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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 2
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Animal Pharmacokinetics and Metabolism

Absorption of TAK-491, a new angiotensin II receptor antagonist, in animals

Naohiro KawaguchiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, JapanCorrespondence[email protected]
,
Takuya EbiharaDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
,
Toshiyuki TakeuchiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
,
Akio MorohashiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
,
Hitomi YamasakiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
,
Yoshihiko TagawaDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
,
Junzo TakahashiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
,
Takahiro KondoDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
&
Satoru AsahiDrug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Japan
 show all
Pages 182-192 | Received 26 Apr 2012, Accepted 29 Jun 2012, Published online: 07 Aug 2012

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Hidetaka Kamimura, Shotaro Uehara, Nao Yoneda & Hiroshi Suemizu. (2023) Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers. Xenobiotica 53:8-9, pages 523-535.
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Articles from other publishers (6)

Yuanzhi He, Wei Zhang, Tao Guo, Guoqing Zhang, Wei Qin, Liu Zhang, Caifen Wang, Weifeng Zhu, Ming Yang, Xiaoxiao Hu, Vikramjeet Singh, Li Wu, Ruxandra Gref & Jiwen Zhang. (2019) Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan. Acta Pharmaceutica Sinica B 9:1, pages 97-106.
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Santosh Kumar Puttrevu, Rachumallu Ramakrishna, Manisha Bhateria, Moon Jain, Kashif Hanif & Rabi Sankar Bhatta. (2017) Pharmacokinetic-pharmacodynamic modeling of the antihypertensive interaction between azilsartan medoxomil and chlorthalidone in spontaneously hypertensive rats. Naunyn-Schmiedeberg's Archives of Pharmacology 390:5, pages 457-470.
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Yoji Kuze, Akifumi Kogame, Fumihiro Jinno, Takahiro Kondo & Satoru Asahi. (2015) Development, validation and application of the liquid chromatography tandem mass spectrometry method for simultaneous quantification of azilsartan medoxomil (TAK-491), azilsartan (TAK-536), and its 2 metabolites in human plasma. Journal of Chromatography B 1001, pages 174-181.
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Cheng Gong, Junfeng Wang, Yinghua Sun, Dawei Ding, Lu Zhong, Meng Zhu, Jin Sun & Xiangrong Zhang. (2015) UPLC–MS/MS for the determination of azilsartan in beagle dog plasma and its application in a pharmacokinetics study. Asian Journal of Pharmaceutical Sciences 10:3, pages 247-253.
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Rachumallu Ramakrishna, Santosh kumar Puttrevu, Manisha Bhateria, Veenu Bala, Vishnu L. Sharma & Rabi Sankar Bhatta. (2015) Simultaneous determination of azilsartan and chlorthalidone in rat and human plasma by liquid chromatography-electrospray tandem mass spectrometry. Journal of Chromatography B 990, pages 185-197.
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Tomoko Ishizuka, Yasushi Yoshigae, Nobuyuki Murayama & Takashi Izumi. (2013) Different Hydrolases Involved in Bioactivation of Prodrug-Type Angiotensin Receptor Blockers: Carboxymethylenebutenolidase and Carboxylesterase 1. Drug Metabolism and Disposition 41:11, pages 1888-1895.
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