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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 11
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Research Article

Metabolite screening of aromatic amine hair dyes using in vitro hepatic models

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Pages 811-825 | Received 07 May 2009, Accepted 22 Jun 2009, Published online: 21 Oct 2009

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Christine Götz, Nicola J. Hewitt, Erich Jermann, Julia Tigges, Zippora Kohne, Ulrike Hübenthal, Jean Krutmann, Hans F Merk & Ellen Fritsche. (2012) Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models. Xenobiotica 42:6, pages 526-537.
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Mariam R. Habil, Raúl A. Salazar-González, Mark A. Doll & David W. Hein. (2022) N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes. Archives of Toxicology 96:12, pages 3257-3263.
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Marie L. A. Schuttelaar, Cynthia C. A. van Amerongen, Jutta Lichter & Brunhilde Blömeke. (2019) Evaluation of risk modification for p ‐phenylenediamine sensitization by N ‐acetyltransferase 1 and 2 for two highly sensitive cases . Contact Dermatitis 81:2, pages 138-140.
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J. Lichter, U. Bock, C. Lotz, F. Groeber & B. Blömeke. (2017) Functional expression of N ‐acetyltransferase 1 in differentiated human skin keratinocytes . British Journal of Dermatology 177:3, pages 870-872.
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John Manwaring, Helga Rothe, Cindy Obringer, David J. Foltz, Timothy R. Baker, John A. Troutman, Nicola J. Hewitt & Carsten Goebel. (2015) Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro. Toxicology and Applied Pharmacology 287:2, pages 139-148.
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Gerhard J. Nohynek, Julie A. Skare, Wim J.A. Meuling, Kenneth R. Wehmeyer, Albertus Th H.J. de Bie, Wouter H.J. Vaes, Eric K. Dufour, Rolf Fautz, Winfried Steiling, Mario Bramante & Herve Toutain. (2015) Human systemic exposure to [ 14 C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment. Food and Chemical Toxicology 81, pages 71-80.
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Andreas Zeller & Stefan Pfuhler. (2014) N-acetylation of three aromatic amine hair dye precursor molecules eliminates their genotoxic potential. Mutagenesis 29:1, pages 37-48.
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K. Schroeder, K.D. Bremm, N. Alépée, J.G.M. Bessems, B. Blaauboer, S.N. Boehn, C. Burek, S. Coecke, L. Gombau, N.J. Hewitt, J. Heylings, J. Huwyler, M. Jaeger, M. Jagelavicius, N. Jarrett, H. Ketelslegers, I. Kocina, J. Koester, J. Kreysa, R. Note, A. Poth, M. Radtke, V. Rogiers, J. Scheel, T. Schulz, H. Steinkellner, M. Toeroek, M. Whelan, P. Winkler & W. Diembeck. (2011) Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors. Toxicology in Vitro 25:3, pages 589-604.
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Axel Schnuch, Götz Westphal, Rotraut Mössner, Wolfgang Uter & Kristian Reich. (2011) Genetic factors in contact allergy-review and future goals. Contact Dermatitis 64:1, pages 2-23.
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Gerhard J. Nohynek, Eric Antignac, Thomas Re & Herve Toutain. (2010) Safety assessment of personal care products/cosmetics and their ingredients. Toxicology and Applied Pharmacology 243:2, pages 239-259.
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