Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities

References

• Alterman MA, Kornilayev B, Duzhak T, Yakovlev D. (2005). Quantitative analysis of cytochrome p450 isozymes by means of unique isozyme-specific tryptic peptides: a proteomic approach. Drug Metab Dispos 33:1399–1407.
   PubMed Web of Science ®Google Scholar
• Court MH. (2005). Isoform-selective probe substrates forin vitrostudies of human UDP-glucuronosyltransferases. Meth Enzymol 400:104–116.
   PubMed Web of Science ®Google Scholar
• Court MH, Krishnaswamy S, Hao Q, Duan SX, Patten CJ, Von Moltke LL, Greenblatt DJ. (2003). Evaluation of 3′-azido-3′-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism. Drug Metab Dispos 31:1125–1133.
   PubMed Web of Science ®Google Scholar
• Fallon JK, Harbourt DE, Maleki SH, Kessler FK, Ritter JK, Smith PC. (2008). Absolute quantification of human uridine-diphosphate glucuronosyl transferase (UGT) enzyme isoforms 1A1 and 1A6 by tandem LC-MS. Drug Metab Lett 2:210–222.
   PubMedGoogle Scholar
• Harbourt DE, Fallon JK, Ito S, Baba T, Ritter JK, Glish GL, Smith PC. (2012). Quantification of Human Uridine-Diphosphate Glucuronosyl Transferase 1A Isoforms in Liver, Intestine, and Kidney Using Nanobore Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem 84:98–105.
   PubMed Web of Science ®Google Scholar
• Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine Y, Uchida Y, Ito S, Terasaki T. (2008). Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm Res 25:1469–1483.
   PubMed Web of Science ®Google Scholar
• Kawakami H, Ohtsuki S, Kamiie J, Suzuki T, Abe T, Terasaki T. (2011). Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection. J Pharm Sci 100:341–352.
   PubMed Web of Science ®Google Scholar
• Langenfeld E, Zanger UM, Jung K, Meyer HE, Marcus K. (2009). Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver. Proteomics 9:2313–2323.
   PubMed Web of Science ®Google Scholar
• Li N, Nemirovskiy OV, Zhang Y, Yuan H, Mo J, Ji C, Zhang B, Brayman TG, Lepsy C, Heath TG, Lai Y. (2008). Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry. Anal Biochem 380:211–222.
   PubMed Web of Science ®Google Scholar
• Li N, Palandra J, Nemirovskiy OV, Lai Y. (2009). LC-MS/MS mediated absolute quantification and comparison of bile salt export pump and breast cancer resistance protein in livers and hepatocytes across species. Anal Chem 81:2251–2259.
   PubMed Web of Science ®Google Scholar
• Li N, Singh P, Mandrell KM, Lai Y. (2010). Improved extrapolation of hepatobiliary clearance fromin vitrosandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters. Mol Pharm 7:630–641.
   PubMed Web of Science ®Google Scholar
• Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW. (2005). Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics 15:677–685.
   PubMed Web of Science ®Google Scholar
• Miliotis T, Ali L, Palm JE, Lundqvist AJ, Ahnoff M, Andersson TB, Hilgendorf C. (2011). Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function. Drug Metab Dispos 39:2440–2449.
   PubMed Web of Science ®Google Scholar
• Milne AM, Burchell B, Coughtrie MW. (2011). A novel method for the immunoquantification of UDP-glucuronosyltransferases in human tissue. Drug Metab Dispos 39:2258–2263.
   PubMed Web of Science ®Google Scholar
• Ohno S, Kawana K, Nakajin S. (2008). Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. Drug Metab Dispos 36:688–694.
   PubMed Web of Science ®Google Scholar
• Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Saito A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, Ebner T, Terasaki T. (2012). Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos 40:83–92.
   PubMed Web of Science ®Google Scholar
• Sakamoto A, Matsumaru T, Ishiguro N, Schaefer O, Ohtsuki S, Inoue T, Kawakami H, Terasaki T. (2011). Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography. J Pharm Sci 100:4037–4043.
   PubMedGoogle Scholar
• Schaefer O, Ohtsuki S, Kawakami H, Inoue T, Liehner S, Saito A, Sakamoto A, Ishiguro N, Matsumaru T, Terasaki T, Ebner T. (2012). Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes. Drug Metab Dispos 40:93–103.
   PubMed Web of Science ®Google Scholar
• Seibert C, Davidson BR, Fuller BJ, Patterson LH, Griffiths WJ, Wang Y. (2009). Multiple-approaches to the identification and quantification of cytochromes P450 in human liver tissue by mass spectrometry. J Proteome Res 8:1672–1681.
   PubMed Web of Science ®Google Scholar
• Tukey RH, Strassburg CP. (2000). Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581–616.
   PubMed Web of Science ®Google Scholar
• Wells PG, Mackenzie PI, Chowdhury JR, Guillemette C, Gregory PA, Ishii Y, Hansen AJ, Kessler FK, Kim PM, Chowdhury NR, Ritter JK. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. Drug Metab Dispos 32:281–290.
   PubMed Web of Science ®Google Scholar
• Williamson BL, Purkayastha S, Hunter CL, Nuwaysir L, Hill J, Easterwood L, Hill J. (2011). Quantitative protein determination for CYP induction via LC-MS/MS. Proteomics 11:33–41.
   PubMedGoogle Scholar
• Zhang Y, Li N, Brown PW, Ozer JS, Lai Y. (2011). Liquid chromatography/tandem mass spectrometry based targeted proteomics quantification of P-glycoprotein in various biological samples. Rapid Commun Mass Spectrom 25:1715–1724.
   PubMed Web of Science ®Google Scholar