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Xenobiotica
the fate of foreign compounds in biological systems
Volume 41, 2011 - Issue 12
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Animal Pharmacokinetics and Metabolism

Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process

Edna F ChooGenentech Inc, South San Francisco, CA, USA, Departments of Drug Metabolism and PharmacokineticsCorrespondence[email protected]
,
Bruno AlickeCancer Signaling and Translational Oncology
,
Jason BoggsGenentech Inc, South San Francisco, CA, USA, Departments of Drug Metabolism and Pharmacokinetics
,
Vikki DinkelArray BioPharma, Boulder, CO, USA, Departments of Drug Metabolism, Pharmacokinetics and Clinical Pharmacology
,
Stephen GouldCancer Signaling and Translational Oncology
,
Jonas GrinaMedicinal Chemistry
,
Kristina WestCancer Signaling and Translational Oncology
,
Kapil MenghrajaniGenentech Inc, South San Francisco, CA, USA, Departments of Drug Metabolism and Pharmacokinetics
,
Yingqing RanPharmaceutics
,
Joachim RudolphChemistry
&
Steve WenglowskyMedicinal Chemistry
 show all
Pages 1076-1087 | Received 23 Mar 2011, Accepted 04 Jul 2011, Published online: 25 Aug 2011

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Noriaki Ohminato, Miho Nagayasu, Kazuhisa Ozeki, Ryoichi Saitoh, Naomi Ono, Norihito Shibahara, Atsushi Suda & Kouichi Yoshinari. (2021) In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice. Xenobiotica 51:9, pages 968-976.
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Articles from other publishers (5)

Yi Gu, Yang Sai, Jian Wang, Meijing Yu, Guanglin Wang, Li Zhang, Hongcan Ren, Shiming Fan, Yongxin Ren, Weiguo Qing & Weiguo Su. (2019) Preclinical pharmacokinetics, disposition, and translational pharmacokinetic/pharmacodynamic modeling of savolitinib, a novel selective cMet inhibitor. European Journal of Pharmaceutical Sciences 136, pages 104938.
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Fabio Broccatelli, Ignacio Aliagas & Hao Zheng. (2018) Why Decreasing Lipophilicity Alone Is Often Not a Reliable Strategy for Extending IV Half-life. ACS Medicinal Chemistry Letters 9:6, pages 522-527.
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Hala Bakr El-Nassan. (2014) Recent progress in the identification of BRAF inhibitors as anti-cancer agents. European Journal of Medicinal Chemistry 72, pages 170-205.
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Yong Cui, Po-Chang Chiang, Edna F. Choo, Jason Boggs, Joachim Rudolph, Jonas Grina, Steve Wenglowsky & Yingqing Ran. (2013) Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor. International Journal of Pharmaceutics 454:1, pages 241-248.
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Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman, Ravi M. Shanker, William N. Charman, Colin W. Pouton & Christopher J. H. Porter. (2013) Strategies to Address Low Drug Solubility in Discovery and Development. Pharmacological Reviews 65:1, pages 315-499.
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