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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 4
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General Xenobiochemistry

Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity

Harshica FernandoDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX, USA
,
Jessica A. O. RumfeldtSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
,
Nadezhda Y. DavydovaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USACorrespondence[email protected]
,
James R. HalpertSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
&
Dmitri R. DavydovSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
Pages 281-289 | Received 27 Sep 2010, Accepted 05 Nov 2010, Published online: 14 Dec 2010

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Glenn A. Marsch, Benjamin T. Carlson & F. Peter Guengerich. (2018) 7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites. Journal of Biomolecular Structure and Dynamics 36:4, pages 841-860.
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Articles from other publishers (12)

Haixing Li & Jed N. Lampe. (2019) Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism. Archives of Biochemistry and Biophysics 673, pages 108078.
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Ilia G. Denisov, Yelena V. Grinkova, Prithviraj Nandigrami, Mrinal Shekhar, Emad Tajkhorshid & Stephen G. Sligar. (2019) Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213. Biochemistry 58:10, pages 1411-1422.
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Martin Šrejber, Veronika Navrátilová, Markéta Paloncýová, Václav Bazgier, Karel Berka, Pavel Anzenbacher & Michal Otyepka. (2018) Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners. Journal of Inorganic Biochemistry 183, pages 117-136.
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Peter Hlavica. (2017) Challenges in assignment of allosteric effects in cytochrome P450-catalyzed substrate oxidations to structural dynamics in the hemoprotein architecture. Journal of Inorganic Biochemistry 167, pages 100-115.
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Ilia G. Denisov, Yelena V. Grinkova, Javier L. Baylon, Emad Tajkhorshid & Stephen G. Sligar. (2015) Mechanism of Drug–Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer. Biochemistry 54:13, pages 2227-2239.
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Irina F. Sevrioukova & Thomas L. Poulos. 2015. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450 83 105 .
Hyun-Hee Jang, Dmitri R. Davydov, Ga-Young Lee, Chul-Ho Yun & James R. Halpert. (2014) The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes. Archives of Biochemistry and Biophysics 545, pages 100-107.
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Elena V. Sineva, Jessica A. O. Rumfeldt, James R. Halpert & Dmitri R. Davydov. (2013) A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET). PLoS ONE 8:12, pages e83898.
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Dmitri R. Davydov, Gelii V. Ponomarev, Ekaterina Bobrovnikova-Marjon, Donovan C. Haines & Julian A. Peterson. (2013) Aluminum-substituted heme domain of P450BM-3 (BMP): Introducing a heme-derived fluorescent probe for studies of substrate binding and protein-protein interactions in cytochromes P450. Biotechnology and Applied Biochemistry 60:1, pages 41-51.
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Giovanna Di Nardo & Gianfranco Gilardi. (2012) Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites. International Journal of Molecular Sciences 13:12, pages 15901-15924.
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Ilia G. Denisov & Stephen G. Sligar. (2012) A novel type of allosteric regulation: Functional cooperativity in monomeric proteins. Archives of Biochemistry and Biophysics 519:2, pages 91-102.
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Dmitri R. Davydov, Jessica A.O. Rumfeldt, Elena V. Sineva, Harshica Fernando, Nadezhda Y. Davydova & James R. Halpert. (2012) Peripheral Ligand-binding Site in Cytochrome P450 3A4 Located with Fluorescence Resonance Energy Transfer (FRET). Journal of Biological Chemistry 287:9, pages 6797-6809.
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