-???.
Crossref
Bernardo L. Wajchenberg. (2007) β-Cell Failure in Diabetes and Preservation by Clinical Treatment. Endocrine Reviews 28:2, pages 187-218.
Crossref
Ji-Yeon HwangJian ZhangMin-Jung KangSoo-Kyung LeeHyun-A KimJong-Jin KimJung-In Kim. (2007) Hypoglycemic and hypolipidemic effects of Saururus chinensis Baill in streptozotocin-induced diabetic rats. Nutrition Research and Practice 1:2, pages 100.
Crossref
Kazuto Yamazaki, Takashi Inoue, Nobuyuki Yasuda, Yoshiaki Sato, Tadashi Nagakura, Osamu Takenaka, Richard Clark, Takao Saeki & Isao Tanaka. (2007) Comparison of Efficacies of a Dipeptidyl Peptidase IV Inhibitor and α-Glucosidase Inhibitors in Oral Carbohydrate and Meal Tolerance Tests and the Effects of Their Combination in Mice. Journal of Pharmacological Sciences 104:1, pages 29-38.
Crossref
Filip K. Knop, Tina Vilsbøll, Steen Larsen, Patricia V. Højberg, Aage Vølund, Sten Madsbad, Jens J. Holst & Thure Krarup. (2007) Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. American Journal of Physiology-Endocrinology and Metabolism 292:1, pages E324-E330.
Crossref
Markolf Hanefeld & Frank Schaper. 2007. Pharmacotherapy of Diabetes: New Developments. Pharmacotherapy of Diabetes: New Developments 143 152 .
Stephen C. Woods. (2006) Dietary Synergies in Appetite Control: Distal Gastrointestinal Tract. Obesity 14:7S, pages S171-S178.
Crossref
Yuichi Shinoda, Ikuo Inoue, Takanari Nakano, Makoto Seo, Masatoshi Sassa, Sei-ichi Goto, Takuya Awata, Tsugikazu Komoda & Shigehiro Katayama. (2006) Acarbose improves fibrinolytic activity in patients with impaired glucose tolerance. Metabolism 55:7, pages 935-939.
Crossref
Renate E Wachters-Hagedoorn, Marion G Priebe, Janneke A J Heimweg, A. Marius Heiner, Klaus N Englyst, Jens J Holst, Frans Stellaard & Roel J Vonk. (2006) The Rate of Intestinal Glucose Absorption Is Correlated with Plasma Glucose-Dependent Insulinotropic Polypeptide Concentrations in Healthy Men. The Journal of Nutrition 136:6, pages 1511-1516.
Crossref
Michael J. Theodorakis, Olga Carlson, Spyros Michopoulos, Máire E. Doyle, Magdalena Juhaszova, Kalliopi Petraki & Josephine M. Egan. (2006) Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. American Journal of Physiology-Endocrinology and Metabolism 290:3, pages E550-E559.
Crossref
Matthew C. Riddle & Daniel J. Drucker. (2006) Emerging Therapies Mimicking the Effects of Amylin and Glucagon-Like Peptide 1. Diabetes Care 29:2, pages 435-449.
Crossref
Guillaume Charpentier, Jean-Pierre Riveline, Dured Dardari & Michel Varroud-Vial. (2006) Should Postprandial Hyperglycaemia in Prediabetic and Type 2 Diabetic Patients be Treated?. Drugs 66:3, pages 273-286.
Crossref
Diana Gentilcore, Belynda Bryant, Judith M. Wishart, Howard A. Morris, Michael Horowitz & Karen L. Jones. (2005) Acarbose attenuates the hypotensive response to sucrose and slows gastric emptying in the elderly. The American Journal of Medicine 118:11, pages 1289.e5-1289.e11.
Crossref
Philip J. Larsen & Jens Juul Holst. (2005) Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter. Regulatory Peptides 128:2, pages 97-107.
Crossref
K. Hücking, Z. Kostic, C. Pox, R. Ritzel, J. J. Holst, W. Schmiegel & M. A. Nauck. (2005) α-Glucosidase inhibition (acarbose) fails to enhance secretion of glucagon-like peptide 1 (7-36 amide) and to delay gastric emptying in Type 2 diabetic patients. Diabetic Medicine 22:4, pages 470-476.
Crossref
O Andersen, SB Haugaard, JJ Holst, CF Deacon, J Iversen, UB Andersen, JO Nielsen & S Madsbad. (2005) Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy. HIV Medicine 6:2, pages 91-98.
Crossref
Matthew C. Riddle. (2005) Glycemic Management of Type 2 Diabetes: An Emerging Strategy with Oral Agents, Insulins, and Combinations. Endocrinology and Metabolism Clinics of North America 34:1, pages 77-98.
Crossref
Gabriel I. Uwaifo & Robert E. Ratner. (2005) Novel Pharmacologic Agents for Type 2 Diabetes. Endocrinology and Metabolism Clinics of North America 34:1, pages 155-197.
Crossref
April D. Strader & Stephen C. Woods. (2005) Gastrointestinal hormones and food intake. Gastroenterology 128:1, pages 175-191.
Crossref
Michael A. Nauck, Birgit Baller & Juris J. Meier. (2004) Gastric Inhibitory Polypeptide and Glucagon-Like Peptide-1 in the Pathogenesis of Type 2 Diabetes. Diabetes 53:suppl_3, pages S190-S196.
Crossref
T. Vilsbøll & J. J. Holst. (2004) Incretins, insulin secretion and Type 2 diabetes mellitus. Diabetologia 47:3, pages 357-366.
Crossref
Patricia L Brubaker & Younes Anini. (2003) Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. Canadian Journal of Physiology and Pharmacology 81:11, pages 1005-1012.
Crossref
Fiona M. Gribble, Leanne Williams, Anna K. Simpson & Frank Reimann. (2003) A Novel Glucose-Sensing Mechanism Contributing to Glucagon-Like Peptide-1 Secretion From the GLUTag Cell Line. Diabetes 52:5, pages 1147-1154.
Crossref
Andr?? J Scheen. (2003) Is There a Role for ??-Glucosidase Inhibitors in the Prevention of Type 2 Diabetes Mellitus?. Drugs 63:10, pages 933-951.
Crossref
Frank ReimannFiona M. Gribble. (2002) Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells. Diabetes 51:9, pages 2757-2763.
Crossref
G-I. HEMRE, T.P. MOMMSEN & Å. KROGDAHL. (2002) Carbohydrates in fish nutrition: effects on growth, glucose metabolism and hepatic enzymes. Aquaculture Nutrition 8:3, pages 175-194.
Crossref
Mary Jeanne DeLeon, Vikram Chandurkar, Stewart G Albert & Arshag D Mooradian. (2002) Glucagon-like peptide-1 response to acarbose in elderly type 2 diabetic subjects. Diabetes Research and Clinical Practice 56:2, pages 101-106.
Crossref
Jens J. Holst. (2002) Gastric Inhibitory Polypeptide Analogues. BioDrugs 16:3, pages 175-181.
Crossref
Heiner Laube. (2002) Acarbose. Clinical Drug Investigation 22:3, pages 141-156.
Crossref
Feruze Y. EnçNeşe I˙meryüzLevent Akin, Turgut TuroğluFuat DedeGonca HaklarNi˙lgün Tekeşi˙nNural Beki˙roğlu, BerrakÇ. Yeğen, Jens F. Rehfeld, Jens J. Holst & Nefi˙se B. Ulusoy. (2001) Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release. American Journal of Physiology-Gastrointestinal and Liver Physiology 281:3, pages G752-G763.
Crossref
A Flint, A Raben, AK Ersbøll, JJ Holst & A Astrup. (2001) The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity. International Journal of Obesity 25:6, pages 781-792.
Crossref
Gabriele Mertes. (2001) Safety and efficacy of acarbose in the treatment of Type 2 diabetes: data from a 5-year surveillance study. Diabetes Research and Clinical Practice 52:3, pages 193-204.
Crossref
C. Rosak. 2001. Klinische Diabetologie. Klinische Diabetologie 123 151 .
John C. Mathers & Mark E. Daly. 2000. Advanced Dietary Fibre Technology. Advanced Dietary Fibre Technology 186 196 .
A Flint, A Raben, JF Rehfeld, JJ Holst & A Astrup. (2000) The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans. International Journal of Obesity 24:3, pages 288-298.
Crossref
L Ranganath & L Morgan. (2000) An osmotic stimulus-mediating glucagon-like peptide-1 (7-36 amide) (GLP-1) secretion in acarbose-induced sucrose malabsorption?. Nutrition 16:1, pages 64-65.
Crossref
TAKENAO HASEGAWA, MASASHI YONEDA, KIMIHIDE NAKAMURA, KUNIYO OHNISHI, HIROYUKI HARADA, TAKESHI KYOUDA, YOSHIKAZU YOSHIDA & ISAO MAKINO. (1998) Long-term effect of α-glucosidase inhibitor on late dumping syndrome. Journal of Gastroenterology and Hepatology 13:12, pages 1201-1206.
Crossref
TAKENAO HASEGAWA, MASASHI YONEDA, KIMIHIDE NAKAMURA, KUNIYO OHNISHI, HIROYUKI HARADA, TAKESHI KYOUDA, YOSHIKAZU YOSHIDA & ISAO MAKINO. (2008) Long‐term effect of α‐glucosidase inhibitor on late dumping syndrome. Journal of Gastroenterology and Hepatology 13:12, pages 1201-1206.
Crossref
Burkhard Lorenz Herrmann, Helmut Schatz & Andreas Pfeiffer. (1998) Kontinuierliche Blutglucosemessungen: Der Akuteffekt von Acarbose auf die BlutglucoseschwankungenContinuous blood glucose measurements: the acute effect of acarbose of the blood glucose amplitudes. Medizinische Klinik 93:11, pages 651-655.
Crossref
Markolf Hanefeld. (1998) The Role of Acarbose in the Treatment of Non–Insulin-Dependent Diabetes Mellitus. Journal of Diabetes and its Complications 12:4, pages 228-237.
Crossref
Gabriele Mertes. (1998) Efficacy and safety of acarbose in the treatment of Type 2 diabetes: data from a 2-year surveillance study. Diabetes Research and Clinical Practice 40:1, pages 63-70.
Crossref
Harold E. Lebovitz. (1997) ALPHA-GLUCOSIDASE INHIBITORS. Endocrinology and Metabolism Clinics of North America 26:3, pages 539-551.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.