Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 1
540
Views
53
CrossRef citations to date
0
Altmetric
Research Article

A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine

, , &
Pages 79-87 | Received 01 May 2014, Accepted 05 Jul 2014, Published online: 18 Jul 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Parvaneh Naserzadeh, Farzaneh Jokar, Farzaneh Vafaei, Enayatollah Seydi & Jalal Pourahmad. (2018) Toxicity of new synthetic amphetamine drug mephedrone On Rat Heart mitochondria: a warning for its abuse. Xenobiotica 48:12, pages 1278-1284.
Read now
Aziz Eftekhari, Elham Ahmadian, Vahid Panahi-Azar, Hedayat Hosseini, Mahnaz Tabibiazar & Solmaz Maleki Dizaj. (2018) Hepatoprotective and free radical scavenging actions of quercetin nanoparticles on aflatoxin B1-induced liver damage: in vitro/in vivo studies. Artificial Cells, Nanomedicine, and Biotechnology 46:2, pages 411-420.
Read now
Liyun Cao, Wuqiang Zhu, Elizabeth A. Wagar & Qing H. Meng. (2017) Biomarkers for monitoring chemotherapy-induced cardiotoxicity. Critical Reviews in Clinical Laboratory Sciences 54:2, pages 87-101.
Read now
Aziz Eftekhari, Yadollah Azarmi, Alireza Parvizpur & Mohammad Ali Eghbal. (2016) Involvement of oxidative stress and mitochondrial/lysosomal cross-talk in olanzapine cytotoxicity in freshly isolated rat hepatocytes. Xenobiotica 46:4, pages 369-378.
Read now
Ahmad Salimi, Sadaf Eybagi, Enayatollah Seydi, Parvaneh Naserzadeh, Negar Panahi Kazerouni & Jalal Pourahmad. (2016) Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. Xenobiotica 46:1, pages 82-93.
Read now
Mahmoud Hashemzaei, Jalal Pourahmad, Fahimeh Safaeinejad, Kaveh Tabrizian, Fahimeh Akbari, Gholamreza Bagheri, Mir-Jamal Hosseini & Jafar Shahraki. (2015) Antimony induces oxidative stress and cell death in normal hepatocytes. Toxicological & Environmental Chemistry 97:2, pages 256-265.
Read now

Articles from other publishers (47)

Chenchen Meng, Xiaoming Wang, Lu Fan, Yajie Fan, Zhipeng Yan, Yunjiao Wang, Yanyang Li, Junping Zhang & Shichao Lv. (2024) A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology. Biomedicine & Pharmacotherapy 170, pages 115588.
Crossref
Rajesh Kumar, Charanjit Kaur, Kawalpreet Kaur, Navneet Khurana & Gurvinder Singh. (2023) Prodrugs: Harnessing chemical modifications for improved therapeutics. Journal of Drug Delivery Science and Technology 90, pages 105103.
Crossref
Carmine Rocca, Teresa Soda, Ernestina Marianna De Francesco, Marco Fiorillo, Francesco Moccia, Giuseppe Viglietto, Tommaso Angelone & Nicola Amodio. (2023) Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer. Journal of Translational Medicine 21:1.
Crossref
Md. Shimul Bhuia, Raihan Chowdhury, Fatema Akter Sonia, Hossam Kamli, Ahmad Shaikh, Heba A. S. El‐Nashar, Mohamed El‐Shazly & Muhammad Torequl Islam. (2023) Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches. Chemistry & Biodiversity.
Crossref
Jing Xia, Qian long Dai, Siyue He, Hui-jie Jia, Xian-Guo Liu, Hui Hua, Min Zhou & Xiaobo Wang. (2023) Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity. Discover Oncology 14:1.
Crossref
Nageswaran Sivalingam, Thennavan Ulaganathan, Ganshyam Jayakumar, Siddarth Venkatt, Aadhavan Balakumar & Sruthi Sritharan. 2023. Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine. Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine 61 115 .
Paweł Uruski, Julia Matuszewska, Aleksandra Leśniewska, Daniel Rychlewski, Arkadiusz Niklas, Justyna Mikuła-Pietrasik, Andrzej Tykarski & Krzysztof Książek. (2023) An integrative review of nonobvious puzzles of cellular and molecular cardiooncology. Cellular & Molecular Biology Letters 28:1.
Crossref
Prasad Kisan Tambe, A. Jesil Mathew & Sanjay Bharati. (2023) Cardioprotective potential of mitochondria-targeted antioxidant, mito-TEMPO, in 5-fluorouracil-induced cardiotoxicity. Cancer Chemotherapy and Pharmacology 91:5, pages 389-400.
Crossref
Yang Gui, Ademola C. Famurewa & Opeyemi Joshua Olatunji. (2023) Naringin ameliorates 5-fluorouracil induced cardiotoxicity: An insight into its modulatory impact on oxidative stress, inflammatory and apoptotic parameters. Tissue and Cell 81, pages 102035.
Crossref
Kiran Das, Madhuri Basak, Tarun Mahata, Manish Kumar, Dinesh Kumar, Sayan Biswas, Suvro Chatterjee, Mahammed Moniruzzaman, Nimai Chandra Saha, Kausik Mondal, Pranesh Kumar, Priyadip Das, Adele Stewart & Biswanath Maity. (2022) RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis. Redox Biology 57, pages 102487.
Crossref
Maha S. Lokman, Hussam A. Althagafi, Fahad Alharthi, Ola A. Habotta, Arwa A. Hassan, Mohamed A. Elhefny, Hassan Al Sberi, Abdulrahman Theyab, Ahmad Hasan Mufti, Alaa Alhazmi, Yousef M. Hawsawi, Asmaa F. Khafaga, Mahmoud S. Gewaily, Khalaf F. Alsharif, Ashraf Albrakati & Rami B. Kassab. (2022) Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities. Environmental Science and Pollution Research 30:7, pages 17657-17669.
Crossref
Jean C. Bikomeye, Janée D. Terwoord, Janine H. Santos & Andreas M. Beyer. (2022) Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress. American Journal of Physiology-Heart and Circulatory Physiology 323:4, pages H702-H720.
Crossref
Marwa M. M. Refaie, Sayed Shehata, Asmaa M. A. Bayoumi, Nashwa Fathy Gamal El-Tahawy & Walaa Yehia Abdelzaher. (2021) The IL-6/STAT Signaling Pathway and PPARα Are Involved in Mediating the Dose-Dependent Cardioprotective Effects of Fenofibrate in 5-Fluorouracil-Induced Cardiotoxicity. Cardiovascular Drugs and Therapy 36:5, pages 817-827.
Crossref
Chenchen Meng, Lu Fan, Xiaoming Wang, Yunjiao Wang, Yanyang Li, Shuchao Pang, Shichao Lv & Junping Zhang. (2022) Preparation and Evaluation of Animal Models of Cardiotoxicity in Antineoplastic Therapy. Oxidative Medicine and Cellular Longevity 2022, pages 1-16.
Crossref
Soheila Safarpour, Samaneh Safarpour, Ali A. Moghadamnia, Sohrab Kazemi, Anahita Ebrahimpour, Fatemeh Shirafkan, Razieh Mansoori & Ravieh Golchoobian. (2022) Cardioprotective effect of silymarin nanoemulsion on 5‐fluorouracil‐induced cardiotoxicity in rats. Archiv der Pharmazie 355:7.
Crossref
Despoina Pantazi & Alexandros D. Tselepis. (2022) Cardiovascular toxic effects of antitumor agents: Pathogenetic mechanisms. Thrombosis Research 213, pages S95-S102.
Crossref
Sai Zhang, Shunli Fan, Zhenglu Wang, Wen Hou, Tao Liu, Sei Yoshida, Shuang Yang, Hong Zheng & Zhongyang Shen. (2022) Capecitabine Regulates HSP90AB1 Expression and Induces Apoptosis via Akt/SMARCC1/AP-1/ROS Axis in T Cells. Oxidative Medicine and Cellular Longevity 2022, pages 1-15.
Crossref
Soheila Safarpour, Marzieh Pirzadeh, Anahita Ebrahimpour, Fatemeh Shirafkan, Fateme Madani, Mohammad Hosseini, Ali Akbar Moghadamnia & Sohrab Kazemi. (2022) Protective Effect of Kaempferol and Its Nanoparticles on 5-Fluorouracil-Induced Cardiotoxicity in Rats. BioMed Research International 2022, pages 1-13.
Crossref
Farah Cadour, Franck Thuny & Joevin Sourdon. (2022) New Insights in Early Detection of Anticancer Drug-Related Cardiotoxicity Using Perfusion and Metabolic Imaging. Frontiers in Cardiovascular Medicine 9.
Crossref
Ahmad Salimi, Ali Alavehzadeh, Maral Ramezani & Jalal Pourahmad. (2022) Differences in sensitivity of human lymphocytes and fish lymphocytes to polyvinyl chloride microplastic toxicity. Toxicology and Industrial Health 38:2, pages 100-111.
Crossref
Soheila Safarpour, Samaneh Safarpour, Marzieh Pirzadeh, Ali Akbar Moghadamnia, Anahita Ebrahimpour, Fatemeh Shirafkan, Razieh Mansoori, Sohrab Kazemi & Mohammad Hosseini. (2022) Colchicine Ameliorates 5-Fluorouracil-Induced Cardiotoxicity in Rats. Oxidative Medicine and Cellular Longevity 2022, pages 1-13.
Crossref
Cliff J. Luke, Stephanie Markovina, Misty Good, Ira E. Wight, Brian J. Thomas, John M. Linneman, Wyatt E. Lanik, Olga Koroleva, Maggie R. Coffman, Mark T. Miedel, Qingqing Gong, Arlise Andress, Marlene Campos Guerrero, Songyan Wang, LiYun Chen, Wandy L. Beatty, Kelsey N. Hausmann, Frances V. White, James A. J. Fitzpatrick, Anthony Orvedahl, Stephen C. Pak & Gary A. Silverman. (2022) Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Communications Biology 5:1.
Crossref
Yuanyang Li, Yufan Zhang, Xiangzhong Zhou, Xianghong Lei, Xinhang Li & Liping Wei. (2021) Dynamic observation of 5‑fluorouracil‑induced myocardial injury and mitochondrial autophagy in aging rats. Experimental and Therapeutic Medicine 22:6.
Crossref
Adriana Albini, Marco M. G. Festa, Nadja Ring, Denisa Baci, Michael Rehman, Giovanna Finzi, Fausto Sessa, Serena Zacchigna, Antonino Bruno & Douglas M. Noonan. (2021) A Polyphenol-Rich Extract of Olive Mill Wastewater Enhances Cancer Chemotherapy Effects, While Mitigating Cardiac Toxicity. Frontiers in Pharmacology 12.
Crossref
Wendy Keung & Yiu-Fai Cheung. (2021) Human Pluripotent Stem Cells for Modeling of Anticancer Therapy-Induced Cardiotoxicity and Cardioprotective Drug Discovery. Frontiers in Pharmacology 12.
Crossref
Erin N McAndrew, Davinder S Jassal, Benjamin A Goldenberg & Christina A Kim. (2021) Capecitabine-mediated heart failure in colorectal cancer: a case series. European Heart Journal - Case Reports 5:3.
Crossref
Andrada Larisa Deac, Claudia Cristina Burz, Ioana Corina Bocsan & Anca Dana Buzoianu. (2020) Fluoropyrimidine-induced cardiotoxicity. World Journal of Clinical Oncology 11:12, pages 1008-1017.
Crossref
Semin GEDİKLİ & Elif ERBAŞ. (2020) Protective Effects of Naringin on Lung Toxicity Induced by 5-Fluorouracil in Rats. Kocatepe Veterinary Journal.
Crossref
Radwa Nasser Muhammad, Nada Sallam & Hanan Salah El-Abhar. (2020) Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin. Scientific Reports 10:1.
Crossref
Joerg Herrmann. (2020) Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia. Nature Reviews Cardiology 17:8, pages 474-502.
Crossref
Wanjun Ma, Shanshan Wei, Bikui Zhang & Wenqun Li. (2020) Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity. Frontiers in Cell and Developmental Biology 8.
Crossref
Rafey A. Feroze, Jeff Leya, Todd Herron & Salim S. Hayek. (2020) Clinical and Research Tools for the Study of Cardiovascular Effects of Cancer Therapy. Journal of Cardiovascular Translational Research 13:3, pages 417-430.
Crossref
Mahmoud Hashemzaei, Kaveh Tabrizian, Zeinab Alizadeh, Sedigheh Pasandideh, Ramin Rezaee, Charalampos Mamoulakis, Aristidis Tsatsakis, Zoi Skaperda, Demetrios Kouretas & Jafar Shahraki. (2020) Resveratrol, curcumin and gallic acid attenuate glyoxal-induced damage to rat renal cells. Toxicology Reports 7, pages 1571-1577.
Crossref
Anju Nohria. (2019) The clinical conundrum of managing 5‐fluorouracil–induced vasospasm in colorectal carcinoma. Cancer 125:24, pages 4346-4349.
Crossref
Zhilei Wang, Chengxin Gu, Xinrui Wang, Yating Lang, Yanqin Wu, Xiaoqin Wu, Xifei Zhu, Kunyuan Wang & Hui Yang. (2019) Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma. Medical Oncology 36:12.
Crossref
Benson Otarigho. (2019) Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs. F1000Research 8, pages 651.
Crossref
Sebastian Brachtendorf, Ruth Anna Wanger, Kerstin Birod, Dominique Thomas, Sandra Trautmann, Marthe-Susanna Wegner, Dominik C. Fuhrmann, Bernhard Brüne, Gerd Geisslinger & Sabine Grösch. (2018) Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1863:10, pages 1214-1227.
Crossref
Ilaria Depetris, Donatella Marino, Alessandro Bonzano, Celeste Cagnazzo, Roberto Filippi, Massimo Aglietta & Francesco Leone. (2018) Fluoropyrimidine-induced cardiotoxicity. Critical Reviews in Oncology/Hematology 124, pages 1-10.
Crossref
Aziz Eftekhari, Elham Ahmadian, Aida Azami, Mohammad Johari-Ahar & Mohammad Ali Eghbal. (2018) Protective effects of coenzyme Q10 nanoparticles on dichlorvos-induced hepatotoxicity and mitochondrial/lysosomal injury. Environmental Toxicology 33:2, pages 167-177.
Crossref
Yumeng Wei, Panjing Yang, Shousong Cao & Ling Zhao. (2017) The combination of curcumin and 5-fluorouracil in cancer therapy. Archives of Pharmacal Research 41:1, pages 1-13.
Crossref
Xinqiang Han, Yun Zhou & Wendi Liu. (2017) Precision cardio-oncology: understanding the cardiotoxicity of cancer therapy. npj Precision Oncology 1:1.
Crossref
Ronald J. Krone, Preet Paul Singh & Chiara Melloni. 2017. Cardio-Oncology. Cardio-Oncology 175 214 .
Barbara Bassani, Antonino Bruno, Nicoletta Macrì, Paola Corradino, Douglas M. Noonan & Adriana Albini. 2017. Manual of Cardio-oncology. Manual of Cardio-oncology 107 122 .
Elham Ahmadian, Hossein Babaei, Alireza Mohajjel Nayebi, Aziz Eftekhari & Mohammad Ali Eghbal. (2016) Venlafaxine-Induced Cytotoxicity Towards Isolated Rat Hepatocytes Involves Oxidative Stress and Mitochondrial/Lysosomal Dysfunction. Advanced Pharmaceutical Bulletin 6:4, pages 521-530.
Crossref
Luisa De Gennaro, Natale Daniele Brunetti, Manuela Resta, David Rutigliano, Luigi Tarantini & Pasquale Caldarola. (2016) Cardiac arrest and ventricular fibrillation in a young man treated with capecitabine: Case report and literature review. International Journal of Cardiology 220, pages 280-283.
Crossref
Seyyedeh S Saneeymehri, Kelly R Markey & Amit Mahipal. (2015) Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review. Journal of Oncology Pharmacy Practice 22:3, pages 552-555.
Crossref
Clelia Madeddu, Martino Deidda, Alessandra Piras, Christian Cadeddu, Laura Demurtas, Marco Puzzoni, Giovanna Piscopo, Mario Scartozzi & Giuseppe Mercuro. (2016) Pathophysiology of cardiotoxicity induced by nonanthracycline chemotherapy. Journal of Cardiovascular Medicine 17, pages e12-e18.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.