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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 9
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Research Article

Semi-physiological pharmacokinetic–pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats

Shinji KobuchiDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapanCorrespondence[email protected]
,
Yukako ItoDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Taro HayakawaDepartment of Pharmacy, Otsu Municipal Hospital Otsu, ShigaJapan
,
Shota KuwanoDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Akiko BabaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Kota ShinoharaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
,
Asako NishimuraDepartment of Biopharmaceutics, Doshisha Women’s College of Liberal Arts Kyotanabe, KyotoJapan
,
Nobuhito ShibataDepartment of Biopharmaceutics, Doshisha Women’s College of Liberal Arts Kyotanabe, KyotoJapan
&
Kanji TakadaDepartment of Pharmacokinetics, Kyoto Pharmaceutical University Yamashina-ku, KyotoJapan
 show all
Pages 804-818 | Received 06 Nov 2013, Accepted 28 Feb 2014, Published online: 20 Mar 2014

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