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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 4
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Research Article

Metabolism and mass balance of SGLT2 inhibitor tofogliflozin following oral administration to humans

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Pages 369-378 | Received 18 Jul 2013, Accepted 27 Aug 2013, Published online: 27 Sep 2013

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Read on this site (5)

Lydia Wang-Lakshman, Anisha E. Mendonza, Roland Huber, Markus Walles, YanLing He & Venkateswar Jarugula. (2021) Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans. Xenobiotica 51:4, pages 413-426.
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Yukihiro Chino, Masatoshi Hasegawa, Yoshiki Fukasawa, Yoko Mano, Kagumi Bando, Atsunori Miyata, Yasuhiro Nakai, Hiromi Endo & Jun-ichi Yamaguchi. (2017) In vitro evaluation of potential drug interactions mediated by cytochrome P450 and transporters for luseogliflozin, an SGLT2 inhibitor. Xenobiotica 47:4, pages 314-323.
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Kalliopi Pafili, Efstratios Maltezos & Nikolaos Papanas. (2016) Pharmacokinetic and pharmacodynamic drug evaluation of tofogliflozin for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 12:11, pages 1367-1380.
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K. Pafili, E. Maltezos & N. Papanas. (2016) The potential of SGLT2 inhibitors in phase II clinical development for treating type 2 diabetes. Expert Opinion on Investigational Drugs 25:10, pages 1133-1152.
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Mizuki Yamane, Kosuke Kawashima, Koji Yamaguchi, Shunsuke Nagao, Mika Sato, Masayuki Suzuki, Kiyofumi Honda, Hitoshi Hagita, Olaf Kuhlmann, Agnes Poirier, Stephen Fowler, Christoph Funk, Sandrine Simon, Yoshinori Aso, Sachiya Ikeda & Masaki Ishigai. (2015) In vitro profiling of the metabolism and drug–drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP. Xenobiotica 45:3, pages 230-238.
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Articles from other publishers (9)

Magdalena Złotek, Antonina Kurowska, Mariola Herbet & Iwona Piątkowska-Chmiel. (2023) GLP-1 Analogs, SGLT-2, and DPP-4 Inhibitors: A Triad of Hope for Alzheimer’s Disease Therapy. Biomedicines 11:11, pages 3035.
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Anna Gumieniczek & Anna Berecka-Rycerz. (2023) Metabolism and Chemical Degradation of New Antidiabetic Drugs: A Review of Analytical Approaches for Analysis of Glutides and Gliflozins. Biomedicines 11:8, pages 2127.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
Haruki Yamada, Hiromasa Ohira, Fumiaki Ikegami, Koichi Nakamura, Atsushi Takahashi, Kazumichi Abe, Akihiro Inano, Sumire Shimada, Kumiko Miyata, Tomohisa Saito, Yasuhiro Ohba, Kimio Terao & Akihiro Ohnishi. (2020) Effects of Child-Pugh B Cirrhosis on Pharmacokinetics of Tofogliflozin, a New Sodium-Glucose Co-Transporter (SGLT2) Inhibitor. Drug Research 70:09, pages 401-409.
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M. Ruscica, L. Baldessin, D. Boccia, G. Racagni & N. Mitro. (2017) Non-insulin anti-diabetic drugs: An update on pharmacological interactions. Pharmacological Research 115, pages 14-24.
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Shinji Kobuchi, Megumi Matsuno, Etsuko Fukuda, Yukako Ito & Toshiyuki Sakaeda. (2016) Development and validation of an LC–MS/MS method for the determination of tofogliflozin in plasma and its application to a pharmacokinetic study in rats. Journal of Chromatography B 1027, pages 227-233.
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André J. Scheen. (2015) Pharmacokinetics, Pharmacodynamics and Clinical Use of SGLT2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease. Clinical Pharmacokinetics 54:7, pages 691-708.
Crossref
Oleg Demin, Tatiana Yakovleva, Dmitry Kolobkov & Oleg Demin. (2014) Analysis of the efficacy of SGLT2 inhibitors using semi-mechanistic model. Frontiers in Pharmacology 5.
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Raewyn M. Poole & Jennifer E. Prossler. (2014) Tofogliflozin: First Global Approval. Drugs 74:8, pages 939-944.
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