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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 3
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Animal Pharmacokinetics and Metabolism

Pre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate LaSOM 65 in rats

Bruna G. S. TorresPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre RSBrazil
,
Flávia De Toni UchôaCentro Bioanalítico de Medicamentos (CBIM), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul Porto Alegre, RSBrazil
,
Maiara C. PigattoPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre RSBrazil
,
Francine J. AzeredoPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre RSBrazil
,
Sandra E. HaasPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre RSBrazil
,
Eliane DallegraveDepartamento de Ciências Básicas da Saúde, Fundação Universidade Federal de Ciências da Saúde de Porto Alegre Porto Alegre, RSBrazil
,
Rômulo F. S. CantoPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre RSBrazil;Laboratório de Síntese Orgânica e Medicinal (LaSOM), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul Porto Alegre, RSBrazil
,
Vera L. Eifler-LimaPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre RSBrazil;Laboratório de Síntese Orgânica e Medicinal (LaSOM), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul Porto Alegre, RSBrazil
&
Teresa Dalla CostaPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre RSBrazil;Centro Bioanalítico de Medicamentos (CBIM), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul Porto Alegre, RSBrazilCorrespondence[email protected]
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Pages 254-263 | Received 06 May 2013, Accepted 01 Jul 2013, Published online: 12 Aug 2013

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Barbra Sanches Moraes, Francine Johansson Azeredo, Jessica Cristina Izoton, Marina Amaral, Eliezer de Jesus Barreiro, Rodrigo José Freddo, Teresa Dalla Costa, Lídia Moreira Lima & Sandra Elisa Haas. (2018) Leishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution. Xenobiotica 48:12, pages 1258-1267.
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Articles from other publishers (5)

Luciano Porto Kagami, Itamar Luís Gonçalves, Álisson Coldebella da Silva, Aline Castro Silva, Gustavo Machado das Neves, Gabriela Göethel, Adriano Spillere, Maitê Roxo dos Santos, Fabrício Figueiró, Solange Cristina Garcia, Daiana Silva Ávila, Ana Maria Oliveira Battastini & Vera Lucia Eifler‐Lima. (2023) LaSOM 335, active against bladder cancer cells, interferes with Let‐60 ( h Ras ) and reduces CD 73 expression/activity . Chemical Biology & Drug Design 102:3, pages 536-546.
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Itamar Luís Gonçalves, Liliana Rockenbach, Gabriela Göethel, Elisa Saüer, Luciano Porto Kagami, Gustavo Machado das Neves, Thaís Munhoz, Fabrício Figueiró, Solange Cristina Garcia, Ana Maria Oliveira Batasttini & Vera Lucia Eifler-Lima. (2020) New pharmacological findings linked to biphenyl DHPMs, kinesin Eg5 ligands: anticancer and antioxidant effects. Future Medicinal Chemistry.
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Gabriel O. de Azambuja, Laura Svetaz, Itamar L. Gonçalves, Patricia F. Corbelini, Gilsane L. von Poser, Daniel F. Kawano, Susana Zacchino & Vera L. Eifler-Lima. (2020) In vitro Antifungal Activity of Dihydropyrimidinones/Thiones Against Candida albicans and Cryptococcus neoformans. Current Bioactive Compounds 15:6, pages 648-655.
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Larizza Hellen Santana Matos, Flávia Teixeira Masson, Luiz Alberto Simeoni & Mauricio Homem-de-Mello. (2018) Biological activity of dihydropyrimidinone (DHPM) derivatives: A systematic review. European Journal of Medicinal Chemistry 143, pages 1779-1789.
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Mauricio Cabrera, Stefani de Ovalle, Mariela Bollati-Fogolín, Fabiana Nascimento, Patrícia Corbelini, Fernanda Janarelli, Daniel Kawano, Vera Lucia Eifler-Lima, Mercedes González & Hugo Cerecetto. (2015) New hits as phase II enzymes inducers from a focused library with heteroatom–heteroatom and Michael-acceptor motives. Future Science OA 1:3.
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