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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 3
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General Xenobiochemistry

Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions

Ramakrishna NirogiDiscovery ResearchCorrespondence[email protected]
,
Vishwottam KandikerePharmacokinetics and Drug Metabolism, Suven Life Sciences Ltd Serene Chambers, Banjara Hills, HyderabadIndia
,
Raghava Choudary PalacharlaPharmacokinetics and Drug Metabolism, Suven Life Sciences Ltd Serene Chambers, Banjara Hills, HyderabadIndia
,
Gopinadh BhyrapuneniPharmacokinetics and Drug Metabolism, Suven Life Sciences Ltd Serene Chambers, Banjara Hills, HyderabadIndia
,
Vijaya Bhargava KanamarlapudiPharmacokinetics and Drug Metabolism, Suven Life Sciences Ltd Serene Chambers, Banjara Hills, HyderabadIndia
,
Ranjith Kumar PonnamaneniPharmacokinetics and Drug Metabolism, Suven Life Sciences Ltd Serene Chambers, Banjara Hills, HyderabadIndia
&
Arun Kumar ManoharanPharmacokinetics and Drug Metabolism, Suven Life Sciences Ltd Serene Chambers, Banjara Hills, HyderabadIndia
 show all
Pages 197-204 | Received 06 May 2013, Accepted 23 Jun 2013, Published online: 24 Oct 2013

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Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu. (2021) Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica 51:5, pages 582-589.
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Christine Beedham. (2020) Aldehyde oxidase; new approaches to old problems. Xenobiotica 50:1, pages 34-50.
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Narges Cheshmazar, Siavoush Dastmalchi, Mineko Terao, Enrico Garattini & Maryam Hamzeh-Mivehroud. (2019) Aldehyde oxidase at the crossroad of metabolism and preclinical screening. Drug Metabolism Reviews 51:4, pages 428-452.
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Ramakrishna Nirogi, Raghava Choudary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Surya Rao Srikakolapu, Ilayaraja Kalaikadhiban, Rajesh Kumar Boggavarapu, Ranjith Kumar Ponnamaneni, Devender Reddy Ajjala & Gopinadh Bhyrapuneni. (2015) Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays. Xenobiotica 45:2, pages 95-106.
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Dayanidhi Behera, Rambabu Pattem & Girish Gudi. (2014) Effect of commonly used organic solvents on Aldehyde oxidase-mediated Vanillin, Phthalazine and Methotrexate oxidation in human, rat and mouse liver subcellular fractions. Xenobiotica 44:8, pages 722-733.
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Articles from other publishers (17)

Anam Hammid, John K. Fallon, Kati-Sisko Vellonen, Toni Lassila, Mika Reinisalo, Arto Urtti, Francisco Gonzalez, Ari Tolonen, Philip C. Smith & Paavo Honkakoski. (2023) Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues. European Journal of Pharmaceutical Sciences, pages 106603.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Xiaoyan Pang, Chongzhuang Tang, Runcong Guo & Xiaoyan Chen. (2022) Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity. Pharmacology & Therapeutics 233, pages 108020.
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Somaieh Soltani, Somayeh Hallaj-Nezhadi & Mohammad Reza Rashidi. (2021) A comprehensive review of in silico approaches for the prediction and modulation of aldehyde oxidase-mediated drug metabolism: The current features, challenges and future perspectives. European Journal of Medicinal Chemistry 222, pages 113559.
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Lei Zhou, Xiao-yan Pang, Xiang-yu Hou, Lu Liu, Zi-tao Guo & Xiao-yan Chen. (2020) Nimesulide increases the aldehyde oxidase activity of humans and rats. Acta Pharmacologica Sinica 41:6, pages 843-851.
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Anima Ghosal. 2020. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters 237 271 .
Nenad Manevski, Lloyd King, William R. Pitt, Fabien Lecomte & Francesca Toselli. (2019) Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. Journal of Medicinal Chemistry 62:24, pages 10955-10994.
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Xin Yang, Nathaniel Johnson & Li Di. (2019) Evaluation of Cytochrome P450 Selectivity for Hydralazine as an Aldehyde Oxidase Inhibitor for Reaction Phenotyping. Journal of Pharmaceutical Sciences 108:4, pages 1627-1630.
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Farnaz Deris-Abdolahpour, Lida Abdolalipouran-Sadegh, Siavoush Dastmalchi, Maryam Hamzeh-Mivehroud, Omid Zarei, Gholamreza Dehgan & Mohammad-Reza Rashidi. (2018) Effects of Phenothiazines on Aldehyde Oxidase Activity Towards Aldehydes and N-Heterocycles: an In Vitro and In Silico Study. European Journal of Drug Metabolism and Pharmacokinetics 44:2, pages 275-286.
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Rima Obeid, Juergen Geisel & Wilfred A. Nix. (2019) 4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores. Diagnostics 9:1, pages 28.
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Jim Zheng, Yan Xin, Jingyu Zhang, Raju Subramanian, Bernard P. Murray, J. Andrew Whitney, Matthew R. Warr, John Ling, Lisa Moorehead, Ellen Kwan, Jeffrey Hemenway, Bill J. Smith & Jeffrey A. Silverman. (2018) Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite—Resolution for Clinical Development. Drug Metabolism and Disposition 46:3, pages 237-247.
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Raghava Choudary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Ranjith Kumar Ponnamaneni, Nagasurya Prakash Padala, Rajesh Kumar Boggavarapu, Gopinadh Bhyrapuneni, Devender Reddy Ajjala & Ramakrishna Nirogi. (2017) Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance. European Journal of Pharmaceutical Sciences 101, pages 80-89.
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Upendra A. Argikar, Philip M. Potter, J. Matthew Hutzler & Punit H. Marathe. (2016) Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance. The AAPS Journal 18:6, pages 1391-1405.
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R. D. Crouch, R. D. Morrison, F. W. Byers, C. W. Lindsley, K. A. Emmitte & J. S. Daniels. (2016) Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity. Drug Metabolism and Disposition 44:8, pages 1296-1303.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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Lei Zhou, Xiaoyan Pang, Cen Xie, Dafang Zhong & Xiaoyan Chen. (2015) Chemical and Enzymatic Transformations of Nimesulide to GSH Conjugates through Reductive and Oxidative Mechanisms. Chemical Research in Toxicology 28:12, pages 2267-2277.
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J. Matthew Hutzler & Michael A. Zientek. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 79 130 .

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