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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 3
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General Xenobiochemistry

Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect

Ling LiDepartments of Drug Metabolism, Pharmacokinetics, Toxicology and Pathology, Lexicon Pharmaceuticals, Inc., The Woodlands, TX, USACorrespondence[email protected]
,
Amr NouraldeenDepartments of Drug Metabolism, Pharmacokinetics, Toxicology and Pathology, Lexicon Pharmaceuticals, Inc., The Woodlands, TX, USA
&
Alan G. E. WilsonDepartments of Drug Metabolism, Pharmacokinetics, Toxicology and Pathology, Lexicon Pharmaceuticals, Inc., The Woodlands, TX, USA
Pages 253-262 | Received 10 Apr 2012, Accepted 13 Jul 2012, Published online: 28 Aug 2012

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Simon J. Carter, Alex S. Ferecskó, Lloyd King, Karelle Ménochet, Ted Parton & Michael J. Chappell. (2020) A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method. Xenobiotica 50:4, pages 415-426.
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Bo Feng, Manthena V Varma, Chester Costales, Hui Zhang & Larry Tremaine. (2014) In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery. Expert Opinion on Drug Discovery 9:8, pages 873-890.
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Articles from other publishers (8)

Simon J. Carter, Bhavik Chouhan, Pradeep Sharma & Michael J. Chappell. (2020) Prediction of Clinical Transporter‐Mediated Drug–Drug Interactions via Comeasurement of Pitavastatin and Eltrombopag in Human Hepatocyte Models. CPT: Pharmacometrics & Systems Pharmacology 9:4, pages 211-221.
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Julian Selano, Vicki Richardson, John Washington & Chris Mazur. (2019) Characterization of non-radiolabeled Thyroxine (T4) uptake in cryopreserved rat hepatocyte suspensions: Pharmacokinetic implications for PFOA and PFOS chemical exposure. Toxicology in Vitro 58, pages 230-238.
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T. I. Arefieva, A. Yu. Filatova, A. V. Potekhina & A. M. Shchinova. (2018) Immunotropic Effects and Proposed Mechanism of Action for 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors (Statins). Biochemistry (Moscow) 83:8, pages 874-889.
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Han Song, Yuli Wang, Lu Zhang, Liping Tian, Jun Luo, Na Zhao, Yajie Han, Feilang Zhao, Xue Ying & Yingchun Li. (2017) An ultrasensitive and selective electrochemical sensor for determination of estrone 3-sulfate sodium salt based on molecularly imprinted polymer modified carbon paste electrode. Analytical and Bioanalytical Chemistry 409:27, pages 6509-6519.
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Eleni Kotsampasakou, Sylvia E. Escher & Gerhard F. Ecker. (2017) Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case. European Journal of Pharmaceutical Sciences 100, pages 9-16.
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Hugues Chanteux, Ludovicus Staelens, Valérie Mancel, Brigitte Gerin, David Boucaut, Chandra Prakash & Jean-Marie Nicolas. (2015) Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α 4 β 1/ α 4 β 7 Integrin Antagonist . Drug Metabolism and Disposition 43:9, pages 1381-1391.
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H. Shen, H. Su, T. Liu, M. Yao, G. Mintier, L. Li, R. M. Fancher, R. Iyer, P. Marathe, Y. Lai & A. D. Rodrigues. (2015) Evaluation of Rosuvastatin as an Organic Anion Transporting Polypeptide (OATP) Probe Substrate: In Vitro Transport and In Vivo Disposition in Cynomolgus Monkeys. Journal of Pharmacology and Experimental Therapeutics 353:2, pages 380-391.
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Patrick T. Ronaldson & Thomas P. Davis. (2013) Targeted Drug Delivery to Treat Pain and Cerebral Hypoxia. Pharmacological Reviews 65:1, pages 291-314.
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