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Scandinavian Journal of Infectious Diseases Volume 29, 1997 - Issue 2
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CaseReport Article

Halofantrine-associated Ventricular Fibrillation in a Young Woman with no Predisposing QTc Prolongation

Svein Gunnar Gundersen Department of Infectious Diseases, University of Oslo, Oslo, Norway
,
Morten Rostrup Division of Acute Medicine, Ullevaal Hospital, University of Oslo, Oslo, Norway
,
Elisabeth Von Der Lippe Department of Infectious Diseases, University of Oslo, Oslo, Norway
,
Eivind S. Platou Department of Cardiology, Division of Medicine, University of Oslo, Oslo, Norway
,
Bjoern Myrvang Department of Infectious Diseases, University of Oslo, Oslo, Norway
&
Geoffrey Edwards Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
Pages 207-208 | Received 30 Sep 1996, Accepted 28 Nov 1996, Published online: 08 Jul 2009

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Rana Chattopadhyay, Babita Mahajan & Sanjai Kumar. (2007) Assessment of safety of the major antimalarial drugs. Expert Opinion on Drug Safety 6:5, pages 505-521.
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Kristen Bova Campbell. 2022. Torsades de Pointes. Torsades de Pointes 231 266 .
T.H. Grasela, V. Lukacova, D.N. Morris, R.D. Clark, K.A. Andrews & M.B. Bolger. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 51 82 .
S. Krudsood, S. Looareesuwan, P. Wilairatama, W. Leowattana, N. Tangpukdee, K. Chalermrut, S. Ramanathan, V. Navaratnam, P. Olliaro, M. Vaillant, J. R. Kiechel & W. R. J. Taylor. (2011) Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand . Tropical Medicine & International Health 16:4, pages 458-465.
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Olivier Bouchaud, Patrick Imbert, Jean Etienne Touze, Alex NO Dodoo, Martin Danis & Fabrice Legros. (2009) Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base. Malaria Journal 8:1.
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J. Simkó, A. Csilek, J. Karászi & I. Lőrincz. (2008) Proarrhythmic Potential of Antimicrobial Agents. Infection 36:3, pages 194-206.
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Jean-Étienne Touze, Philippe Heno, Laurent Fourcade & Philippe Paule. (2006) L’impact des antipaludiques sur la cellule myocardique. Approche pathogénique et nouvelles recommandations thérapeutiques. Bulletin de l'Académie Nationale de Médecine 190:2, pages 439-452.
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. 2004. Acquired Long QT Syndrome. Acquired Long QT Syndrome 121 139 .
W Robert J Taylor & Nicholas J White. (2004) Antimalarial Drug Toxicity. Drug Safety 27:1, pages 25-61.
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Yee Guan Yap & A. John Camm. 2003. Quinolone Antimicrobial Agents. Quinolone Antimicrobial Agents 421 440 .
Olivier Bouchaud, Fabrice Bruneel, Ricarda Schiemann, Gilles Peytavin & Jean P. Coulaud. (2006) Severe Cardiac Toxicity due to Halofantrine: Importance of Underlying Heart Disease. Journal of Travel Medicine 9:4, pages 214-215.
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I Lavallée, E Marc, F Moulin, J.M Treluyer, P Imbert & D Gendrel. (2001) Troubles du rythme et allongement de l’espace QT sous halofantrine. Archives de Pédiatrie 8:8, pages 795-800.
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Darrell R. Abernethy, David L. Wesche, Jean T. Barbey, Colin Ohrt, Sarina Mohanty, John C. Pezzullo & Brian G. Schuster. (2008) Stereoselective halofantrine disposition and effect:concentration‐related QTc prolongation. British Journal of Clinical Pharmacology 51:3, pages 231-237.
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D. Malvy, M. C. Receveur, P. Ozon, F. Djossou, PH. Le Metayer, J. E. Touze, M. Longy-Boursier & M. Le Bras. (2006) Fatal Cardiac Incident after Use of Halofantrine. Journal of Travel Medicine 7:4, pages 215-216.
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J.E. Touze, P. Heno, L. Fourcade, J.C. Deharo, B. Mafart & X. Lemaitre. (1999) La toxicité cardiaque des antipaludéens. Médecine et Maladies Infectieuses 29, pages S316-S325.
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C. Olivier, C. Rizk, D. Zhang & E. Jacqz-Aigrain. (1999) Allongement de l'espace QTc compliquant la prescription d'halofantrine chez deux enfants présentant un accès palustre à Plasmodium falciparum. Archives de Pédiatrie 6:9, pages 966-970.
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Isabela Ribeiro, Charles Woodrow & Sanjeev Krishna. 1999. 302 316 .

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