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Xenobiotica
the fate of foreign compounds in biological systems
Volume 39, 2009 - Issue 11
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Research Article

Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice

J. KuzeEvaluation Research Laboratory, Hanno Research Center, Taiho Pharmaceutical Co., Ltd, Saitama, Japan
,
T. MutohEvaluation Research Laboratory, Hanno Research Center, Taiho Pharmaceutical Co., Ltd, Saitama, Japan
,
T. TakenakaEvaluation Research Laboratory, Hanno Research Center, Taiho Pharmaceutical Co., Ltd, Saitama, Japan
,
K. MorisakiCharles River Laboratories Japan, Yokohama, Japan
,
H. NakuraLaboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
,
N. HaniokaLaboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanCorrespondence[email protected]
&
S. NarimatsuLaboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanCorrespondence[email protected]
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Pages 871-880 | Received 13 Jun 2009, Accepted 27 Jul 2009, Published online: 21 Oct 2009

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Run Li, Qingqing Wang, Zihou Liu, Like Xie, Zhipeng Diao, Ying Peng, Guangji Wang & Jianguo Sun. (2023) Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism. Xenobiotica 53:3, pages 184-192.
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Jinyuan Chen, Ziyun Yuan, Yifan Tu, Wanyu Hu, Cong Xie & Ling Ye. (2023) Experimental and computational models to investigate intestinal drug permeability and metabolism. Xenobiotica 53:1, pages 25-45.
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Amol A. Raje, Radni D. Deshpande, Vishal V. Pathade, Vallabh Mahajan, Kaushal Joshi, Ashwini Tambe, Ramana Jinugu, Vamsi L. M. Madgula, Ashwani Gaur, Vishwottam Kandikere, Chandragouda R. Patil & Kasim A. Mookhtiar. (2018) Evaluation of separate role of intestine and liver in first pass metabolism of budesonide in rat. Xenobiotica 48:12, pages 1206-1214.
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J. Kuze, T. Mutoh, T. Takenaka, N. Oda, N. Hanioka & S. Narimatsu. (2013) Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam. Xenobiotica 43:7, pages 598-606.
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Hiroshi Komura & Masahiro Iwaki. (2011) In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences. Drug Metabolism Reviews 43:4, pages 476-498.
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Laura Zonzini, Federica Bianchi, Nicola Cesari & Matteo Sartori. (2010) In vivo rat PK profiling in drug discovery: new challenges. Expert Opinion on Drug Discovery 5:11, pages 1031-1037.
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Articles from other publishers (9)

Yusuke Tanaka, Kazuhiro Ito, Takanori Kurakazu & Satoshi Kasaoka. (2023) Separate Evaluation of Fraction Absorbed and Intestinal Availability after Oral Administration of Drugs Based on the Measurement of Portal and Systemic Plasma Concentrations and Luminal Concentration. Molecular Pharmaceutics 20:4, pages 1933-1941.
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Leah R. Villegas, Christopher J. Rivard, Brandi Hunter, Zhiying You, Carlos Roncal, Melanie S. Joy & MyPhuong T. Le. (2018) Effects of fructose-containing sweeteners on fructose intestinal, hepatic, and oral bioavailability in dual-catheterized rats. PLOS ONE 13:11, pages e0207024.
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Ninad Varkhede, Nita Patel, William Chang, Kenneth Ruterbories & M. Laird Forrest. (2018) A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice. Pharmaceutical Research 35:8.
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Wenhui Tao, Dongyang Zhao, Mengchi Sun, Meng Li, Xiangyu Zhang, Zhonggui He, Yinghua Sun & Jin Sun. (2017) Enzymatic activation of double-targeted 5′-O-l-valyl-decitabine prodrug by biphenyl hydrolase-like protein and its molecular design basis. Drug Delivery and Translational Research 7:2, pages 304-311.
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Christoph Thiel, Sebastian Schneckener, Markus Krauss, Ahmed Ghallab, Ute Hofmann, Tobias Kanacher, Sebastian Zellmer, Rolf Gebhardt, Jan G. Hengstler & Lars Kuepfer. (2015) A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation. Journal of Pharmaceutical Sciences 104:1, pages 191-206.
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Lars Ole Schwen, Markus Krauss, Christoph Niederalt, Felix Gremse, Fabian Kiessling, Andrea Schenk, Tobias Preusser & Lars Kuepfer. (2014) Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver. PLoS Computational Biology 10:3, pages e1003499.
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Yoko Nagaya, Osamu Takenaka, Kazutomi Kusano & Tsutomu Yoshimura. (2013) Species Difference in the Mechanism of Nonlinear Pharmacokinetics of E2074, a Novel Sodium Channel Inhibitor, in Rats, Dogs, and Monkeys. Drug Metabolism and Disposition 41:5, pages 1004-1011.
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Yoshiki Matsuda, Yoshihiro Konno, Masahiro Satsukawa, Taro Kobayashi, Yu Takimoto, Kunihiko Morisaki & Shinji Yamashita. (2012) Assessment of Intestinal Availability of Various Drugs in the Oral Absorption Process Using Portal Vein-Cannulated Rats. Drug Metabolism and Disposition 40:12, pages 2231-2238.
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Nobuo Sekiguchi, Motohiro Kato, Maiko Takada, Hiroo Watanabe, Shotaro Takata, Tetsuya Mitsui, Yoshinori Aso & Masaki Ishigai. (2011) Quantitative Prediction of Mechanism-Based Inhibition Caused by Mibefradil in Rats. Drug Metabolism and Disposition 39:7, pages 1255-1262.
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