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Original

Comparison of different approaches to predict metabolic drug–drug interactions

Pages 1257-1294 | Received 03 Jun 2007, Accepted 15 Aug 2007, Published online: 12 Jul 2010

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Crossref
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Crossref
Frédéric Y. Bois. (2010) Physiologically Based Modelling and Prediction of Drug Interactions. Basic & Clinical Pharmacology & Toxicology 106:3, pages 154-161.
Crossref
Aleksandra Galetin & J. Brian Houston. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 315 343 .
Amin Rostami‐Hodjegan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 549 568 .

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