Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 9
Submit an article Journal homepage
153
Views
10
CrossRef citations to date
0
Altmetric
Animal Pharmacokinetics and Metabolism

Identification of circulatory and excretory metabolites of a novel nitric oxide donor ZJM-289 in rat plasma, bile, urine and faeces by liquid chromatography–tandem mass spectrometry

Ning LiCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
,
Xuliang WangCenter of drug discovery, China Pharmaceutical University, Nanjing, China
,
Tingting LiDepartment of Pharmacology, China Pharmaceutical University, Nanjing, China
,
Hui JiDepartment of Pharmacology, China Pharmaceutical University, Nanjing, China
,
Yihua ZhangCenter of drug discovery, China Pharmaceutical University, Nanjing, China
,
Zhixia QiuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
,
Di ZhaoCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
&
Xijing ChenCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected]
 show all
Pages 805-817 | Received 18 Mar 2011, Accepted 08 Apr 2011, Published online: 11 May 2011

Citations (10)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Ning Li, Zhixia Qiu, Xuliang Wang, Tingting Li, Hui Ji, Yihua Zhang, Yang Lu, Di Zhao & Xijing Chen. (2014) Pharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor. Xenobiotica 44:1, pages 59-69.
Read now
Vanesa Stepanov, Karmen Stankov & Momir Mikov. (2013) The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders. Journal of Receptors and Signal Transduction 33:4, pages 213-223.
Read now

Articles from other publishers (8)

Xiaojie Fu, Ting Zheng, Zegeng Li & Huan Wu. (2023) Metabolic profiling of Qi‐Yu‐San‐Long decoction in rat feces by ultraperformance liquid chromatography–quadrupole time‐of‐flight mass spectrometry combined with a post‐targeted screening strategy. Biomedical Chromatography 37:12.
Crossref
Hairong Wang, Xiaobin Li, Haoyu Ye, Neng Qiu, Liang Ma, Chunyu Wang, Qiunan Yang, Minghai Tang, Li Wan & Lijuan Chen. (2016) Characterization of In Vivo Metabolites of a Potential Anti-obesity Compound, the 3-Methyl-1H-Purine-2,6-Dione Derivative C-11, Employing Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. Chromatographia 79:11-12, pages 693-702.
Crossref
Xingxing Diao, Zhiyu Ma, Haidong Wang, Dafang Zhong, Yifan Zhang, Jing Jin, Yaxin Fan & Xiaoyan Chen. (2013) Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC–MS/MS using deuterated internal standards. Journal of Pharmaceutical and Biomedical Analysis 78-79, pages 19-26.
Crossref
Xingxing Diao, Pan Deng, Cen Xie, Xiuli Li, Dafang Zhong, Yifan Zhang & Xiaoyan Chen. (2013) Metabolism and Pharmacokinetics of 3- n -Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation . Drug Metabolism and Disposition 41:2, pages 430-444.
Crossref
Lingli Zhang, Ning Li, Yisheng Lai, Yihua Zhang, Xijing Chen, Li Chen, Hui Ji & Cuiyun Li. (2012) Pharmacokinetic, Distribution, Metabolism, and Excretion of (Z)-2-Amino-1,5-Dihydro-1-Methyl-5-[4-(Mesyl)Benzylidene]-4H-Imidazol-4-One Mesilate (ZLJ-601) in Sprague-Dawley Rats. Pharmacology 89:3-4, pages 192-200.
Crossref
Qian Zhao, Chao Zhang, Xuliang Wang, Li Chen, Hui Ji & Yihua Zhang. (2012) (S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death. Neurochemistry International 60:2, pages 134-144.
Crossref
Yang Li, Xuliang Wang, Rong Fu, Wenying Yu, Xiaoli Wang, Yisheng Lai, Sixun Peng & Yihua Zhang. (2011) Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents. Bioorganic & Medicinal Chemistry Letters 21:14, pages 4210-4214.
Crossref
Xuliang Wang, Yang Li, Qian Zhao, Zhenli Min, Chao Zhang, Yisheng Lai, Hui Ji, Sixun Peng & Yihua Zhang. (2011) Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents. Organic & Biomolecular Chemistry 9:16, pages 5670.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.