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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 12
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General Xenobiochemistry

Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans

Christopher R. GibsonPharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM), Merck Research Laboratories West Point, PA (CRG, PL, CM, CW, MS) and Rahway, NJ (DNG)USACorrespondence[email protected]
,
Ping LuPharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM), Merck Research Laboratories West Point, PA (CRG, PL, CM, CW, MS) and Rahway, NJ (DNG)USA
,
Cheri MaciolekPharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM), Merck Research Laboratories West Point, PA (CRG, PL, CM, CW, MS) and Rahway, NJ (DNG)USA
,
Christen WudarskiPharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM), Merck Research Laboratories West Point, PA (CRG, PL, CM, CW, MS) and Rahway, NJ (DNG)USA
,
Zoe BarterSimCYP Ltd. (now Certara) SheffieldUK
,
Karen Rowland-YeoSimCYP Ltd. (now Certara) SheffieldUK
,
Mark StrohPharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM), Merck Research Laboratories West Point, PA (CRG, PL, CM, CW, MS) and Rahway, NJ (DNG)USA
,
Eseng LaiDepartment of Clinical Pharmacology, Merck Research Laboratories Rahway, NJUSA
&
Deborah A. Nicoll-GriffithPharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM), Merck Research Laboratories West Point, PA (CRG, PL, CM, CW, MS) and Rahway, NJ (DNG)USA
 show all
Pages 1027-1036 | Received 22 Jan 2013, Accepted 28 Mar 2013, Published online: 03 May 2013

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Li Di. (2017) Reaction phenotyping to assess victim drug-drug interaction risks. Expert Opinion on Drug Discovery 12:11, pages 1105-1115.
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Christina M. Street, Zhaohui Zhu, Moshe Finel & Michael H. Court. (2017) Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms. Xenobiotica 47:1, pages 1-10.
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Articles from other publishers (16)

Barbara Wiśniowska, Susanne Linke, Sebastian Polak, Zofia Bielecka, Andreas Luch & Ralph Pirow. (2023) Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paper. Toxicology and Applied Pharmacology 459, pages 116357.
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Tomoyo Honda, Wataru Obuchi, Yumi Nishiya, Takahiro Shibayama, Kengo Watanabe & Nobuaki Watanabe. (2022) Estimation of fraction of drug metabolism by a single UDP‐glucuronosyl transferase enzyme using relative expression factor. Biopharmaceutics & Drug Disposition 43:5, pages 213-217.
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Päivi Taavitsainen, Olaf Prien, Marja Kähkönen, Michael Niehues, Timo Korjamo, Karsten Denner, Pirjo Nykänen, Annamari Vuorela, Natalia A. Jungmann, Clemens-Jeremias von Bühler, Mikko Koskinen, Christian Zurth & Hille Gieschen. (2021) Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans. Drug Metabolism and Disposition 49:6, pages 420-433.
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David Busse, Sara Leandersson, Sara Amberntsson, Malin Darnell & Constanze Hilgendorf. (2020) Industrial Approach to Determine the Relative Contribution of Seven Major UGT Isoforms to Hepatic Glucuronidation. Journal of Pharmaceutical Sciences 109:7, pages 2309-2320.
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Ravindra Varma Alluri & Manthena V.S. Varma. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters 609 631 .
Justine Badée, Stephen Fowler, Saskia N. de Wildt, Abby C. Collier, Stephan Schmidt & Neil Parrott. (2018) The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling. Clinical Pharmacokinetics 58:2, pages 189-211.
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Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C. Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O. Cameron & Amit S. Kalgutkar. (2018) 6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1 H -Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β -Estradiol . Drug Metabolism and Disposition 46:12, pages 1836-1846.
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Upendra A. Argikar, Philip M. Potter, J. Matthew Hutzler & Punit H. Marathe. (2016) Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance. The AAPS Journal 18:6, pages 1391-1405.
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Daniel Scotcher, Christopher Jones, Maria Posada, Aleksandra Galetin & Amin Rostami-Hodjegan. (2016) Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation. The AAPS Journal 18:5, pages 1082-1094.
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T. Bohnert, A. Patel, I. Templeton, Y. Chen, C. Lu, G. Lai, L. Leung, S. Tse, H. J. Einolf, Y.-H. Wang, M. Sinz, R. Stearns, R. Walsky, W. Geng, S. Sudsakorn, D. Moore, L. He, J. Wahlstrom, J. Keirns, R. Narayanan, D. Lang & X. Yang. (2016) Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions--an Industry Perspective. Drug Metabolism and Disposition 44:8, pages 1399-1423.
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William Brian, Larry M Tremaine, Million Arefayene, Ruben de Kanter, Raymond Evers, Yingying Guo, James Kalabus, Wen Lin, Cho-Ming Loi & Guangqing Xiao. (2016) Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG. Pharmacogenomics 17:6, pages 615-631.
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J. Matthew Hutzler & Michael A. Zientek. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 79 130 .
Yoichi Naritomi, Fumihiro Nakamori, Takako Furukawa & Kenji Tabata. (2015) Prediction of hepatic and intestinal glucuronidation using in vitro–in vivo extrapolation. Drug Metabolism and Pharmacokinetics 30:1, pages 21-29.
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Michael A. Zientek & Kuresh Youdim. (2015) Reaction Phenotyping: Advances in the Experimental Strategies Used to Characterize the Contribution of Drug-Metabolizing Enzymes. Drug Metabolism and Disposition 43:1, pages 163-181.
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Barbara A. Wetmore, Brittany Allen, Harvey J. ClewellIIIIII, Timothy Parker, John F. Wambaugh, Lisa M. Almond, Mark A. Sochaski & Russell S. Thomas. (2014) Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing. Toxicological Sciences 142:1, pages 210-224.
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Li Di, Bo Feng, Theunis C. Goosen, Yurong Lai, Stefanus J. Steyn, Manthena V. Varma & R. Scott Obach. (2013) A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development. Drug Metabolism and Disposition 41:12, pages 1975-1993.
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