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Hua Sun, Xiaotong Zhou & Baojian Wu. (2015) Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells. Xenobiotica 45:11, pages 945-953.
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Dong Gui Hu, Robyn Meech, Ross A. McKinnon & Peter I. Mackenzie. (2014) Transcriptional regulation of human UDP-glucuronosyltransferase genes. Drug Metabolism Reviews 46:4, pages 421-458.
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Li Di. (2014) The role of drug metabolizing enzymes in clearance. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 379-393.
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Articles from other publishers (34)
Jiapeng Li, Logan S. Smith & Hao-Jie Zhu. (2021) Data-independent acquisition (DIA): An emerging proteomics technology for analysis of drug-metabolizing enzymes and transporters. Drug Discovery Today: Technologies 39, pages 49-56.
Crossref
Crossref
Dong Gui Hu, Shashikanth Marri, Peter I. Mackenzie, Julie-Ann Hulin, Ross A. McKinnon & Robyn Meech. (2021) The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes. Cancers 13:17, pages 4491.
Crossref
Crossref
Christoph Wenzel, Marek Drozdzik & Stefan Oswald. (2021) Mass spectrometry-based targeted proteomics method for the quantification of clinically relevant drug metabolizing enzymes in human specimens. Journal of Chromatography B 1180, pages 122891.
Crossref
Crossref
Jin Zhou, Upendra A. Argikar & John O. Miners. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
301
338
.
Luca Docci, Florian Klammers, Aynur Ekiciler, Birgit Molitor, Kenichi Umehara, Isabelle Walter, Stephan Krähenbühl, Neil Parrott & Stephen Fowler. (2020) In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes. The AAPS Journal 22:6.
Crossref
Crossref
Haiman Xu, Min Chen, Fangjun Yu, Tianpeng Zhang & Baojian Wu. (2020)
Circadian Clock Component Rev-erb
α
Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice
. Drug Metabolism and Disposition 48:8, pages 681-689.
Crossref
Crossref
Jiapeng Li & Hao-Jie Zhu. (2020) Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)-Based Proteomics of Drug-Metabolizing Enzymes and Transporters. Molecules 25:11, pages 2718.
Crossref
Crossref
Haeyoung Zhang, Abdul Basit & Bhagwat Prasad. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
359
385
.
Eman El-Khateeb, Areti-Maria Vasilogianni, Sarah Alrubia, Zubida M. Al-Majdoub, Narciso Couto, Martyn Howard, Jill Barber, Amin Rostami-Hodjegan & Brahim Achour. (2019) Quantitative mass spectrometry-based proteomics in the era of model-informed drug development: Applications in translational pharmacology and recommendations for best practice. Pharmacology & Therapeutics 203, pages 107397.
Crossref
Crossref
Bing He, Jian Shi, Xinwen Wang, Hui Jiang & Hao-Jie Zhu. (2019) Label-free absolute protein quantification with data-independent acquisition. Journal of Proteomics 200, pages 51-59.
Crossref
Crossref
Justine Badée, Stephen Fowler, Saskia N. de Wildt, Abby C. Collier, Stephan Schmidt & Neil Parrott. (2018) The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling. Clinical Pharmacokinetics 58:2, pages 189-211.
Crossref
Crossref
Xia Lv, Jian-Bin Zhang, Jie Hou, Tong-Yi Dou, Guang-Bo Ge, Wen-Zhong Hu & Ling Yang. (2019) Chemical Probes for Human UDP-Glucuronosyltransferases: A Comprehensive Review. Biotechnology Journal 14:1, pages 1800002.
Crossref
Crossref
Chen Xu, Jie Gao, Hai-Feng Zhang, Na Gao, Yuan-yuan Guo, Yan Fang, Qiang Wen & Hai-Ling Qiao. (2018) Content and Activities of UGT2B7 in Human Liver In Vitro and Predicted In Vivo: A Bottom-Up Approach. Drug Metabolism and Disposition 46:9, pages 1351-1359.
Crossref
Crossref
Brahim Achour, Alyssa Dantonio, Mark Niosi, Jonathan J. Novak, John K. Fallon, Jill Barber, Philip C. Smith, Amin Rostami-Hodjegan & Theunis C. Goosen. (2017) Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity. Drug Metabolism and Disposition 45:10, pages 1102-1112.
Crossref
Crossref
Jiamei Chen, Haihui Zheng, Sijing Zeng, Cong Xie, Xiaoyan Li, Tongmeng Yan, Xia Gong, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, Lijun Zhu & Zhongqiu Liu. (2017) Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice. Molecular Pharmaceutics 14:9, pages 2967-2976.
Crossref
Crossref
Anthony Hardy, Diane Benford, Thorhallur Halldorsson, Michael John Jeger, Helle Katrine Knutsen, Simon More, Hanspeter Naegeli, Hubert Noteborn, Colin Ockleford, Antonia Ricci, Guido Rychen, Josef R Schlatter, Vittorio Silano, Roland Solecki, Dominique Turck, Jean‐Louis Bresson, Birgit Dusemund, Ursula Gundert‐Remy, Mathilde Kersting, Claude Lambré, André Penninks, Angelika Tritscher, Ine Waalkens‐Berendsen, Ruud Woutersen, Davide Arcella, Daniele Court Marques, Jean‐Lou Dorne, George EN Kass & Alicja Mortensen. (2017) Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age. EFSA Journal 15:5.
Crossref
Crossref
D. F. Dluzen, A. K. Sutliff, G. Chen, C. J. W. Watson, F. T. Ishmael & P. Lazarus. (2016) Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines. Journal of Pharmacology and Experimental Therapeutics 359:1, pages 182-193.
Crossref
Crossref
T. Bohnert, A. Patel, I. Templeton, Y. Chen, C. Lu, G. Lai, L. Leung, S. Tse, H. J. Einolf, Y.-H. Wang, M. Sinz, R. Stearns, R. Walsky, W. Geng, S. Sudsakorn, D. Moore, L. He, J. Wahlstrom, J. Keirns, R. Narayanan, D. Lang & X. Yang. (2016) Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions--an Industry Perspective. Drug Metabolism and Disposition 44:8, pages 1399-1423.
Crossref
Crossref
J. Matthew Hutzler & Michael A. Zientek. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics
79
130
.
Guillaume Margaillan, Michèle Rouleau, John K. Fallon, Patrick Caron, Lyne Villeneuve, Véronique Turcotte, Philip C. Smith, Melanie S. Joy & Chantal Guillemette. (2015) Quantitative Profiling of Human Renal UDP-glucuronosyltransferases and Glucuronidation Activity: A Comparison of Normal and Tumoral Kidney Tissues. Drug Metabolism and Disposition 43:4, pages 611-619.
Crossref
Crossref
Tongmeng Yan, Song Gao, Xiaojuan Peng, Jian Shi, Cong Xie, Qiang Li, Linlin Lu, Ying Wang, Fuyuan Zhou, Zhongqiu Liu & Ming Hu. (2014) Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method. Pharmaceutical Research 32:3, pages 1141-1157.
Crossref
Crossref
Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi & Miki Nakajima. (2015) A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development. Drug Metabolism and Pharmacokinetics 30:1, pages 30-51.
Crossref
Crossref
Michael A. Zientek & Kuresh Youdim. (2015) Reaction Phenotyping: Advances in the Experimental Strategies Used to Characterize the Contribution of Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 43:1, pages 163-181.
Crossref
Crossref
Huanhuan Wang, Haifeng Zhang, Jiabin Li, Junying Wei, Rui Zhai, Bo Peng, Hailing Qiao, Yangjun Zhang & Xiaohong Qian. (2015) A new calibration curve calculation method for absolute quantification of drug metabolizing enzymes in human liver microsomes by stable isotope dilution mass spectrometry. Analytical Methods 7:14, pages 5934-5941.
Crossref
Crossref
C. Gröer, D. Busch, M. Patrzyk, K. Beyer, A. Busemann, C.D. Heidecke, M. Drozdzik, W. Siegmund & S. Oswald. (2014) Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics. Journal of Pharmaceutical and Biomedical Analysis 100, pages 393-401.
Crossref
Crossref
Brahim Achour, Amin Rostami-Hodjegan & Jill Barber. (2014) Protein expression of various hepatic uridine 5′-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: a meta-analysis. Biopharmaceutics & Drug Disposition 35:6, pages 353-361.
Crossref
Crossref
Ahmad Al Ali, David Touboul, Jean-Pierre Le Caër, Isabelle Schmitz-Afonso, Jean-Pierre Flinois, Catherine Marchetti, Isabelle De Waziers, Alain Brunelle, Olivier Laprévote & Philippe Beaune. (2014) Optimization and validation of a label-free MRM method for the quantification of cytochrome P450 isoforms in biological samples. Analytical and Bioanalytical Chemistry 406:20, pages 4861-4874.
Crossref
Crossref
Yuichiro Sato, Masanori Nagata, Kazuhiro Tetsuka, Kouichi Tamura, Aiji Miyashita, Akio Kawamura & Takashi Usui. (2014) Optimized Methods for Targeted Peptide-Based Quantification of Human Uridine 5′-Diphosphate-Glucuronosyltransferases in Biological Specimens Using Liquid Chromatography–Tandem Mass Spectrometry. Drug Metabolism and Disposition 42:5, pages 885-889.
Crossref
Crossref
Brahim Achour, Matthew R. Russell, Jill Barber & Amin Rostami-Hodjegan. (2014) Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics. Drug Metabolism and Disposition 42:4, pages 500-510.
Crossref
Crossref
Rong Shi, Yuanyuan Yang, Jie Zhong, Tianming Wang & Yueming Ma. (2014) Validated assay for the evaluation of multiple glucuronidation activities in human liver microsomes via liquid chromatography-tandem mass spectrometry. RSC Adv. 4:99, pages 56132-56138.
Crossref
Crossref
Beibei Xu, Song Gao, Baojian Wu, Taijun Yin & Ming Hu. (2014) Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC–MS/MS method determines its turnover number and correlates with its glucuronidation activities. Journal of Pharmaceutical and Biomedical Analysis 88, pages 180-190.
Crossref
Crossref
Jin Zhou & John O. Miners. 2014. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism
203
228
.
John K. Fallon, Hendrik Neubert, Ruth Hyland, Theunis C. Goosen & Philip C. Smith. (2013) Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring. Journal of Proteome Research 12:10, pages 4402-4413.
Crossref
Crossref
Cexiong Fu, Li Di, Xiaogang Han, Cathy Soderstrom, Mark Snyder, Matthew D. Troutman, R. Scott Obach & Hui Zhang. (2013) Aldehyde Oxidase 1 (AOX1) in Human Liver Cytosols: Quantitative Characterization of AOX1 Expression Level and Activity Relationship. Drug Metabolism and Disposition 41:10, pages 1797-1804.
Crossref
Crossref