Xenobiotica, Volume 41, Issue 9 (2011)

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Xenobiotica, Volume 41, Issue 9 (2011)

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General Xenobiochemistry

Article
Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases
Petra Jančová, Michal Šiller, Eva Anzenbacherová, Vladimír Křen, Pavel Anzenbacher & Vilím Šimánek
Pages: 743-751
Published online: 27 Apr 2011
AbstractforEvidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases | Full Text | References | PDF (854 KB)
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Article
Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters
Nicolas Picard, Laure Levoir, Fabien Lamoureux, Sook Wah Yee, Kathleen M. Giacomini & Pierre Marquet
Pages: 752-757
Published online: 27 Apr 2011
AbstractforInteraction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters | Full Text | References | PDF (670.4 KB) | Supplemental
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Article
Enantioselective carbonyl reduction of eperisone in human liver microsomes
Hye Hyun Yoo, Nam-Sun. Kim, Min Jung Kim, Dongyun Shin, Jae-Gook Shin & Dong-Hyun Kim
Pages: 758-763
Published online: 31 May 2011
AbstractforEnantioselective carbonyl reduction of eperisone in human liver microsomes | Full Text | References | PDF (724.9 KB) | Supplemental
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Article
Validation of membrane vesicle-based breast cancer resistance protein and multidrug resistance protein 2 assays to assess drug transport and the potential for drug–drug interaction to support regulatory submissions
Robert Elsby, Veronica Smith, Lisa Fox, David Stresser, Caroline Butters, Pradeep Sharma & Dominic D. Surry
Pages: 764-783
Published online: 25 May 2011
AbstractforValidation of membrane vesicle-based breast cancer resistance protein and multidrug resistance protein 2 assays to assess drug transport and the potential for drug–drug interaction to support regulatory submissions | Full Text | References | PDF (1.4 MB)
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Animal Pharmacokinetics and Metabolism

Article
The disposition and metabolism of zibotentan (ZD4054): an oral-specific endothelin A receptor antagonist in mice, rats and dogs
J.A. Clarkson-Jones, A.S.J. Kenyon & H.K. Tomkinson
Pages: 784-796
Published online: 10 Jun 2011
AbstractforThe disposition and metabolism of zibotentan (ZD4054): an oral-specific endothelin A receptor antagonist in mice, rats and dogs | Full Text | References | PDF (1 MB)
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Article
Effects of experimental hyperlipidaemia on the pharmacokinetics of docetaxel in rats
Joo Hyun Lee, Ju-Hee Oh & Young-Joo Lee
Pages: 797-804
Published online: 11 May 2011
AbstractforEffects of experimental hyperlipidaemia on the pharmacokinetics of docetaxel in rats | Full Text | References | PDF (682.1 KB)
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Article
Identification of circulatory and excretory metabolites of a novel nitric oxide donor ZJM-289 in rat plasma, bile, urine and faeces by liquid chromatography–tandem mass spectrometry
Ning Li, Xuliang Wang, Tingting Li, Hui Ji, Yihua Zhang, Zhixia Qiu, Di Zhao & Xijing Chen
Pages: 805-817
Published online: 11 May 2011
AbstractforIdentification of circulatory and excretory metabolites of a novel nitric oxide donor ZJM-289 in rat plasma, bile, urine and faeces by liquid chromatography–tandem mass spectrometry | Full Text | References | PDF (1.7 MB)
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Article
Bioconcentration and biotransformation of [14C]methoxychlor in the brackish water bivalve Corbicula japonica
Minoru Masuda, Kazutoshi Ohyama, Osamu Hayashi, Koji Satsuma & Kiyoshi Sato
Pages: 818-825
Published online: 27 Apr 2011
AbstractforBioconcentration and biotransformation of [14C]methoxychlor in the brackish water bivalve Corbicula japonica | Full Text | References | PDF (771.5 KB)
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Pharmacogenetics

Article
Evaluation of the effects of 18 non-synonymous single-nucleotide polymorphisms of CYP450 2C19 on in vitro drug inhibition potential by a fluorescence-based high-throughput assay
Huijuan Wang, Raymond A. Kim, Dongxu Sun, Yiwen Gao, Hao Wang, Juanli Zhu & Chao Chen
Pages: 826-835
Published online: 22 Jun 2011
AbstractforEvaluation of the effects of 18 non-synonymous single-nucleotide polymorphisms of CYP450 2C19 on in vitro drug inhibition potential by a fluorescence-based high-throughput assay | Full Text | References | PDF (734.9 KB)
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Erratum

Correction
Erratum
Page: 836
Published online: 20 Jul 2011
CitationforErratum | Full Text | PDF (545.2 KB)
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