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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 11
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General Xenobiochemistry

Experimental and mathematical analysis of in vitro Pitavastatin hepatic uptake across species

Thomas R. B. GrandjeanSchool of Engineering, University of Warwick CoventryUK
,
Mike J. ChappellSchool of Engineering, University of Warwick CoventryUKCorrespondence[email protected]
,
Alex M. LenchR&D, Innovative Medicines, AstraZeneca MacclesfieldUK
,
James W. T. YatesR&D, Innovative Medicines, AstraZeneca MacclesfieldUK
&
Charles J. O’DonnellR&D, Innovative Medicines, AstraZeneca MacclesfieldUK
Pages 961-974 | Received 04 Mar 2014, Accepted 09 May 2014, Published online: 16 Jul 2014

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Simon J. Carter, Alex S. Ferecskó, Lloyd King, Karelle Ménochet, Ted Parton & Michael J. Chappell. (2020) A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method. Xenobiotica 50:4, pages 415-426.
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Articles from other publishers (2)

Simon J. Carter, Bhavik Chouhan, Pradeep Sharma & Michael J. Chappell. (2020) Prediction of Clinical Transporter‐Mediated Drug–Drug Interactions via Comeasurement of Pitavastatin and Eltrombopag in Human Hepatocyte Models. CPT: Pharmacometrics & Systems Pharmacology 9:4, pages 211-221.
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Paresh P. Chothe, Shu-Pei Wu, Zhengqi Ye & Niresh Hariparsad. (2018) Assessment of Transporter-Mediated and Passive Hepatic Uptake Clearance Using Rifamycin-SV as a Pan-Inhibitor of Active Uptake. Molecular Pharmaceutics 15:10, pages 4677-4688.
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