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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 4
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Clinical Pharmacokinetics and Metabolism

Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers

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Pages 352-368 | Received 06 Jun 2013, Accepted 30 Jul 2013, Published online: 23 Aug 2013

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C. M. Nijenhuis, J. H. M. Schellens & J. H. Beijnen. (2016) Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review. Drug Metabolism Reviews 48:2, pages 266-280.
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Mark M Awad & Ryan J Sullivan. (2015) Dabrafenib in combination with trametinib for the treatment of metastatic melanoma. Expert Review of Clinical Pharmacology 8:1, pages 25-33.
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Eugene Y. Tan, Marketa Pazdirkova, Amanda J. Taylor, Namrata Singh & Ganesh R. Iyer. (2023) Evaluation of a Low‐Fat Low‐Calorie Meal on the Relative Bioavailability of Trametinib and Dabrafenib: Results From a Randomized, Open‐Label, 2‐Part Study in Healthy Participants. Clinical Pharmacology in Drug Development.
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Pramod C. Nair, Ross A. McKinnon & John O. Miners. (2019) Computational Prediction of the Site(s) of Metabolism and Binding Modes of Protein Kinase Inhibitors Metabolized by CYP3A4. Drug Metabolism and Disposition 47:6, pages 616-631.
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Hannah Yejin Kim, Janna K. Duong, Maria Gonzalez, Georgina V. Long, Alexander M. Menzies, Helen Rizos, Su Yin Lim, Jenny Lee & Alan V. Boddy. (2019) Pharmacokinetic and cytokine profiles of melanoma patients with dabrafenib and trametinib-induced pyrexia. Cancer Chemotherapy and Pharmacology 83:4, pages 693-704.
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Yaakov Cass, Thomas H Connor & Alexander Tabachnik. (2016) Safe handling of oral antineoplastic medications: Focus on targeted therapeutics in the home setting. Journal of Oncology Pharmacy Practice 23:5, pages 350-378.
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Oliver von Richter, Giorgio Massimini, Holger Scheible, Istvan Udvaros & Andreas Johne. (2016) Pimasertib, a selective oral MEK1/2 inhibitor: absolute bioavailability, mass balance, elimination route, and metabolite profile in cancer patients. British Journal of Clinical Pharmacology 82:6, pages 1498-1508.
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Sohita Dhillon. (2016) Dabrafenib plus Trametinib: a Review in Advanced Melanoma with a BRAF V600 Mutation. Targeted Oncology 11:3, pages 417-428.
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Claire Beaumont, Graeme C. Young, Tom Cavalier & Malcolm A. Young. (2014) Human absorption, distribution, metabolism and excretion properties of drug molecules: a plethora of approaches. British Journal of Clinical Pharmacology 78:6, pages 1185-1200.
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Lufang Zhou, Ningning Xu, Yan Sun & Xiaoguang (Margaret) Liu. (2014) Targeted biopharmaceuticals for cancer treatment. Cancer Letters 352:2, pages 145-151.
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Cathrine Leonowens, Carolyn Pendry, John Bauman, Graeme C. Young, May Ho, Frank Henriquez, Lei Fang, Royce A. Morrison, Keith Orford & Daniele Ouellet. (2014) Concomitant oral and intravenous pharmacokinetics of trametinib, a MEK inhibitor, in subjects with solid tumours. British Journal of Clinical Pharmacology 78:3, pages 524-532.
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