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Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 10
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Clinical Pharmacokinetics and Metabolism

Pharmacokinetic variability of voriconazole and N-oxide voriconazole measured as therapeutic drug monitoring

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Pages 701-706 | Received 21 Apr 2010, Accepted 21 Jun 2010, Published online: 19 Jul 2010

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Danillo F. M. C. Veloso, Naiara I. G. M. Benedetti, Renato I. Ávila, Thiago S. A. Bastos, Thaísa C. Silva, Maria R. R. Silva, Aline C. Batista, Marize C. Valadares & Eliana M. Lima. (2018) Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity. Drug Delivery 25:1, pages 1585-1594.
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Meng Lei, Hongping Yao, Yalin Dong, Maoyi Wang, Zheng Wang & Xiaoliang Cheng. (2017) Development and validation of an LC-MS/MS method for simultaneous quantification of voriconazole and its main metabolite voriconazole N-oxide in human plasma and its clinical application. Journal of Liquid Chromatography & Related Technologies 40:20, pages 1047-1053.
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Articles from other publishers (18)

Tatsuro Yamamoto, Masako Ishida, Nao Kodama, Yusuke Saiki, Masachika Fujiyoshi & Miki Shimada. (2023) Development of a New Method for Simultaneous Quantitation of Plasma Concentrations of Voriconazole and Voriconazole <i>N</i>-Oxide Using Column-Switching LC-MS/MS and Its Application in Therapeutic Drug Monitoring. Yonago Acta Medica.
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Su-jie Jia, Ke-qin Gao, Pan-hao Huang, Ren Guo, Xiao-cong Zuo, Qing Xia, Shuang-yao Hu, Zhen Yu & Yue-liang Xie. (2021) Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole. Frontiers in Pharmacology 12.
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Joseph Lee, Patrick Ng, Bassem Hamandi, Shahid Husain, Melissa J. Lefebvre & Marisa Battistella. (2020) Effect of Therapeutic Drug Monitoring and Cytochrome P450 2C19 Genotyping on Clinical Outcomes of Voriconazole: A Systematic Review. Annals of Pharmacotherapy, pages 106002802094817.
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Andreas H. Groll & Silke Gastine. 2020. Methods of Therapeutic Drug Monitoring Including Pharmacogenetics. Methods of Therapeutic Drug Monitoring Including Pharmacogenetics 185 224 .
Ren-ai Xu, Qianmeng Lin, Xiangjun Qiu, Jingjing Chen, Yuanyuan Shao, Guoxin Hu & Guanyang Lin. (2019) UPLC-MS/MS method for the simultaneous determination of imatinib, voriconazole and their metabolites concentrations in rat plasma. Journal of Pharmaceutical and Biomedical Analysis 166, pages 6-12.
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Alicia Gomez-Lopez, Laura Alcazar-Fuoli & Leticia Bernal-Martínez. (2018) Simultaneous quantification of systemic azoles and their major metabolites in human serum by HPLC/PDA: role of azole metabolic rate. Diagnostic Microbiology and Infectious Disease 92:1, pages 78-83.
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T.-y. Li, W. Liu, K. Chen, S.-y. Liang & F. Liu. (2017) The influence of combination use of CYP450 inducers on the pharmacokinetics of voriconazole: a systematic review. Journal of Clinical Pharmacy and Therapeutics 42:2, pages 135-146.
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M. A. Encalada Ventura, M. J. P. van Wanrooy, L. F. R. Span, M. G. G. Rodgers, E. R. van den Heuvel, D. R. A. Uges, T. S. van der Werf, J. G. W. Kosterink & J. W. C. Alffenaar. (2016) Longitudinal Analysis of the Effect of Inflammation on Voriconazole Trough Concentrations. Antimicrobial Agents and Chemotherapy 60:5, pages 2727-2731.
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H.-R. He, J.-Y. Sun, X.-D. Ren, T.-T. Wang, Y.-J. Zhai, S.-Y. Chen, Y.-L. Dong & J. Lu. (2014) Effects of CYP3A4 polymorphisms on the plasma concentration of voriconazole. European Journal of Clinical Microbiology & Infectious Diseases 34:4, pages 811-819.
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Meinolf Karthaus, Thomas Lehrnbecher, Hans-Peter Lipp, Stefan Kluge & Dieter Buchheidt. (2015) Therapeutic drug monitoring in the treatment of invasive aspergillosis with voriconazole in cancer patients—an evidence-based approach. Annals of Hematology 94:4, pages 547-556.
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Takahiro Yamada, Yasuaki Mino, Tatsuya Yagi, Takafumi Naito & Junichi Kawakami. (2015) Saturated Metabolism of Voriconazole <i>N</i>-Oxidation Resulting in Nonlinearity of Pharmacokinetics of Voriconazole at Clinical Doses. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 38:10, pages 1496-1503.
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Taotao Wang, Huifang Zhu, Jinyao Sun, Xiaoliang Cheng, Jiao Xie, Haiyan Dong, Limei Chen, Xue Wang, Jianfeng Xing & Yalin Dong. (2014) Efficacy and safety of voriconazole and CYP2C19 polymorphism for optimised dosage regimens in patients with invasive fungal infections. International Journal of Antimicrobial Agents 44:5, pages 436-442.
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T. Wang, S. Chen, J. Sun, J. Cai, X. Cheng, H. Dong, X. Wang, J. Xing, W. Dong, H. Yao & Y. Dong. (2013) Identification of factors influencing the pharmacokinetics of voriconazole and the optimization of dosage regimens based on Monte Carlo simulation in patients with invasive fungal infections. Journal of Antimicrobial Chemotherapy 69:2, pages 463-470.
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Jarrett R. Amsden, Paul O. Gubbins, Scott McConnell & Elias Anaissie. (2013) Steady-State Pharmacokinetics of Oral Voriconazole and Its Primary Metabolite, N -Oxide Voriconazole, Pre- and Post-Autologous Peripheral Stem Cell Transplantation . Antimicrobial Agents and Chemotherapy 57:7, pages 3420-3423.
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Pablo Solís-Muñoz, Juan Carlos López, William Bernal, Christopher Willars, Ana Verma, Michael A. Heneghan, Julia Wendon & Georg Auzinger. (2013) Voriconazole hepatotoxicity in severe liver dysfunction. Journal of Infection 66:1, pages 80-86.
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Julie Autmizguine, Maja Krajinovic, Julie Rousseau, Yves Théorêt, Catherine Litalien, Christopher Marquis, Bruce Tapiéro & Philippe Ovetchkine. (2012) Pharmacogenetics and beyond: variability of voriconazole plasma levels in a patient with primary immunodeficiency. Pharmacogenomics 13:16, pages 1961-1965.
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Jennifer Chen, Carol Chan, David Colantonio & Winnie Seto. (2012) Therapeutic Drug Monitoring of Voriconazole in Children. Therapeutic Drug Monitoring 34:1, pages 77-84.
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Takahiro Yamada, Yasuaki Mino, Tatsuya Yagi, Takafumi Naito & Junichi Kawakami. (2012) Rapid simultaneous determination of voriconazole and its N-oxide in human plasma using an isocratic high-performance liquid chromatography method and its clinical application. Clinical Biochemistry 45:1-2, pages 134-138.
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