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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 3
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Research Article

Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects

Jian GuoDMPK of Infection Innovative Medicine, AstraZeneca Pharmaceuticals, Waltham, MA, USA and Correspondence[email protected] [email protected]
,
Diansong ZhouEarly Clinical Development, AstraZeneca Pharmaceuticals, Wilmington, DE, USA
,
Scott W. GrimmDMPK of Infection Innovative Medicine, AstraZeneca Pharmaceuticals, Waltham, MA, USA and
&
Khanh H. BuiEarly Clinical Development, AstraZeneca Pharmaceuticals, Wilmington, DE, USA
Pages 244-255 | Received 20 Aug 2014, Accepted 12 Sep 2014, Published online: 26 Sep 2014

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Gopalkumar Rakesh, Chi-Un Pae & Prakash S. Masand. (2017) Beyond serotonin: newer antidepressants in the future. Expert Review of Neurotherapeutics 17:8, pages 777-790.
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Sara Safari, Ahmad Amiri & Alireza Badiei. (2023) Selective detection of aspartic acid in human serum by a fluorescent probe based on CuInS2@ZnS quantum dots. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 291, pages 122294.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
Robert Becker, Natalia Gass, Lothar Kußmaul, Bernhard Schmid, Stefan Scheuerer, David Schnell, Cornelia Dorner-Ciossek, Wolfgang Weber-Fahr & Alexander Sartorius. (2019) NMDA receptor antagonists traxoprodil and lanicemine improve hippocampal-prefrontal coupling and reward-related networks in rats. Psychopharmacology 236:12, pages 3451-3463.
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F. Agbo, K. H. Bui & D. Zhou. (2017) Population pharmacokinetic analysis of lanicemine (AZD6765), an NMDA channel blocker, in healthy subjects and patients with major depressive disorder. Journal of Clinical Pharmacy and Therapeutics 42:5, pages 539-546.
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J. Iegre, M. A. Hayes, R. A. Thompson, L. Weidolf & E. M. Isin. (2016) Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data. Drug Metabolism and Disposition 44:5, pages 732-740.
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Khanh H. Bui, Diansong Zhou, Felix Agbo & Jian Guo. (2015) Effect of multiple intravenous doses of lanicemine (AZD6765) on the pharmacokinetics of midazolam in healthy subjects. The Journal of Clinical Pharmacology 55:9, pages 1024-1030.
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