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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 9
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Research Article

Semi-physiological pharmacokinetic–pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats

Shinji KobuchiDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapanCorrespondence[email protected]
,
Yukako ItoDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Taro HayakawaDepartment of Pharmacy, Otsu Municipal Hospital Otsu, ShigaJapan
,
Shota KuwanoDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Akiko BabaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Kota ShinoharaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Asako NishimuraDepartment of Biopharmaceutics, Doshisha Women’s College of Liberal Arts Kyotanabe, KyotoJapan
,
Nobuhito ShibataDepartment of Biopharmaceutics, Doshisha Women’s College of Liberal Arts Kyotanabe, KyotoJapan
&
Kanji TakadaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
 show all
Pages 804-818 | Received 06 Nov 2013, Accepted 28 Feb 2014, Published online: 20 Mar 2014

Citations (7)

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Read on this site (5)

Shinji Kobuchi, Megumi Matsui & Yukako Ito. (2022) Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats. Xenobiotica 52:7, pages 697-706.
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Shinji Kobuchi, Yosuke Katsuyama & Yukako Ito. (2020) Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats. Xenobiotica 50:2, pages 146-153.
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Bianca D. Balmant, Eloisa O. N. Araújo, Denise Yabuki, Amanda B. Novais, Sandra C. Genaro, Cecilia B. Laposy, Paulo F. I. Goiozo, Marcelo G. M. Chacur, Rogério Giuffrida & Luis S. L. S. Reis. (2018) Effects of L-Arginine Supplementation on Leukogram, Inflammatory Bowel Infiltrates and Immunoglobulins with 5-FU Use in Rats. Nutrition and Cancer 70:2, pages 249-256.
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Shinji Kobuchi, Yukako Ito, Yuya Nakano & Toshiyuki Sakaeda. (2016) Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats. Xenobiotica 46:7, pages 597-604.
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Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, Kanji Takada & Toshiyuki Sakaeda. (2015) Semi-physiological pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats. Xenobiotica 45:1, pages 19-28.
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Articles from other publishers (2)

Shinji Kobuchi, Yukako Ito & Toshiyuki Sakaeda. (2016) Population Pharmacokinetic–Pharmacodynamic Modeling of 5-Fluorouracil for Toxicities in Rats. European Journal of Drug Metabolism and Pharmacokinetics 42:4, pages 707-718.
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Shinji Kobuchi, Yukako Ito, Taro Hayakawa, Asako Nishimura, Nobuhito Shibata, Kanji Takada & Toshiyuki Sakaeda. (2014) Pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of 5-fluorouracil for erythropenia in rats. Journal of Pharmacological and Toxicological Methods 70:2, pages 134-144.
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