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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 8: Drug Metabolism Discussion Group (DMDG) 40th Anniversary
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Research Article

Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism

Eleanor Q. BlatherwickSchool of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, UK
,
Gary J. Van BerkelOrganic and Biological Mass Spectrometry Group, Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA
,
Kathryn PickupClinical Pharmacology and DMPK, AstraZeneca R&D Alderley Park, Alderely Edge, Cheshire, UK
,
Maria K. JohanssonGlobal Distribution Imaging, Clinical Pharmacology and DMPK, AstraZeneca R&D Södertälje, Södertälje, Sweden
,
Marie-Eve BeaudoinDMPK, AstraZeneca Pharmaceuticals, Waltham, MA, USA
,
Roderic O. ColeDMPK, AstraZeneca Pharmaceuticals, Waltham, MA, USA
,
Jennifer M. DayClinical Pharmacology and DMPK, AstraZeneca R&D Charnwood, Loughborough, UK
,
Suzanne IversonGlobal Distribution Imaging, Clinical Pharmacology and DMPK, AstraZeneca R&D Södertälje, Södertälje, Sweden
,
Ian D. WilsonClinical Pharmacology and DMPK, AstraZeneca R&D Alderley Park, Alderely Edge, Cheshire, UK
,
James H. ScrivensSchool of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry, UK
&
Daniel J. WestonClinical Pharmacology and DMPK, AstraZeneca R&D Charnwood, Loughborough, UKCorrespondence[email protected]
 show all
Pages 720-734 | Received 14 Mar 2011, Accepted 09 May 2011, Published online: 14 Jun 2011

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David C. Koomen, Jody C. May & John A. McLean. (2022) Insights and prospects for ion mobility-mass spectrometry in clinical chemistry. Expert Review of Proteomics 19:1, pages 17-31.
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ChristinaR. Ferreira, Lianming Wu, FrederickG. Vogt, EstebanR. Bornancini & R. Graham Cooks. (2014) Fiducial Markers for Distribution of Drug and Excipient on Tablet Surfaces by Multimodal Desorption Electrospray Ionization–Mass Spectrometry (DESI–MS) Imaging. Analytical Letters 47:1, pages 91-101.
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Michael Donegan & Marc Browning. (2012) A REVIEW RECENT DEVELOPMENTS IN SAMPLE IONIZATION INTERFACES USED IN MASS SPECTROMETRY. Journal of Liquid Chromatography & Related Technologies 35:16, pages 2345-2363.
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David Simon & Richard Oleschuk. (2021) The liquid micro junction-surface sampling probe (LMJ-SSP); a versatile ambient mass spectrometry interface. The Analyst.
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Marta Sans, Anna Krieger, Bryan R. Wygant, Kyana Y. Garza, C. Buddie Mullins & Livia S. Eberlin. (2020) Spatially Controlled Molecular Analysis of Biological Samples Using Nanodroplet Arrays and Direct Droplet Aspiration. Journal of the American Society for Mass Spectrometry 31:2, pages 418-428.
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Nicholas H. Oberlies, Sonja L. Knowles, Chiraz Soumia M. Amrine, Diana Kao, Vilmos Kertesz & Huzefa A. Raja. (2019) Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature . Natural Product Reports 36:7, pages 944-959.
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Vilmos Kertesz, Marissa Vavrek, Carol Freddo & Gary J. Van Berkel. (2019) Spatial profiling of stapled α–helical peptide ATSP-7041 in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-HPLC-ESI–MS/MS. International Journal of Mass Spectrometry 437, pages 17-22.
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Li-Xiao Xu, Tian-Tian Wang, Yin-Yin Geng, Wen-Yan Wang, Yin Li, Xiao-Kun Duan, Bin Xu, Charles C. Liu & Wan-Hui Liu. (2017) The direct analysis of drug distribution of rotigotine-loaded microspheres from tissue sections by LESA coupled with tandem mass spectrometry. Analytical and Bioanalytical Chemistry 409:22, pages 5217-5223.
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Xiaohui Chen, Panos Hatsis, Joyce Judge, Upendra A. Argikar, Xiaojun Ren, Jason Sarber, Keith Mansfield, Guiqing Liang, Adam Amaral, Alexandre Catoire, Adam Bentley, Luis Ramos, Paul Moench, Samuel Hintermann, David Carcache, Jim Glick & Jimmy Flarakos. (2016) Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry. Analytical Chemistry 88:23, pages 11813-11820.
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Lars Weidolf & Ian D. Wilson. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development 141 176 .
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Weiqi Chen, Lifei Wang, Gary J. Van Berkel, Vilmos Kertesz & Jinping Gan. (2016) Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Chromatography A 1439, pages 137-143.
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Xin Liu & Amanda B. Hummon. (2015) Mass Spectrometry Imaging of Therapeutics from Animal Models to Three-Dimensional Cell Cultures. Analytical Chemistry 87:19, pages 9508-9519.
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Richard JA Goodwin & Peter JH Webborn. (2015) Future directions of imaging MS in pharmaceutical R&D. Bioanalysis 7:20, pages 2667-2673.
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Vilmos Kertesz, Taylor M. Weiskittel & Gary J. Van Berkel. (2014) An enhanced droplet-based liquid microjunction surface sampling system coupled with HPLC-ESI-MS/MS for spatially resolved analysis. Analytical and Bioanalytical Chemistry 407:8, pages 2117-2125.
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Anna Nilsson, Richard J. A. GoodwinMohammadreza Shariatgorji, Theodosia Vallianatou, Peter J. H. WebbornPer E. Andrén. (2015) Mass Spectrometry Imaging in Drug Development. Analytical Chemistry 87:3, pages 1437-1455.
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Reinaldo Almeida, Zane Berzina, Eva C. Arnspang, Jan Baumgart, Johannes Vogt, Robert Nitsch & Christer S. Ejsing. (2015) Quantitative Spatial Analysis of the Mouse Brain Lipidome by Pressurized Liquid Extraction Surface Analysis. Analytical Chemistry 87:3, pages 1749-1756.
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Jeremy A. Barry, M. Reid Groseclose, Guillaume Robichaud, Stephen Castellino & David C. Muddiman. (2015) Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS. International Journal of Mass Spectrometry 377, pages 448-455.
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Richard J. A. Goodwin, Mohammadreza Shariatgorji & Per E. Andren. 2015. Dopamine Receptor Technologies. Dopamine Receptor Technologies 177 196 .
Guillaume Robichaud, Jeremy A. Barry & David C. Muddiman. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry 1 44 .
Daniel Eikel & Jack D. Henion. 2014. Ambient Ionization Mass Spectrometry. Ambient Ionization Mass Spectrometry 482 495 .
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Joscelyn Sarsby, Nicholas J. Martin, Patricia F. Lalor, Josephine Bunch & Helen J. Cooper. (2014) Top-Down and Bottom-Up Identification of Proteins by Liquid Extraction Surface Analysis Mass Spectrometry of Healthy and Diseased Human Liver Tissue. Journal of the American Society for Mass Spectrometry 25:11, pages 1953-1961.
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Vilmos Kertesz, Nithya Paranthaman, Paul Moench, Alexandre Catoire, Jimmy Flarakos & Gary J Van Berkel. (2014) Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections. Bioanalysis 6:19, pages 2599-2606.
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John G. SwalesJames W. TuckerNicole StrittmatterAnna Nilsson, Diego CobiceMalcolm R. ClenchC. Logan MackayPer E. Andren, Zoltán TakátsPeter J. H. WebbornRichard J. A. Goodwin. (2014) Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis. Analytical Chemistry 86:16, pages 8473-8480.
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Laura Tomlinson, Jens Fuchser, Arne F?tterer, Mark Baumert, David G. Hassall, Andrew West & Peter S. Marshall. (2014) Using a single, high mass resolution mass spectrometry platform to investigate ion suppression effects observed during tissue imaging. Rapid Communications in Mass Spectrometry 28:9, pages 995-1003.
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Eleanor Q. Blatherwick, Camilla I. Svensson, Bruno G. Frenguelli & James H. Scrivens. (2013) Localisation of adenine nucleotides in heat-stabilised mouse brains using ion mobility enabled MALDI imaging. International Journal of Mass Spectrometry 345-347, pages 19-27.
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Gary J. Van Berkel & Vilmos Kertesz. (2013) Continuous-flow liquid microjunction surface sampling probe connected on-line with high-performance liquid chromatography/mass spectrometry for spatially resolved analysis of small molecules and proteins. Rapid Communications in Mass Spectrometry 27:12, pages 1329-1334.
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María Eugenia Monge, Glenn A. Harris, Prabha Dwivedi & Facundo M. Fernández. (2013) Mass Spectrometry: Recent Advances in Direct Open Air Surface Sampling/Ionization. Chemical Reviews 113:4, pages 2269-2308.
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Jusal Quanico, Julien Franck, Claire Dauly, Kerstin Strupat, Jocelyn Dupuy, Robert Day, Michel Salzet, Isabelle Fournier & Maxence Wisztorski. (2013) Development of liquid microjunction extraction strategy for improving protein identification from tissue sections. Journal of Proteomics 79, pages 200-218.
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