Xenobiotica, Volume 37, Issue 10-11 (2007)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 37, Issue 10-11 (2007)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Volume 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

Editorial

Editorial
Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro–in vivo extrapolations (IVIVE)
Pages: 1013-1014
Published online: 22 Sep 2008
CitationforModelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro–in vivo extrapolations (IVIVE) | Full Text | References | PDF (25.6 KB)
  • 767 Views
  • 13 CrossRef citations
  • 0Altmetric
Free Access

Research Article

Article
Intestinal permeability and its relevance for absorption and elimination
H. Lennernäs
Pages: 1015-1051
Published online: 29 Aug 2013
AbstractforIntestinal permeability and its relevance for absorption and elimination | PDF (364.7 KB)
  • 1361 Views
  • 225 CrossRef citations
  • 0Altmetric
Article
Modelling and simulation in drug absorption processes
A. Dokoumetzidis, G. Valsami & P. Macheras
Pages: 1052-1065
Published online: 22 Sep 2008
AbstractforModelling and simulation in drug absorption processes | Full Text | References | PDF (206.7 KB)
  • 427 Views
  • 15 CrossRef citations
  • 0Altmetric
Article
In vitro–in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations
O. Pelkonen & M. Turpeinen
Pages: 1066-1089
Published online: 22 Sep 2008
AbstractforIn vitro–in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations | Full Text | References | PDF (305.3 KB)
  • 1446 Views
  • 86 CrossRef citations
  • 0Altmetric
Article
In vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects
P. J. H. Webborn, A. J. Parker, R. L. Denton & R. J. Riley
Pages: 1090-1109
Published online: 05 Jan 2010
AbstractforIn vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects | Full Text | References | PDF (160.5 KB)
  • 684 Views
  • 15 CrossRef citations
  • 0Altmetric
Article
Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake
M. Baker & T. Parton
Pages: 1110-1134
Published online: 22 Sep 2008
AbstractforKinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake | Full Text | References | PDF (1.8 MB)
  • 1030 Views
  • 75 CrossRef citations
  • 0Altmetric
Article
Challenges for blood–brain barrier (BBB) screening
P. Jeffrey & S. G. Summerfield
Pages: 1135-1151
Published online: 22 Sep 2008
AbstractforChallenges for blood–brain barrier (BBB) screening | Full Text | References | PDF (118.6 KB)
  • 579 Views
  • 66 CrossRef citations
  • 0Altmetric
Article
Future directions for drug transporter modelling
S. Ekins, G. F. Ecker, P. Chiba & P. W. Swaan
Pages: 1152-1170
Published online: 22 Sep 2008
AbstractforFuture directions for drug transporter modelling | Full Text | References | PDF (1 MB)
  • 278 Views
  • 47 CrossRef citations
  • 0Altmetric
Article
Transporter-mediated uptake into cellular compartments
S. Oswald, M. Grube, W. Siegmund & H. K. Kroemer
Pages: 1171-1195
Published online: 22 Sep 2008
AbstractforTransporter-mediated uptake into cellular compartments | Full Text | References | PDF (267 KB)
  • 416 Views
  • 32 CrossRef citations
  • 0Altmetric
Article
Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations
N. J. Hewitt, E. L. Lecluyse & S. S. Ferguson
Pages: 1196-1224
Published online: 22 Sep 2008
AbstractforInduction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations | Full Text | References | PDF (377.3 KB)
  • 1795 Views
  • 147 CrossRef citations
  • 0Altmetric
Article
Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment
K. Venkatakrishnan, R. S. Obach & A. Rostami-Hodjegan
Pages: 1225-1256
Published online: 22 Sep 2008
AbstractforMechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment | Full Text | References | PDF (385.7 KB)
  • 745 Views
  • 63 CrossRef citations
  • 0Altmetric

Original

Article
Comparison of different approaches to predict metabolic drug–drug interactions
H. J. Einolf
Pages: 1257-1294
Published online: 12 Jul 2010
AbstractforComparison of different approaches to predict metabolic drug–drug interactions | Full Text | References | PDF (300 KB)
  • 569 Views
  • 45 CrossRef citations
  • 0Altmetric

Research Article

Article
Challenges and opportunities with modelling and simulation in drug discovery and drug development
T. Lavé, N. Parrott, H. P. Grimm, A. Fleury & M. Reddy
Pages: 1295-1310
Published online: 22 Sep 2008
AbstractforChallenges and opportunities with modelling and simulation in drug discovery and drug development | Full Text | References | PDF (231.8 KB)
  • 853 Views
  • 87 CrossRef citations
  • 0Altmetric

Original

Article
Design of population pharmacokinetic experiments using prior information
K. Ogungbenro & L. Aarons
Pages: 1311-1330
Published online: 12 Jul 2010
AbstractforDesign of population pharmacokinetic experiments using prior information | Full Text | References | PDF (716.4 KB)
  • 222 Views
  • 8 CrossRef citations
  • 0Altmetric

Research Article

Article
On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development
P. J. Lowe, Y. Hijazi, O. Luttringer, H. Yin, R. Sarangapani & D. Howard
Pages: 1331-1354
Published online: 22 Sep 2008
AbstractforOn the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development | Full Text | References | PDF (288.1 KB)
  • 1600 Views
  • 76 CrossRef citations
  • 0Altmetric

Explore articles