Xenobiotica, Volume 41, Issue 8 (2011)

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Xenobiotica, Volume 41, Issue 8 (2011)

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Foreword

The Drug Metabolism Discussion Group in 2011
Pages: 603-604
Published online: 06 Jul 2011
CitationforThe Drug Metabolism Discussion Group in 2011 | Full Text | PDF (505 KB)
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Review Article

Review Article
From definition to implementation: a cross-industry perspective of past, current and future MIST strategies
Angus N.R. Nedderman, Gordon J. Dear, Stephanie North, R. Scott Obach & David Higton
Pages: 605-622
Published online: 29 Mar 2011
AbstractforFrom definition to implementation: a cross-industry perspective of past, current and future MIST strategies | Full Text | References | PDF (901.1 KB)
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Review Article
Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model
Helen E. Cubitt, Karen R. Yeo, Eleanor M. Howgate, Amin Rostami-Hodjegan & Zoe E. Barter
Pages: 623-638
Published online: 24 Mar 2011
AbstractforSources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model | Full Text | References | PDF (1 MB)
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Review Article
Impact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins
Grant T. Generaux, Fiorenza M. Bonomo, Marta Johnson & Kelly M. Mahar Doan
Pages: 639-651
Published online: 22 Mar 2011
AbstractforImpact of SLCO1B1 (OATP1B1) and ABCG2 (BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins | Full Text | References | PDF (759.8 KB)
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Review Article
N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases
Sanna Kaivosaari, Moshe Finel & Mikko Koskinen
Pages: 652-669
Published online: 24 Mar 2011
AbstractforN-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases | Full Text | References | PDF (929.2 KB)
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Review Article
Metabolite identification by mass spectrometry: forty years of evolution
Pat Wright
Pages: 670-686
Published online: 24 Mar 2011
AbstractforMetabolite identification by mass spectrometry: forty years of evolution | Full Text | References | PDF (793.1 KB)
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Review Article
Surgical and pharmacological animal models used in drug metabolism and pharmacokinetics
K.A. Landskroner, P. Hess & A. Treiber
Pages: 687-700
Published online: 13 Apr 2011
AbstractforSurgical and pharmacological animal models used in drug metabolism and pharmacokinetics | Full Text | References | PDF (1,004.4 KB)
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Research Article

Article
Characterization of post-surgical alterations in the bile duct-cannulated rat
Dalila Bachir-Cherif, Denise Blum, Annamaria Braendli-Baiocco, Evelyne Chaput, Gonzalo Christiano Duran Pacheco, Nicholas Flint, Monika Haiker, Jean-Christophe Hoflack, Nicole Justies, Rachel Neff, Volkmar Starke, Guido Steiner, Charles Alexandre Tournillac, Thomas Singer, Geneviève Ubeaud-Séquier & Franz Schuler
Pages: 701-711
Published online: 27 Apr 2011
AbstractforCharacterization of post-surgical alterations in the bile duct-cannulated rat | Full Text | References | PDF (828.1 KB)
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Article
Calcein assay: a high-throughput method to assess P-gp inhibition
H. Glavinas, O. von Richter, K. Vojnits, D. Mehn, I. Wilhelm, T. Nagy, J. Janossy, I. Krizbai, P. Couraud & P. Krajcsi
Pages: 712-719
Published online: 09 Jun 2011
AbstractforCalcein assay: a high-throughput method to assess P-gp inhibition | Full Text | References | PDF (792.9 KB)
  • 766 Views
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Article
Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism
Eleanor Q. Blatherwick, Gary J. Van Berkel, Kathryn Pickup, Maria K. Johansson, Marie-Eve Beaudoin, Roderic O. Cole, Jennifer M. Day, Suzanne Iverson, Ian D. Wilson, James H. Scrivens & Daniel J. Weston
Pages: 720-734
Published online: 14 Jun 2011
AbstractforUtility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism | Full Text | References | PDF (1.2 MB)
  • 490 Views
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Article
Matrix-assisted laser desorption mass spectrometry imaging for the examination of imipramine absorption by Straticell-RHE-EPI/001 an artificial model of the human epidermis
Jennie L. Avery, Andrew McEwen, Bryn Flinders, Simona Francese & Malcolm R. Clench
Pages: 735-742
Published online: 11 Apr 2011
AbstractforMatrix-assisted laser desorption mass spectrometry imaging for the examination of imipramine absorption by Straticell-RHE-EPI/001 an artificial model of the human epidermis | Full Text | References | PDF (1.2 MB)
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