Xenobiotica, Volume 45, Issue 3 (2015)

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Xenobiotica, Volume 45, Issue 3 (2015)

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Research Article

Article
Metabolite profiling of anhuienoside C by rat intestinal bacteria using the LC–MS metabolomic approach
Huinan Zhao, Hui Liu, Zhiguo Ma, Ying Wang, Yao-lan Li, Wen-Cai Ye & Baojian Wu
Pages: 189-196
Published online: 15 Sep 2014
AbstractforMetabolite profiling of anhuienoside C by rat intestinal bacteria using the LC–MS metabolomic approach | Full Text | References | PDF (791.2 KB) | Supplemental
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Article
Regulation profile of phosphatidylcholines (PCs) and lysophosphatidylcholines (LPCs) components towards UDP-glucuronosyltransferases (UGTs) isoforms
Xin Gao, Hengyan Qu, Chun-Zhi Ai, Yun-Feng Cao, Ting Huang, Jian-Xing Chen, Jia Zeng, Xiao-Yu Sun, Mo Hong, Frank J. Gonzalez, Zeyuan Liu & Zhong-Ze Fang
Pages: 197-206
Published online: 26 Sep 2014
AbstractforRegulation profile of phosphatidylcholines (PCs) and lysophosphatidylcholines (LPCs) components towards UDP-glucuronosyltransferases (UGTs) isoforms | Full Text | References | PDF (937.2 KB) | Supplemental
  • 209 Views
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Article
Protein binding of fentanyl and its metabolite nor-fentanyl in human plasma, albumin and α-1 acid glycoprotein
Sudeep Raj Bista, Alison Haywood, Janet Hardy, Michael Lobb, Angela Tapuni & Ross Norris
Pages: 207-212
Published online: 14 Oct 2014
AbstractforProtein binding of fentanyl and its metabolite nor-fentanyl in human plasma, albumin and α-1 acid glycoprotein | Full Text | References | PDF (132.8 KB)
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Article
Time-dependent inhibition of CYP3A4 by gallic acid in human liver microsomes and recombinant systems
Qiang-Hong Pu, Liang Shi & Chao Yu
Pages: 213-217
Published online: 17 Oct 2014
AbstractforTime-dependent inhibition of CYP3A4 by gallic acid in human liver microsomes and recombinant systems | Full Text | References | PDF (347.4 KB)
  • 246 Views
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Article
Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway
Charles Awortwe, Vamshi K. Manda, Cristina Avonto, Shabana I. Khan, Ikhlas A. Khan, Larry A. Walker, Patrick J. Bouic & Bernd Rosenkranz
Pages: 218-229
Published online: 07 Nov 2014
AbstractforEchinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway | Full Text | References | PDF (658.3 KB)
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Article
In vitro profiling of the metabolism and drug–drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP
Mizuki Yamane, Kosuke Kawashima, Koji Yamaguchi, Shunsuke Nagao, Mika Sato, Masayuki Suzuki, Kiyofumi Honda, Hitoshi Hagita, Olaf Kuhlmann, Agnes Poirier, Stephen Fowler, Christoph Funk, Sandrine Simon, Yoshinori Aso, Sachiya Ikeda & Masaki Ishigai
Pages: 230-238
Published online: 28 Oct 2014
AbstractforIn vitro profiling of the metabolism and drug–drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP | Full Text | References | PDF (268.4 KB) | Supplemental
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Free Access
Article
Pharmacokinetics of peramivir after single intravenous doses in healthy Chinese subjects
Dan Zhang, Aihua Du, Lina Zhang, Jingyi Ma, Lingjie Meng, Ming Deng, Juan Xu & Huichen Liu
Pages: 239-243
Published online: 18 Sep 2014
AbstractforPharmacokinetics of peramivir after single intravenous doses in healthy Chinese subjects | Full Text | References | PDF (192.1 KB)
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Article
Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects
Jian Guo, Diansong Zhou, Scott W. Grimm & Khanh H. Bui
Pages: 244-255
Published online: 26 Sep 2014
AbstractforPharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects | Full Text | References | PDF (1.2 MB)
  • 286 Views
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Article
Effect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers
Doo-Yeoun Cho, Soo Hyeon Bae, Joeng Kee Lee, Jung Bae Park, Yang-Weon Kim, Sukhyang Lee, Euichaul Oh, Bom-Taeck Kim & Soo Kyung Bae
Pages: 256-263
Published online: 30 Sep 2014
AbstractforEffect of the potent CYP2D6 inhibitor sarpogrelate on the pharmacokinetics and pharmacodynamics of metoprolol in healthy male Korean volunteers | Full Text | References | PDF (512.3 KB)
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Article
Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin after intravenous and intramuscular administration in beagle dogs
Sileshi Yohannes, Elias Gebru Awji, Seung-Jin Lee & Seung-Chun Park
Pages: 264-269
Published online: 03 Dec 2014
AbstractforPharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin after intravenous and intramuscular administration in beagle dogs | Full Text | References | PDF (263.9 KB)
  • 236 Views
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Article
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
Hong Yu, Nigel Barrass, Sonya Gales, Eva Lenz, Tony Parry, Helen Powell, Dale Thurman, Michael Hutchison, Ian D. Wilson, Luke Bi, Junwen Qiao, Qiuping Qin & Jin Ren
Pages: 270-277
Published online: 22 Oct 2014
AbstractforMetabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey | Full Text | References | PDF (265.2 KB)
  • 387 Views
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